SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 MET A 320
PRO A 187
GLU A 190
ASP A 313
 None
 1.24A 1dtlA-2v26A:
undetectable		 1dtlA-2v26A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 PHE A 483
PHE A 665
GLY A 453
SER A 146
GLY A 662
 None
 1.11A 1igxA-2v26A:
undetectable		 1igxA-2v26A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 TYR A  81
THR A 676
TYR A 100
LEU A 673
 None
None
ADP  A1789 (-4.3A)
EDO  A1794 (-4.8A)
 0.99A 1uw6A-2v26A:
undetectable
1uw6B-2v26A:
undetectable		 1uw6A-2v26A:
12.33
1uw6B-2v26A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 TYR A  81
THR A 676
TYR A 100
LEU A 673
 None
None
ADP  A1789 (-4.3A)
EDO  A1794 (-4.8A)
 1.02A 1uw6D-2v26A:
undetectable
1uw6E-2v26A:
undetectable		 1uw6D-2v26A:
12.33
1uw6E-2v26A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 TYR A  81
THR A 676
TYR A 100
LEU A 673
 None
None
ADP  A1789 (-4.3A)
EDO  A1794 (-4.8A)
 1.01A 1uw6G-2v26A:
undetectable
1uw6H-2v26A:
undetectable		 1uw6G-2v26A:
12.33
1uw6H-2v26A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 TYR A  81
THR A 676
TYR A 100
LEU A 673
 None
None
ADP  A1789 (-4.3A)
EDO  A1794 (-4.8A)
 1.01A 1uw6P-2v26A:
undetectable
1uw6Q-2v26A:
undetectable		 1uw6P-2v26A:
12.33
1uw6Q-2v26A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 LEU A 673
TYR A  81
THR A 676
TYR A 100
 EDO  A1794 (-4.8A)
None
None
ADP  A1789 (-4.3A)
 1.00A 1uw6P-2v26A:
undetectable
1uw6T-2v26A:
undetectable		 1uw6P-2v26A:
12.33
1uw6T-2v26A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 9 PHE A 317
PHE A 192
VAL A 435
MET A 320
LEU A 337
 None
 1.40A 1wrkA-2v26A:
undetectable
1wrkB-2v26A:
1.0		 1wrkA-2v26A:
8.47
1wrkB-2v26A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 9 VAL A 435
LEU A 188
PHE A 616
PHE A 317
LEU A 329
 None
 1.36A 1wrkA-2v26A:
undetectable
1wrkB-2v26A:
1.0		 1wrkA-2v26A:
8.47
1wrkB-2v26A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 LEU A 501
PHE A 757
PHE A 766
LEU A 141
 None
 1.04A 1wrlC-2v26A:
undetectable
1wrlD-2v26A:
undetectable		 1wrlC-2v26A:
8.47
1wrlD-2v26A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ALA A 191
MET A 320
LEU A 329
ILE A 327
PHE A 338
 None
 1.40A 1y0xX-2v26A:
undetectable		 1y0xX-2v26A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 ILE A 247
PHE A 432
TYR A 428
ARG A 234
GLY A 193
 None
 1.21A 2bxmA-2v26A:
2.6		 2bxmA-2v26A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2v26 MYOSIN VI
(Sus
scrofa) 		3 / 3 ASP A 102
TYR A 107
LYS A 162
 ADP  A1789 (-4.5A)
None
None
 1.22A 2othA-2v26A:
undetectable		 2othA-2v26A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 LEU A 411
SER A 604
LEU A 605
HIS A 602
 None
 0.87A 2q0iA-2v26A:
undetectable		 2q0iA-2v26A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 LEU A 742
LEU A 744
ILE A 769
PHE A 758
LEU A 714
 None
 1.03A 2q6hA-2v26A:
2.3		 2q6hA-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 7 SER A 150
ARG A 667
PHE A 665
ILE A 488
 None
 1.02A 2q6hA-2v26A:
2.3		 2q6hA-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 LEU A 742
LEU A 744
ILE A 769
PHE A 758
LEU A 714
 None
 1.01A 2qb4A-2v26A:
1.4		 2qb4A-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 7 ILE A 247
PHE A 338
ILE A 259
PHE A 317
 None
 1.24A 2qb4A-2v26A:
