SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2v1l HYPOTHETICAL PROTEIN
(Vibrio
cholerae) 		5 / 12 LEU A  21
HIS A  28
ILE A 142
PHE A  45
ILE A  62
 None
 1.41A 1ot7B-2v1lA:
undetectable		 1ot7B-2v1lA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2v1l HYPOTHETICAL PROTEIN
(Vibrio
cholerae) 		3 / 3 ILE A  62
ASP A  79
PHE A  80
 None
 0.50A 1uwjB-2v1lA:
undetectable		 1uwjB-2v1lA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2v1l HYPOTHETICAL PROTEIN
(Vibrio
cholerae) 		4 / 5 ILE A  62
PHE A  98
PHE A  96
ILE A  13
 None
 1.15A 2hjhA-2v1lA:
undetectable		 2hjhA-2v1lA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2v1l HYPOTHETICAL PROTEIN
(Vibrio
cholerae) 		5 / 12 PHE A  45
VAL A  60
ALA A  19
ALA A  22
LEU A  64
 None
 1.31A 2x2nC-2v1lA:
undetectable		 2x2nC-2v1lA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2v1l HYPOTHETICAL PROTEIN
(Vibrio
cholerae) 		4 / 6 TRP A  72
ILE A  74
THR A   9
VAL A  42
 None
 1.08A 4iaqA-2v1lA:
undetectable		 4iaqA-2v1lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2v1l HYPOTHETICAL PROTEIN
(Vibrio
cholerae) 		5 / 12 LEU A  64
THR A   9
HIS A  18
ILE A  62
PHE A  17
 None
 1.14A 4rp8C-2v1lA:
undetectable		 4rp8C-2v1lA:
16.45