SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 6 LEU A 344
GLY A 324
LYS A 331
TYR A 327
 None
 1.27A 1gtiC-2v1uA:
undetectable		 1gtiC-2v1uA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 5 LEU A 344
GLY A 324
LYS A 331
TYR A 327
 None
 1.28A 1gtiF-2v1uA:
undetectable		 1gtiF-2v1uA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 HIS A 303
THR A 334
TYR A 330
TYR A 327
 None
 1.01A 1qzrA-2v1uA:
undetectable		 1qzrA-2v1uA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 HIS A 303
THR A 334
TYR A 330
TYR A 327
 None
 1.01A 1qzrB-2v1uA:
undetectable		 1qzrB-2v1uA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 LEU A 314
LEU A 308
VAL A 307
ILE A 350
VAL A 376
 None
 1.01A 1s19A-2v1uA:
undetectable		 1s19A-2v1uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 4 SER A 310
ILE A 311
VAL A 385
THR A 299
 None
 1.24A 1u70A-2v1uA:
undetectable		 1u70A-2v1uA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 4 LEU A 133
ILE A 146
ILE A  94
ALA A 114
 None
 0.87A 2i30A-2v1uA:
undetectable		 2i30A-2v1uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 ALA A 247
PRO A 212
GLY A  68
ASP A 253
LEU A 218
 None
None
ADP  A1400 (-2.2A)
None
None
 1.27A 2nv4A-2v1uA:
undetectable		 2nv4A-2v1uA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 PHE A 230
LEU A 235
ALA A 226
ALA A 229
GLU A 266
 None
 0.99A 3cwkA-2v1uA:
undetectable		 3cwkA-2v1uA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		3 / 3 GLU A 325
SER A 310
VAL A 307
 None
 0.84A 3eeoA-2v1uA:
undetectable		 3eeoA-2v1uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 ILE A 326
VAL A 376
LEU A 309
VAL A 347
ARG A 329
 None
 1.04A 3fpjB-2v1uA:
undetectable		 3fpjB-2v1uA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 TYR A 130
LEU A 133
VAL A 115
ILE A  94
LEU A 164
 None
 1.19A 3g9eA-2v1uA:
undetectable		 3g9eA-2v1uA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 LEU A  80
VAL A 107
ILE A 146
ARG A  99
 None
 1.33A 3ik3B-2v1uA:
undetectable		 3ik3B-2v1uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 10 ALA A 384
LEU A 389
VAL A 297
ILE A 311
ILE A 359
 None
 1.07A 3jw3A-2v1uA:
undetectable		 3jw3A-2v1uA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 8 TYR A 330
ILE A 350
ILE A 351
ILE A 311
 None
 0.66A 3p4wC-2v1uA:
undetectable		 3p4wC-2v1uA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		3 / 3 GLY A  66
GLY A  68
THR A  70
 ADP  A1400 (-3.8A)
ADP  A1400 (-2.2A)
MG  A1401 ( 3.0A)
 0.43A 3si7B-2v1uA:
6.1		 3si7B-2v1uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 VAL A 115
LEU A 137
LEU A 133
ILE A 146
 None
 0.98A 3u5kB-2v1uA:
undetectable		 3u5kB-2v1uA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 LEU A 235
ARG A 225
SER A  15
VAL A  23
 None
ADP  A1400 (-3.3A)
None
None
 1.12A 4klrA-2v1uA:
undetectable		 4klrA-2v1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 LEU A 182
LEU A 148
ILE A 146
LYS A  92
ILE A  94
 None
 0.81A 4y0rA-2v1uA:
undetectable		 4y0rA-2v1uA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		3 / 5 GLY A  66
GLY A 252
GLU A 250
 ADP  A1400 (-3.8A)
None
None
 0.49A 4z2eA-2v1uA:
4.3
4z2eD-2v1uA:
undetectable		 4z2eA-2v1uA:
24.22
4z2eD-2v1uA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		3 / 3 ASN A 194
LEU A  60
PHE A 153
 None
 0.81A 5dsgA-2v1uA:
undetectable		 5dsgA-2v1uA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		5 / 12 PHE A 230
ILE A  17
HIS A 280
LEU A 235
VAL A 239
 None
 1.19A 5im2A-2v1uA:
undetectable		 5im2A-2v1uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 ARG A 225
LEU A 235
GLU A 228
ALA A 229
 ADP  A1400 (-3.3A)
None
None
None
 0.49A 5jq7A-2v1uA:
undetectable		 5jq7A-2v1uA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 7 ASP A 392
ALA A 396
GLU A 386
LEU A 306
 None
 1.00A 6ci6A-2v1uA:
2.2		 6ci6A-2v1uA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG
(Aeropyrum
pernix) 		4 / 8 ASP A 259
GLU A 287
ASP A 291
GLU A 295
 None
 1.22A 6mn4C-2v1uA:
undetectable		 6mn4C-2v1uA:
21.63