SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2v2t TRANSCRIPTION FACTOR
RELB
(Mus
musculus) 		4 / 7 ASP A 240
SER A 275
ASN A 277
GLN A 307
 None
 1.00A 2cmlA-2v2tA:
undetectable		 2cmlA-2v2tA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2v2t TRANSCRIPTION FACTOR
RELB
(Mus
musculus) 		5 / 11 ILE A 246
GLY A 204
PHE A 118
PRO A 111
ILE A 205
 None
 1.47A 2y7kA-2v2tA:
undetectable		 2y7kA-2v2tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 2v2t TRANSCRIPTION FACTOR
RELB
(Mus
musculus) 		4 / 5 TYR A 104
PRO A 264
THR A 159
THR A 108
 None
 1.39A 3q07A-2v2tA:
undetectable		 3q07A-2v2tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 2v2t TRANSCRIPTION FACTOR
RELB
(Mus
musculus) 		4 / 5 TYR A 104
PRO A 264
THR A 159
THR A 108
 None
 1.40A 3q07B-2v2tA:
undetectable		 3q07B-2v2tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 2v2t TRANSCRIPTION FACTOR
RELB
(Mus
musculus) 		3 / 3 GLY A 184
CYH A 186
CYH A 181
 None
 0.55A 5inzB-2v2tA:
undetectable		 5inzB-2v2tA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2v2t TRANSCRIPTION FACTOR
RELB
(Mus
musculus) 		5 / 11 GLU A 121
GLY A 184
ASP A 183
PRO A 173
ARG A 219
 None
 1.13A 5yk2A-2v2tA:
undetectable		 5yk2A-2v2tA:
22.30