SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2v0s LR1
(Homo
sapiens) 		5 / 12 ILE A 180
GLY A 207
LEU A 112
ILE A 125
SER A 151
 None
 1.11A 1zq9A-2v0sA:
undetectable		 1zq9A-2v0sA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2v0s LR1
(Homo
sapiens) 		5 / 10 ALA A 116
ILE A 125
GLY A 144
HIS A 228
LYS A 201
 None
None
None
GOL  A1240 (-4.1A)
None
 1.04A 2b17A-2v0sA:
undetectable		 2b17A-2v0sA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 2v0s LR1
(Homo
sapiens) 		5 / 12 LEU A  77
LEU A  54
LEU A  18
ILE A  15
ALA A  28
 None
 1.21A 2bxpA-2v0sA:
undetectable		 2bxpA-2v0sA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2v0s LR1
(Homo
sapiens) 		3 / 3 ARG A 182
ASN A 147
THR A 192
 None
GOL  A1240 (-2.9A)
None
 0.80A 2q63A-2v0sA:
undetectable		 2q63A-2v0sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2v0s LR1
(Homo
sapiens) 		5 / 9 LEU A 129
LEU A 172
VAL A 206
PHE A 146
THR A 140
 None
 1.26A 3freX-2v0sA:
undetectable		 3freX-2v0sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2v0s LR1
(Homo
sapiens) 		3 / 3 LYS A 201
THR A 192
ILE A 221
 None
 0.91A 4e0fB-2v0sA:
undetectable		 4e0fB-2v0sA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v0s LR1
(Homo
sapiens) 		4 / 8 ILE A  98
ARG A  91
PRO A  36
VAL A  78
 None
 1.26A 4f4dB-2v0sA:
undetectable		 4f4dB-2v0sA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2v0s LR1
(Homo
sapiens) 		4 / 7 ASP A 145
GLN A  42
ASN A 147
ILE A 125
 GOL  A1240 (-2.7A)
None
GOL  A1240 (-2.9A)
None
 1.11A 4ii8A-2v0sA:
undetectable		 4ii8A-2v0sA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2v0s LR1
(Homo
sapiens) 		4 / 7 ASP A 145
GLN A  42
THR A  12
ILE A 231
 GOL  A1240 (-2.7A)
None
None
None
 0.92A 4pcuA-2v0sA:
undetectable		 4pcuA-2v0sA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2v0s LR1
(Homo
sapiens) 		4 / 7 PHE A 146
ASP A 145
THR A  12
ILE A 231
 None
GOL  A1240 (-2.7A)
None
None
 0.96A 4pcuA-2v0sA:
undetectable		 4pcuA-2v0sA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2v0s LR1
(Homo
sapiens) 		5 / 11 LEU A 112
ASP A 145
GLN A  42
THR A  12
ILE A 231
 None
GOL  A1240 (-2.7A)
None
None
None
 1.19A 4uuuA-2v0sA:
undetectable
4uuuB-2v0sA:
undetectable		 4uuuA-2v0sA:
20.36
4uuuB-2v0sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2v0s LR1
(Homo
sapiens) 		5 / 11 LEU A 112
ASP A 145
GLN A  42
THR A  12
ILE A 231
 None
GOL  A1240 (-2.7A)
None
None
None
 1.21A 4uuuB-2v0sA:
undetectable		 4uuuB-2v0sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2v0s LR1
(Homo
sapiens) 		4 / 9 ILE A  10
VAL A  78
THR A  82
ILE A 104
 None
 0.75A 5lg3I-2v0sA:
undetectable		 5lg3I-2v0sA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2v0s LR1
(Homo
sapiens) 		5 / 12 ILE A  15
ILE A 111
ILE A  62
VAL A 100
ILE A  98
 None
 0.97A 5mueA-2v0sA:
undetectable		 5mueA-2v0sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2v0s LR1
(Homo
sapiens) 		5 / 12 ILE A  76
LEU A 141
THR A  82
ILE A 104
THR A  12
 None
 1.18A 5z6fA-2v0sA:
undetectable		 5z6fA-2v0sA:
21.49