SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 PRO A  26
GLY A  85
ILE A  29
LEU A  17
VAL A  18
 None
 1.16A 1r30A-2v1wA:
undetectable		 1r30A-2v1wA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 PRO A  26
GLY A  85
ILE A  29
LEU A  17
VAL A  18
 None
 1.16A 1r30B-2v1wA:
undetectable		 1r30B-2v1wA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 10 ALA A  38
ILE A  29
LEU A  43
LEU A  17
ILE A  49
 None
 1.12A 1yi4A-2v1wA:
undetectable		 1yi4A-2v1wA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ILE A  52
LEU A  78
ALA A  38
VAL A  32
HIS A  62
 None
 1.25A 2qo6A-2v1wA:
undetectable		 2qo6A-2v1wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		4 / 7 ILE A  69
LEU A  76
ARG A  16
LEU A  43
 None
 0.95A 5b1aA-2v1wA:
undetectable
5b1aJ-2v1wA:
undetectable		 5b1aA-2v1wA:
10.44
5b1aJ-2v1wA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		4 / 7 ILE A  69
LEU A  76
ARG A  16
LEU A  43
 None
 0.92A 5b3sA-2v1wA:
undetectable
5b3sJ-2v1wA:
undetectable		 5b3sA-2v1wA:
10.44
5b3sJ-2v1wA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		4 / 5 GLY A  46
PRO A   2
GLN A  50
THR A  28
 None
 1.12A 5h5fA-2v1wA:
undetectable		 5h5fA-2v1wA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		4 / 7 ILE A  69
LEU A  76
ARG A  16
LEU A  43
 None
 0.97A 5zcpA-2v1wA:
undetectable
5zcpJ-2v1wA:
undetectable		 5zcpA-2v1wA:
10.44
5zcpJ-2v1wA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2v1w PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		4 / 7 ILE A  69
LEU A  76
ARG A  16
LEU A  43
 None
 0.94A 5zcqA-2v1wA:
undetectable
5zcqJ-2v1wA:
undetectable		 5zcqA-2v1wA:
10.44
5zcqJ-2v1wA:
14.77