1.4		 2qb4A-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 7 SER A 150
ARG A 667
PHE A 665
ILE A 488
 None
 1.04A 2qb4A-2v26A:
1.4		 2qb4A-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 LEU A 742
LEU A 744
ILE A 769
PHE A 758
LEU A 714
 None
 1.03A 2qeiA-2v26A:
2.0		 2qeiA-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 SER A 150
ARG A 667
PHE A 665
ILE A 488
 None
 1.12A 2qeiA-2v26A:
2.0		 2qeiA-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 LEU A 742
LEU A 744
ILE A 769
PHE A 758
LEU A 714
 None
 1.00A 2qjuA-2v26A:
2.4		 2qjuA-2v26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 ILE A 247
PHE A 432
TYR A 428
GLY A 193
 None
 0.95A 2vdbA-2v26A:
undetectable		 2vdbA-2v26A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.14A 3ko0A-2v26A:
undetectable
3ko0B-2v26A:
undetectable
3ko0C-2v26A:
undetectable
3ko0D-2v26A:
undetectable		 3ko0A-2v26A:
9.24
3ko0B-2v26A:
9.24
3ko0C-2v26A:
9.24
3ko0D-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 PHE A 751
LEU A 738
ILE A 769
PHE A 705
ASP A 748
 None
 1.21A 3ko0A-2v26A:
undetectable
3ko0B-2v26A:
1.5
3ko0C-2v26A:
0.1
3ko0D-2v26A:
0.1		 3ko0A-2v26A:
9.24
3ko0B-2v26A:
9.24
3ko0C-2v26A:
9.24
3ko0D-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.16A 3ko0C-2v26A:
0.1
3ko0D-2v26A:
0.1
3ko0E-2v26A:
0.1
3ko0F-2v26A:
0.1		 3ko0C-2v26A:
9.24
3ko0D-2v26A:
9.24
3ko0E-2v26A:
9.24
3ko0F-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 PHE A 751
LEU A 738
ILE A 769
PHE A 705
ASP A 748
 None
 1.14A 3ko0C-2v26A:
0.1
3ko0D-2v26A:
undetectable
3ko0E-2v26A:
1.5
3ko0F-2v26A:
0.1		 3ko0C-2v26A:
9.24
3ko0D-2v26A:
9.24
3ko0E-2v26A:
9.24
3ko0F-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.14A 3ko0E-2v26A:
0.1
3ko0F-2v26A:
0.1
3ko0G-2v26A:
0.9
3ko0H-2v26A:
undetectable		 3ko0E-2v26A:
9.24
3ko0F-2v26A:
9.24
3ko0G-2v26A:
9.24
3ko0H-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.20A 3ko0G-2v26A:
0.9
3ko0H-2v26A:
undetectable
3ko0I-2v26A:
1.5
3ko0J-2v26A:
1.4		 3ko0G-2v26A:
9.24
3ko0H-2v26A:
9.24
3ko0I-2v26A:
9.24
3ko0J-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 PHE A 751
LEU A 738
ILE A 769
PHE A 705
ASP A 748
 None
 1.19A 3ko0G-2v26A:
undetectable
3ko0H-2v26A:
undetectable
3ko0I-2v26A:
undetectable
3ko0J-2v26A:
undetectable		 3ko0G-2v26A:
9.24
3ko0H-2v26A:
9.24
3ko0I-2v26A:
9.24
3ko0J-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.15A 3ko0A-2v26A:
undetectable
3ko0B-2v26A:
undetectable
3ko0I-2v26A:
undetectable
3ko0J-2v26A:
undetectable		 3ko0A-2v26A:
9.24
3ko0B-2v26A:
9.24
3ko0I-2v26A:
9.24
3ko0J-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.18A 3ko0K-2v26A:
undetectable
3ko0L-2v26A:
undetectable
3ko0S-2v26A:
1.5
3ko0T-2v26A:
undetectable		 3ko0K-2v26A:
9.24
3ko0L-2v26A:
9.24
3ko0S-2v26A:
9.24
3ko0T-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.12A 3ko0K-2v26A:
undetectable
3ko0L-2v26A:
undetectable
3ko0M-2v26A:
undetectable
3ko0N-2v26A:
undetectable		 3ko0K-2v26A:
9.24
3ko0L-2v26A:
9.24
3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.14A 3ko0M-2v26A:
undetectable
3ko0N-2v26A:
undetectable
3ko0O-2v26A:
undetectable
3ko0P-2v26A:
undetectable		 3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
3ko0O-2v26A:
9.24
3ko0P-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.19A 3ko0K-2v26A:
1.5
3ko0L-2v26A:
