SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 12 GLU A 123
HIS A 127
TYR A 162
TRP A 163
GLU A 167
 None
 1.22A 1kw0A-2v28A:
26.7		 1kw0A-2v28A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 12 VAL A  82
GLU A 123
HIS A 127
TYR A 162
GLU A 167
 None
 1.04A 1kw0A-2v28A:
26.7		 1kw0A-2v28A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 11 VAL A  82
GLU A 123
HIS A 127
TYR A 162
GLU A 167
 None
 1.00A 1mmtA-2v28A:
26.8		 1mmtA-2v28A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.86A 1p7lC-2v28A:
undetectable		 1p7lC-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.85A 1p7lD-2v28A:
undetectable		 1p7lD-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.84A 1rg9A-2v28A:
undetectable		 1rg9A-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.82A 1rg9B-2v28A:
undetectable		 1rg9B-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.85A 1rg9C-2v28A:
undetectable		 1rg9C-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.83A 1rg9D-2v28A:
undetectable		 1rg9D-2v28A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 VAL A 184
THR A 165
TYR A 224
LEU A 170
 None
 1.03A 1z2bB-2v28A:
undetectable		 1z2bB-2v28A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 5 LEU A  54
LEU A  51
LEU A 130
CYH A  79
 None
 1.01A 2ab2B-2v28A:
undetectable		 2ab2B-2v28A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A 126
GLY A 181
GLU A 167
ILE A 124
CYH A 128
 None
 1.32A 2akeA-2v28A:
undetectable		 2akeA-2v28A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A 126
GLY A 181
GLU A 167
ILE A 124
CYH A 128
 None
 1.30A 2azxB-2v28A:
undetectable		 2azxB-2v28A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 11 GLY A 126
GLY A 181
GLU A 167
ILE A 124
CYH A 128
 None
 1.30A 2dr2A-2v28A:
undetectable		 2dr2A-2v28A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 PHE A 168
GLY A 169
ILE A 179
ALA A 194
 None
 0.90A 3aodA-2v28A:
undetectable		 3aodA-2v28A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		3 / 3 HIS A 122
GLU A 123
HIS A 127
 None
 0.21A 3kecB-2v28A:
undetectable		 3kecB-2v28A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 7 GLU A 117
TYR A 114
GLU A 111
TYR A   7
 None
 0.96A 3ku9B-2v28A:
undetectable		 3ku9B-2v28A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 TYR A 162
LEU A 233
TYR A 139
PHE A 136
 None
 1.29A 3po7A-2v28A:
undetectable		 3po7A-2v28A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 6 ALA A 194
ILE A 179
LEU A 170
GLU A 190
 None
 0.81A 3r9sA-2v28A:
undetectable		 3r9sA-2v28A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 ALA A 194
ILE A 179
LEU A 170
GLU A 190
 None
 0.76A 3r9tA-2v28A:
undetectable		 3r9tA-2v28A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		3 / 3 ARG A 160
PRO A 222
PHE A 164
 None
 1.05A 3thrC-2v28A:
undetectable		 3thrC-2v28A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 11 LEU A 211
ILE A 236
TYR A 139
ILE A 166
PHE A 205
 None
 1.04A 4odrA-2v28A:
undetectable
4odrB-2v28A:
undetectable		 4odrA-2v28A:
17.98
4odrB-2v28A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 6 HIS A 122
HIS A 127
TYR A 162
GLU A 167
 None
 0.64A 4pahA-2v28A:
28.1		 4pahA-2v28A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 12 ALA A 159
HIS A 122
GLU A 123
HIS A 127
GLU A 167
 None
 0.89A 4r7lA-2v28A:
undetectable		 4r7lA-2v28A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		3 / 3 GLU A 123
TYR A 162
GLU A 167
 None
 0.69A 4ryaA-2v28A:
undetectable		 4ryaA-2v28A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A 179
CYH A  44
GLY A 182
GLY A 181
 None
 0.84A 5a06A-2v28A:
undetectable		 5a06A-2v28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A 179
CYH A  44
GLY A 182
GLY A 181
 None
 0.81A 5a06B-2v28A:
undetectable		 5a06B-2v28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A 179
CYH A  44
GLY A 182
GLY A 181
 None
 0.83A 5a06C-2v28A:
undetectable		 5a06C-2v28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A 179
CYH A  44
GLY A 182
GLY A 181
 None
 0.83A 5a06E-2v28A:
undetectable		 5a06E-2v28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 TYR A 143
PHE A 136
TYR A 139
GLY A 181
 None
 0.85A 5esfA-2v28A:
undetectable		 5esfA-2v28A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 5 TYR A 225
TRP A 163
LEU A 256
LEU A 208
 None
 1.39A 5eshA-2v28A:
undetectable		 5eshA-2v28A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 4 HIS A 122
HIS A 127
TYR A 162
GLU A 167
 None
 0.64A 5pahA-2v28A:
28.0		 5pahA-2v28A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 HIS A 122
PRO A 118
THR A 140
PHE A 100
 None
 0.86A 5t8sB-2v28A:
undetectable		 5t8sB-2v28A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 8 ARG A 212
THR A 213
PRO A 214
ILE A 223
 SO4  A1268 (-3.0A)
None
None
None
 0.94A 6a4iA-2v28A:
undetectable		 6a4iA-2v28A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 9 THR A 165
GLY A 169
GLY A 181
TYR A 139
HIS A 127
 None
 1.50A 6gnfA-2v28A:
undetectable		 6gnfA-2v28A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		4 / 5 ARG A 107
LEU A  31
GLN A  29
PHE A  32
 None
 1.45A 6nmpP-2v28A:
undetectable
6nmpW-2v28A:
undetectable		 6nmpP-2v28A:
18.37
6nmpW-2v28A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2v28 PHENYLALANINE-4-HYDR
OXYLASE
(Colwellia
psychrerythraea) 		5 / 6 PRO A 118
HIS A 122
HIS A 127
TYR A 162
GLU A 167
 None
 0.59A 6pahA-2v28A:
28.0		 6pahA-2v28A:
29.34