SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 8 ASP A 459
VAL A 482
PHE A 452
LEU A 436
 None
 1.01A 4f8hA-2v3sA:
undetectable
4f8hB-2v3sA:
undetectable		 4f8hA-2v3sA:
22.16
4f8hB-2v3sA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 8 ASP A 459
VAL A 482
PHE A 452
LEU A 436
 None
 1.02A 4f8hC-2v3sA:
undetectable
4f8hD-2v3sA:
undetectable		 4f8hC-2v3sA:
22.16
4f8hD-2v3sA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 8 ASP A 459
VAL A 482
PHE A 452
LEU A 436
 None
 1.01A 4f8hD-2v3sA:
undetectable
4f8hE-2v3sA:
undetectable		 4f8hD-2v3sA:
22.16
4f8hE-2v3sA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 8 ARG A 441
GLN A 523
ASN A 448
ASP A 449
 None
 1.33A 5vunA-2v3sA:
undetectable		 5vunA-2v3sA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 8 ARG A 441
GLN A 523
ASN A 448
ASP A 449
 None
 1.29A 5vunB-2v3sA:
undetectable		 5vunB-2v3sA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 8 ARG A 441
GLN A 523
ASN A 448
ASP A 449
 None
 1.28A 5vuoB-2v3sA:
undetectable		 5vuoB-2v3sA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 8 ARG A 441
GLN A 523
ASN A 448
ASP A 449
 None
 1.28A 6auuB-2v3sA:
undetectable		 6auuB-2v3sA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1
(Homo
sapiens) 		4 / 7 ASP A 478
GLY A 509
SER A 505
GLY A 506
 None
 0.83A 6ekzA-2v3sA:
undetectable		 6ekzA-2v3sA:
23.96