undetectable
3ko0M-2v26A:
1.5
3ko0N-2v26A:
0.1		 3ko0K-2v26A:
9.24
3ko0L-2v26A:
9.24
3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.16A 3ko0O-2v26A:
undetectable
3ko0P-2v26A:
undetectable
3ko0Q-2v26A:
1.0
3ko0R-2v26A:
1.4		 3ko0O-2v26A:
9.24
3ko0P-2v26A:
9.24
3ko0Q-2v26A:
9.24
3ko0R-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.09A 3ko0M-2v26A:
undetectable
3ko0N-2v26A:
undetectable
3ko0O-2v26A:
undetectable
3ko0P-2v26A:
undetectable		 3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
3ko0O-2v26A:
9.24
3ko0P-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 10 PHE A 751
LEU A 738
ILE A 769
PHE A 705
ASP A 748
 None
 1.16A 3ko0O-2v26A:
undetectable
3ko0P-2v26A:
undetectable
3ko0Q-2v26A:
1.0
3ko0R-2v26A:
0.1		 3ko0O-2v26A:
9.24
3ko0P-2v26A:
9.24
3ko0Q-2v26A:
9.24
3ko0R-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 11 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.14A 3ko0Q-2v26A:
undetectable
3ko0R-2v26A:
1.4
3ko0S-2v26A:
1.5
3ko0T-2v26A:
undetectable		 3ko0Q-2v26A:
9.24
3ko0R-2v26A:
9.24
3ko0S-2v26A:
9.24
3ko0T-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 THR A 369
LEU A 372
GLN A 383
ARG A 387
 None
 1.14A 3kp2A-2v26A:
undetectable
3kp2B-2v26A:
undetectable		 3kp2A-2v26A:
11.73
3kp2B-2v26A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 LEU A 386
ARG A 387
THR A 391
GLY A 348
 None
 0.91A 3ny4A-2v26A:
undetectable		 3ny4A-2v26A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 VAL A 341
TYR A 428
TYR A 245
ILE A 259
TYR A 249
 None
 1.43A 3q5pA-2v26A:
undetectable		 3q5pA-2v26A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ILE A 147
SER A 146
GLY A 453
SER A 144
THR A 661
 None
 1.14A 3r75A-2v26A:
2.0		 3r75A-2v26A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ILE A 147
SER A 146
GLY A 453
SER A 144
THR A 661
 None
 1.15A 3r75B-2v26A:
2.0		 3r75B-2v26A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 ALA A 424
VAL A 427
LEU A 431
LEU A 345
 None
 0.83A 3roxA-2v26A:
undetectable		 3roxA-2v26A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2v26 MYOSIN VI
(Sus
scrofa) 		3 / 3 GLY A 154
GLY A 156
THR A 158
 ADP  A1789 ( 3.5A)
ADP  A1789 (-3.1A)
MG  A1801 ( 3.0A)
 0.44A 3si7B-2v26A:
undetectable		 3si7B-2v26A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		3 / 3 TYR A  81
LEU A  68
ARG A  80
 None
 0.65A 3sufB-2v26A:
undetectable		 3sufB-2v26A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 7 ALA A 283
TYR A 281
ARG A 250
ALA A 253
 None
 1.15A 3twpA-2v26A:
undetectable		 3twpA-2v26A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		3 / 3 GLY A 277
THR A 279
ASN A 275
 None
 0.65A 3v4tD-2v26A:
undetectable		 3v4tD-2v26A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		3 / 3 LYS A 162
ARG A 250
LEU A 310
 None
None
ADP  A1789 (-4.3A)
 1.02A 3v4tE-2v26A:
undetectable		 3v4tE-2v26A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ASN A  62
LEU A 689
ASN A  92
VAL A 697
LEU A  73
 None
 0.91A 3vaqB-2v26A:
undetectable		 3vaqB-2v26A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 LEU A 480
LEU A 455
ILE A 515
GLN A 512
GLU A 486
 None
 1.38A 3w1wB-2v26A:
undetectable		 3w1wB-2v26A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 GLU A 478
ILE A 515
PHE A 582
VAL A 697
 None
 1.15A 4a97I-2v26A:
