SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U1J_A_C2FA773_0 (5-METHYLTETRAHYDROPT EROYLTRIGLUTAMATE--H OMOCYSTEINE METHYLTRANSFERASE)	2v14	KINESIN-LIKE MOTOR PROTEIN C20ORF23 (Homo sapiens)	4 / 8	ARG A1261 ARG A1269 VAL A1206 TRP A1215	None	1.35A	1u1jA-2v14A: undetectable	1u1jA-2v14A: 10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_B_CHDB503_0 (FERROCHELATASE, MITOCHONDRIAL)	2v14	KINESIN-LIKE MOTOR PROTEIN C20ORF23 (Homo sapiens)	4 / 8	SER A1293 LYS A1287 VAL A1288 GLY A1289	None	0.96A	4klrB-2v14A: undetectable	4klrB-2v14A: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNA_A_ACTA307_0 (THIOREDOXIN REDUCTASE)	2v14	KINESIN-LIKE MOTOR PROTEIN C20ORF23 (Homo sapiens)	3 / 3	ARG A1190 LYS A1207 TYR A1311	None	1.24A	6gnaA-2v14A: undetectable	6gnaA-2v14A: 17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNB_A_ACTA307_0 (THIOREDOXIN REDUCTASE)	2v14	KINESIN-LIKE MOTOR PROTEIN C20ORF23 (Homo sapiens)	3 / 3	ARG A1190 LYS A1207 TYR A1311	None	1.24A	6gnbA-2v14A: undetectable	6gnbA-2v14A: 17.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1U1J_A_C2FA773_0","5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE","2v14","KINESIN-LIKE MOTOR PROTEIN C20ORF23","Homo sapiens",4,"ARG A1261;ARG A1269;VAL A1206;TRP A1215","None","1.35A","1u1jA-2v14A:undetectable","1u1jA-2v14A:10.53"],["4KLR_B_CHDB503_0","FERROCHELATASE, MITOCHONDRIAL","2v14","KINESIN-LIKE MOTOR PROTEIN C20ORF23","Homo sapiens",4,"SER A1293;LYS A1287;VAL A1288;GLY A1289","None","0.96A","4klrB-2v14A:undetectable","4klrB-2v14A:16.89"],["6GNA_A_ACTA307_0","THIOREDOXIN REDUCTASE","2v14","KINESIN-LIKE MOTOR PROTEIN C20ORF23","Homo sapiens",3,"ARG A1190;LYS A1207;TYR A1311","None","1.24A","6gnaA-2v14A:undetectable","6gnaA-2v14A:17.44"],["6GNB_A_ACTA307_0","THIOREDOXIN REDUCTASE","2v14","KINESIN-LIKE MOTOR PROTEIN C20ORF23","Homo sapiens",3,"ARG A1190;LYS A1207;TYR A1311","None","1.24A","6gnbA-2v14A:undetectable","6gnbA-2v14A:17.44"]]