SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v24'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4
(Homo
sapiens) 		4 / 4 GLY A 145
LEU A 144
GLY A 110
ARG A 109
 None
 1.44A 1j7kA-2v24A:
undetectable		 1j7kA-2v24A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4
(Homo
sapiens) 		4 / 6 ARG A 109
SER A 147
PHE A 171
PRO A 174
 None
 1.25A 3jqaB-2v24A:
undetectable		 3jqaB-2v24A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4
(Homo
sapiens) 		5 / 10 VAL A 179
LEU A 177
GLY A 116
VAL A 213
TRP A 142
 None
 1.06A 3ls4H-2v24A:
1.9		 3ls4H-2v24A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4
(Homo
sapiens) 		3 / 3 HIS A  78
HIS A  76
HIS A 219
 NI  A1234 (-3.1A)
NI  A1234 (-3.3A)
NI  A1234 (-3.3A)
 0.81A 3mihA-2v24A:
3.6		 3mihA-2v24A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4
(Homo
sapiens) 		4 / 6 SER A 147
TYR A 161
PHE A 164
PHE A 171
 None
 1.33A 4awuA-2v24A:
0.0		 4awuA-2v24A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4
(Homo
sapiens) 		3 / 3 SER A 147
ALA A 160
VAL A 159
 None
 0.64A 4x20C-2v24A:
undetectable		 4x20C-2v24A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4
(Homo
sapiens) 		3 / 3 ASP A 193
ASN A 103
GLN A 101
 None
 0.76A 5k7uA-2v24A:
undetectable		 5k7uA-2v24A:
23.63