SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	2v1o	CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE (Mus musculus)	5 / 11	LEU A 112 LYS A 111 PHE A 70 LEU A 71 PRO A 73	None	1.32A	1klmA-2v1oA: undetectable	1klmA-2v1oA: 13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_A_SAMA300_0 (HEMK PROTEIN)	2v1o	CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE (Mus musculus)	5 / 12	PRO A 73 THR A 113 ILE A 17 GLY A 77 ALA A 23	None	1.13A	1nv8A-2v1oA: undetectable	1nv8A-2v1oA: 19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AX8_A_SAMA1474_0 (WBDD)	2v1o	CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE (Mus musculus)	5 / 12	GLY A 42 ILE A 44 ILE A 45 VAL A 96 ILE A 86	None	0.92A	4ax8A-2v1oA: undetectable	4ax8A-2v1oA: 14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZV_A_SAMA1474_0 (WBDD)	2v1o	CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE (Mus musculus)	5 / 12	GLY A 42 ILE A 44 ILE A 45 VAL A 96 ILE A 86	None	0.90A	4azvA-2v1oA: undetectable	4azvA-2v1oA: 14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M0I_B_ACTB303_0 (SWI5-DEPENDENT HO EXPRESSION PROTEIN 2)	2v1o	CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE (Mus musculus)	4 / 5	VAL A 65 THR A 68 ASN A 114 LEU A 35	None	1.23A	5m0iB-2v1oA: undetectable	5m0iB-2v1oA: 20.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KLM_A_SPPA999_1","HIV-1 REVERSE TRANSCRIPTASE","2v1o","CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE","Mus musculus",5,"LEU A 112;LYS A 111;PHE A  70;LEU A  71;PRO A  73","None","1.32A","1klmA-2v1oA:undetectable","1klmA-2v1oA:13.24"],["1NV8_A_SAMA300_0","HEMK PROTEIN","2v1o","CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE","Mus musculus",5,"PRO A  73;THR A 113;ILE A  17;GLY A  77;ALA A  23","None","1.13A","1nv8A-2v1oA:undetectable","1nv8A-2v1oA:19.59"],["4AX8_A_SAMA1474_0","WBDD","2v1o","CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE","Mus musculus",5,"GLY A  42;ILE A  44;ILE A  45;VAL A  96;ILE A  86","None","0.92A","4ax8A-2v1oA:undetectable","4ax8A-2v1oA:14.00"],["4AZV_A_SAMA1474_0","WBDD","2v1o","CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE","Mus musculus",5,"GLY A  42;ILE A  44;ILE A  45;VAL A  96;ILE A  86","None","0.90A","4azvA-2v1oA:undetectable","4azvA-2v1oA:14.00"],["5M0I_B_ACTB303_0","SWI5-DEPENDENT HO EXPRESSION PROTEIN 2","2v1o","CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE","Mus musculus",4,"VAL A  65;THR A  68;ASN A 114;LEU A  35","None","1.23A","5m0iB-2v1oA:undetectable","5m0iB-2v1oA:20.50"]]