SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU C 217
VAL C 262
GLY C 228
GLU C 196
 None
 1.00A 1jlfA-2v3cC:
undetectable
1jlfB-2v3cC:
2.4		 1jlfA-2v3cC:
22.73
1jlfB-2v3cC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 12 THR C 265
ILE C 223
GLY C 224
GLY C 257
THR C 222
 None
 1.10A 1nv8A-2v3cC:
2.5		 1nv8A-2v3cC:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA C 190
ILE C 215
ILE C 206
GLU C 202
 None
 0.97A 1oniD-2v3cC:
undetectable
1oniF-2v3cC:
undetectable		 1oniD-2v3cC:
16.12
1oniF-2v3cC:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 11 THR C 116
GLU C 214
ILE C 241
ASP C 213
PHE C 234
 None
 1.30A 2admA-2v3cC:
undetectable		 2admA-2v3cC:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU C   5
LEU C  38
ALA C  37
LEU C  47
VAL C  48
 None
 1.17A 2bxeA-2v3cC:
3.9		 2bxeA-2v3cC:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE C 234
LEU C 185
ILE C 124
ALA C 121
LEU C 105
 None
 1.43A 2v0mA-2v3cC:
1.6		 2v0mA-2v3cC:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU C 293
ALA C  41
GLY C 256
PHE C 289
 None
 0.93A 2wq5A-2v3cC:
undetectable		 2wq5A-2v3cC:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL C 184
ILE C 124
ALA C 117
ILE C 154
VAL C 156
 None
 1.09A 3me6A-2v3cC:
undetectable		 3me6A-2v3cC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 11 ALA C 136
ASP C 137
PRO C 212
VAL C 102
ILE C 187
 None
 1.34A 3oxxB-2v3cC:
undetectable		 3oxxB-2v3cC:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE C 215
ILE C 216
VAL C 238
ILE C 244
 None
 0.88A 3p4wC-2v3cC:
2.8		 3p4wC-2v3cC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE C 229
GLY C 107
ALA C 233
GLU C 196
 None
 0.94A 4g0uB-2v3cC:
undetectable		 4g0uB-2v3cC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE C 289
GLY C 221
GLY C 224
LEU C 259
SER C 260
 None
 1.05A 4krhB-2v3cC:
3.9		 4krhB-2v3cC:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP C 285
LYS C  92
LEU C  95
 None
 1.04A 4ptjA-2v3cC:
3.9		 4ptjA-2v3cC:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU C  60
ARG C  58
ILE C  55
ILE C  77
 None
 1.42A 5dzk2-2v3cC:
undetectable
5dzkM-2v3cC:
undetectable
5dzkN-2v3cC:
undetectable		 5dzk2-2v3cC:
2.35
5dzkM-2v3cC:
20.75
5dzkN-2v3cC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE C 289
GLY C  87
SER C 260
LEU C  38
LEU C 249
 None
 1.09A 5ji0D-2v3cC:
undetectable		 5ji0D-2v3cC:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE C 154
LEU C  93
ILE C 186
LEU C 105
VAL C 218
 None
 0.97A 5mugA-2v3cC:
undetectable		 5mugA-2v3cC:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA C 143
GLN C 109
THR C 114
 None
 0.73A 5n0oA-2v3cC:
undetectable		 5n0oA-2v3cC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE C 108
LEU C 199
MET C 203
LEU C 200
 None
 1.01A 5u4sA-2v3cC:
4.8		 5u4sA-2v3cC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE C 108
LEU C 199
MET C 203
LEU C 200
 None
 0.98A 5u4sB-2v3cC:
2.3		 5u4sB-2v3cC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL C 172
GLU C 174
ILE C 209
 None
 0.66A 6f7lB-2v3cC:
undetectable		 6f7lB-2v3cC:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2v3c SIGNAL RECOGNITION
54 KDA PROTEIN
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS C  73
ARG C  58
ILE C  77
 None
 0.81A 6fgdA-2v3cC:
2.6		 6fgdA-2v3cC:
22.17