SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 7 LEU A 163
ILE A 159
ALA A 170
ILE A 104
 None
 0.88A 1oniB-2v25A:
undetectable
1oniC-2v25A:
undetectable		 1oniB-2v25A:
20.08
1oniC-2v25A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 10 TYR A 156
GLU A  39
TYR A 198
ASP A 174
VAL A 173
 ASP  A1234 (-4.5A)
None
None
ASP  A1234 (-2.8A)
None
 1.47A 1qftA-2v25A:
0.0		 1qftA-2v25A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 10 TYR A 156
GLU A  39
TYR A 198
ASP A 174
VAL A 173
 ASP  A1234 (-4.5A)
None
None
ASP  A1234 (-2.8A)
None
 1.47A 1qftB-2v25A:
0.0		 1qftB-2v25A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFV_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 10 TYR A 156
GLU A  39
TYR A 198
ASP A 174
VAL A 173
 ASP  A1234 (-4.5A)
None
None
ASP  A1234 (-2.8A)
None
 1.46A 1qfvA-2v25A:
0.0		 1qfvA-2v25A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFV_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 10 TYR A 156
GLU A  39
TYR A 198
ASP A 174
VAL A 173
 ASP  A1234 (-4.5A)
None
None
ASP  A1234 (-2.8A)
None
 1.46A 1qfvB-2v25A:
0.0		 1qfvB-2v25A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 7 ILE A  80
LYS A  19
ILE A 188
ASP A 174
 None
ASP  A1234 (-2.9A)
None
ASP  A1234 (-2.8A)
 0.81A 1uwjA-2v25A:
undetectable		 1uwjA-2v25A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 12 LEU A  14
ILE A   8
ALA A  43
VAL A  42
THR A 202
 None
 1.42A 2qo4A-2v25A:
undetectable		 2qo4A-2v25A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 8 ASP A 174
SER A 176
ILE A 177
ASP A 102
 ASP  A1234 (-2.8A)
None
None
None
 0.98A 2xadA-2v25A:
undetectable		 2xadA-2v25A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 8 ASP A 174
SER A 176
ILE A 177
ASP A 102
 ASP  A1234 (-2.8A)
None
None
None
 0.98A 2xadB-2v25A:
undetectable		 2xadB-2v25A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 8 ASP A 174
SER A 176
ILE A 177
ASP A 102
 ASP  A1234 (-2.8A)
None
None
None
 1.02A 2xadC-2v25A:
undetectable		 2xadC-2v25A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 8 ASP A 174
SER A 176
ILE A 177
ASP A 102
 ASP  A1234 (-2.8A)
None
None
None
 0.98A 2xadD-2v25A:
undetectable		 2xadD-2v25A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		3 / 3 TYR A 198
GLU A  39
ASN A  20
 None
 0.92A 2y7hC-2v25A:
undetectable		 2y7hC-2v25A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 12 ILE A 104
THR A 132
PHE A 153
PRO A 154
TYR A 198
 None
ASP  A1234 (-3.4A)
None
None
None
 1.28A 3cl9A-2v25A:
undetectable		 3cl9A-2v25A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G7X_A_HSMA174_1
(FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 10 TYR A 156
GLU A  39
TYR A 198
ASP A 174
VAL A 173
 ASP  A1234 (-4.5A)
None
None
ASP  A1234 (-2.8A)
None
 1.46A 3g7xA-2v25A:
0.0		 3g7xA-2v25A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G7X_B_HSMB176_1
(FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 10 TYR A 156
GLU A  39
TYR A 198
ASP A 174
VAL A 173
 ASP  A1234 (-4.5A)
None
None
ASP  A1234 (-2.8A)
None
 1.46A 3g7xB-2v25A:
0.0		 3g7xB-2v25A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 6 VAL A  18
LEU A 179
ILE A  57
ILE A  80
 None
 0.89A 3gcsA-2v25A:
undetectable		 3gcsA-2v25A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		3 / 3 LYS A  11
ILE A 200
PHE A  95
 None
 0.79A 3j7zS-2v25A:
undetectable
3j7za-2v25A:
undetectable		 3j7zS-2v25A:
20.25
3j7za-2v25A:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 6 PHE A 150
ASN A 124
ALA A 123
LEU A 106
 None
 0.89A 4ejgD-2v25A:
undetectable		 4ejgD-2v25A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		4 / 8 ILE A 137
LEU A 109
LEU A 189
MET A 120
 None
 0.97A 4r38B-2v25A:
undetectable		 4r38B-2v25A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		3 / 3 LYS A 160
LYS A 185
SER A 186
 None
 1.43A 5odiA-2v25A:
undetectable		 5odiA-2v25A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2v25 MAJOR CELL-BINDING
FACTOR
(Campylobacter
jejuni) 		5 / 12 PHE A 171
LEU A 117
SER A 186
VAL A 182
ILE A 188
 None
 1.46A 6bxnB-2v25A:
3.1		 6bxnB-2v25A:
23.39