2.5		 4a97I-2v26A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ASN A  62
LEU A 689
ASN A  92
VAL A 697
LEU A  73
 None
 0.94A 4dc3A-2v26A:
undetectable		 4dc3A-2v26A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 4 ALA A  91
VAL A  90
ASP A  61
LEU A  68
 None
 1.00A 4e7gA-2v26A:
undetectable		 4e7gA-2v26A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 ILE A 571
HIS A 581
ILE A 525
VAL A 547
 None
 0.98A 4zj8A-2v26A:
2.1		 4zj8A-2v26A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 10 PHE A 192
ALA A 191
VAL A 341
LEU A 263
PHE A 317
 None
 1.33A 4zmeB-2v26A:
undetectable		 4zmeB-2v26A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 7 LEU A 143
GLY A 662
ALA A 663
SER A 146
 None
 0.82A 5f1aB-2v26A:
undetectable		 5f1aB-2v26A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 VAL A 164
SER A 664
ILE A 488
PHE A 484
 None
 0.87A 5jw1A-2v26A:
undetectable		 5jw1A-2v26A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 VAL A 164
SER A 664
ILE A 488
PHE A 484
 None
 0.90A 5jw1B-2v26A:
undetectable		 5jw1B-2v26A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2v26 MYOSIN VI
(Sus
scrofa) 		3 / 3 VAL A 149
ARG A  85
PRO A 125
 None
 0.75A 5koxA-2v26A:
undetectable		 5koxA-2v26A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 LEU A 686
ILE A  95
VAL A 695
LEU A 698
VAL A  90
 None
 1.09A 5mugA-2v26A:
undetectable		 5mugA-2v26A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 7 SER A 604
ALA A 419
ILE A 350
LEU A 347
 None
 1.02A 5te8A-2v26A:
undetectable		 5te8A-2v26A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 7 SER A 604
ALA A 419
ILE A 350
LEU A 347
 None
 0.88A 5te8C-2v26A:
undetectable		 5te8C-2v26A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 8 ARG A 667
ALA A 155
THR A 161
GLY A 459
 None
ADP  A1789 (-4.2A)
None
VO4  A1791 (-3.3A)
 0.90A 5v0vA-2v26A:
1.8		 5v0vA-2v26A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 ILE A 641
ILE A 609
LEU A 605
HIS A 602
 None
 1.02A 5vkqA-2v26A:
undetectable
5vkqB-2v26A:
undetectable		 5vkqA-2v26A:
18.81
5vkqB-2v26A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 ILE A 641
ILE A 609
LEU A 605
HIS A 602
 None
 1.03A 5vkqB-2v26A:
undetectable
5vkqC-2v26A:
undetectable		 5vkqB-2v26A:
18.81
5vkqC-2v26A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 ILE A 641
ILE A 609
LEU A 605
HIS A 602
 None
 1.01A 5vkqC-2v26A:
undetectable
5vkqD-2v26A:
undetectable		 5vkqC-2v26A:
18.81
5vkqD-2v26A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2v26 MYOSIN VI
(Sus
scrofa) 		4 / 6 ILE A 641
ILE A 609
LEU A 605
HIS A 602
 None
 1.01A 5vkqA-2v26A:
undetectable
5vkqD-2v26A:
undetectable		 5vkqA-2v26A:
18.81
5vkqD-2v26A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2v26 MYOSIN VI
(Sus
scrofa) 		3 / 3 GLY A 459
ASN A 477
ARG A 667
 VO4  A1791 (-3.3A)
EDO  A1793 ( 4.6A)
None
 0.58A 5w7bD-2v26A:
undetectable		 5w7bD-2v26A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ASN A 474
PHE A 593
GLY A 576
PHE A 577
ILE A 567
 None
 1.37A 6dwnA-2v26A:
undetectable		 6dwnA-2v26A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 2v26 MYOSIN VI
(Sus
scrofa) 		5 / 12 ILE A 148
GLY A 453
PHE A 451
ILE A 457
LEU A 654
 None
None
None
EDO  A1793 ( 3.9A)
None
 1.09A 6dwnC-2v26A:
undetectable		 6dwnC-2v26A:
8.07