SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
None
None
J54  A1246 ( 4.7A)
 0.88A 1ei6C-2v35A:
undetectable		 1ei6C-2v35A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 9 GLY A 140
TRP A 141
ALA A 152
LEU A 151
GLY A 193
 None
None
None
GOL  A1250 (-4.4A)
GOL  A1250 (-3.8A)
 1.24A 1jb0A-2v35A:
undetectable		 1jb0A-2v35A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 12 GLY A  44
GLY A 196
GLY A 211
ILE A  31
VAL A  52
 None
 0.97A 2oxtC-2v35A:
undetectable		 2oxtC-2v35A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2v35 ELASTASE-1
(Sus
scrofa) 		3 / 3 LEU A 105
TRP A  94
TYR A 234
 None
 1.01A 3aicA-2v35A:
undetectable		 3aicA-2v35A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2v35 ELASTASE-1
(Sus
scrofa) 		3 / 3 LEU A 105
TRP A  94
TYR A 234
 None
 1.00A 3aicE-2v35A:
undetectable		 3aicE-2v35A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2v35 ELASTASE-1
(Sus
scrofa) 		3 / 3 LEU A 105
TRP A  94
TYR A 234
 None
 1.01A 3aicF-2v35A:
undetectable		 3aicF-2v35A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2v35 ELASTASE-1
(Sus
scrofa) 		3 / 3 LEU A 105
TRP A  94
TYR A 234
 None
 0.98A 3aicG-2v35A:
undetectable		 3aicG-2v35A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2v35 ELASTASE-1
(Sus
scrofa) 		3 / 3 LEU A 105
TRP A  94
TYR A 234
 None
 1.00A 3aicH-2v35A:
undetectable		 3aicH-2v35A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2v35 ELASTASE-1
(Sus
scrofa) 		4 / 4 PRO A 225
THR A 226
GLY A  19
THR A  20
 None
 1.11A 3ib1A-2v35A:
undetectable		 3ib1A-2v35A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 9 GLY A 140
TRP A 141
ALA A 152
LEU A 151
GLY A 193
 None
None
None
GOL  A1250 (-4.4A)
GOL  A1250 (-3.8A)
 1.24A 3pcqA-2v35A:
undetectable		 3pcqA-2v35A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 12 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.85A 3pghC-2v35A:
undetectable		 3pghC-2v35A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 12 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.77A 3rr3A-2v35A:
undetectable		 3rr3A-2v35A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 12 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.76A 3rr3B-2v35A:
undetectable		 3rr3B-2v35A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 11 VAL A  16
SER A  29
LEU A 199
VAL A 212
THR A 213
 None
 1.38A 3tbgA-2v35A:
undetectable		 3tbgA-2v35A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2v35 ELASTASE-1
(Sus
scrofa) 		4 / 6 TYR A 101
GLY A 100
SER A 179
THR A 229
 None
 1.13A 3tj7C-2v35A:
undetectable
3tj7D-2v35A:
undetectable		 3tj7C-2v35A:
22.51
3tj7D-2v35A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 2v35 ELASTASE-1
(Sus
scrofa) 		6 / 12 GLY A 142
GLY A  44
GLY A 197
GLY A 193
VAL A  52
ILE A  31
 None
None
None
GOL  A1250 (-3.8A)
None
None
 1.26A 4ctkC-2v35A:
undetectable		 4ctkC-2v35A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		4 / 7 ASP A  77
GLU A  80
VAL A  67
GLU A  70
 NA  A1247 (-3.3A)
NA  A1247 (-3.4A)
None
NA  A1247 (-2.9A)
 0.86A 4hvrA-2v35A:
undetectable		 4hvrA-2v35A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		6 / 12 GLY A 142
GLY A  44
GLY A 197
GLY A 193
VAL A  52
ILE A  31
 None
None
None
GOL  A1250 (-3.8A)
None
None
 1.25A 5eiwC-2v35A:
undetectable		 5eiwC-2v35A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		6 / 12 GLY A 142
GLY A  44
GLY A 197
GLY A 193
VAL A  52
ILE A  31
 None
None
None
GOL  A1250 (-3.8A)
None
None
 1.24A 5ekxB-2v35A:
undetectable		 5ekxB-2v35A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		3 / 3 ASN A 133
ASP A 186
GLY A 185
 None
 0.62A 5fctB-2v35A:
undetectable		 5fctB-2v35A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 12 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.78A 5iktA-2v35A:
undetectable		 5iktA-2v35A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 2v35 ELASTASE-1
(Sus
scrofa) 		6 / 12 GLY A 142
GLY A  44
GLY A 197
GLY A 193
VAL A  52
ILE A  31
 None
None
None
GOL  A1250 (-3.8A)
None
None
 1.29A 5m5bA-2v35A:
undetectable		 5m5bA-2v35A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2v35 ELASTASE-1
(Sus
scrofa) 		5 / 11 VAL A  99
GLY A 100
SER A 179
ALA A 233
VAL A 176
 None
None
None
SO4  A1248 (-3.9A)
None
 1.03A 6hu9A-2v35A:
undetectable
6hu9E-2v35A:
undetectable
6hu9I-2v35A:
undetectable		 6hu9A-2v35A:
20.99
6hu9E-2v35A:
20.90
6hu9I-2v35A:
12.86