SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 8 GLU A 214
GLY A 215
SER A 192
ASP A 189
 None
 0.77A 1m4iA-2v40A:
undetectable		 1m4iA-2v40A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 5 ASP A 212
GLU A 214
LEU A 220
LEU A 217
 None
 1.07A 1np1A-2v40A:
undetectable		 1np1A-2v40A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 9 THR A 265
THR A 311
LEU A 258
VAL A 398
VAL A 400
 None
 1.33A 1t86B-2v40A:
undetectable		 1t86B-2v40A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 8 LEU A  49
ARG A 416
VAL A 445
GLY A 446
 None
None
None
GDP  A1457 (-3.3A)
 0.85A 2qd5A-2v40A:
undetectable		 2qd5A-2v40A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		3 / 3 LEU A 405
GLU A 435
ILE A 432
 None
 0.60A 3czhA-2v40A:
undetectable		 3czhA-2v40A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		3 / 3 TYR A 300
TYR A 428
ILE A 372
 None
 0.76A 3eteA-2v40A:
undetectable
3eteB-2v40A:
undetectable		 3eteA-2v40A:
22.46
3eteB-2v40A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		3 / 3 GLN A 313
THR A 311
LEU A 405
 None
 0.75A 3ondA-2v40A:
undetectable		 3ondA-2v40A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		3 / 3 GLN A 313
THR A 311
LEU A 405
 None
 0.76A 3ondB-2v40A:
undetectable		 3ondB-2v40A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 11 LEU A 405
ASP A 367
ILE A 365
VAL A 374
ILE A 372
 None
 1.00A 3oxxD-2v40A:
undetectable		 3oxxD-2v40A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 6 GLY A  85
VAL A  70
HIS A  68
SER A  84
 None
None
GDP  A1457 (-4.3A)
None
 1.11A 3tj7A-2v40A:
undetectable
3tj7B-2v40A:
undetectable		 3tj7A-2v40A:
17.96
3tj7B-2v40A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 6 GLY A  85
VAL A  70
HIS A  68
SER A  84
 None
None
GDP  A1457 (-4.3A)
None
 1.08A 3tj7C-2v40A:
undetectable
3tj7D-2v40A:
undetectable		 3tj7C-2v40A:
17.96
3tj7D-2v40A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 6 VAL A  70
HIS A  68
SER A  84
GLY A  85
 None
GDP  A1457 (-4.3A)
None
None
 1.11A 3tj7C-2v40A:
undetectable
3tj7D-2v40A:
undetectable		 3tj7C-2v40A:
17.96
3tj7D-2v40A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 LEU A 127
ILE A  56
GLY A  96
ILE A 129
LEU A  81
 None
 0.86A 3uj6A-2v40A:
undetectable		 3uj6A-2v40A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 LEU A 127
ILE A  56
GLY A  96
ILE A 129
LEU A  81
 None
 0.85A 3uj7B-2v40A:
undetectable		 3uj7B-2v40A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 7 ALA A 357
ILE A 438
HIS A 350
GLY A 354
 None
 0.98A 3v4tH-2v40A:
undetectable		 3v4tH-2v40A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 TRP A 340
GLY A 375
LEU A 346
LEU A 343
GLU A  41
 None
 1.10A 4lg1A-2v40A:
2.2		 4lg1A-2v40A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 TRP A 340
GLY A 375
LEU A 346
LEU A 343
GLU A  41
 None
 1.13A 4lg1B-2v40A:
undetectable		 4lg1B-2v40A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 GLY A  62
HIS A 134
GLY A  96
ILE A  95
GLY A 277
 None
 0.99A 5d4uC-2v40A:
undetectable		 5d4uC-2v40A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 GLY A  62
HIS A 134
GLY A  96
ILE A  95
GLY A 277
 None
 1.00A 5d4uD-2v40A:
undetectable		 5d4uD-2v40A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 PHE A  94
ILE A  95
VAL A 293
GLY A 234
MET A 285
 None
 1.38A 5esgA-2v40A:
undetectable		 5esgA-2v40A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		3 / 3 ASN A 255
SER A 272
SER A 271
 None
 0.68A 5gsnA-2v40A:
undetectable		 5gsnA-2v40A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 7 LEU A 343
THR A 301
THR A 302
LEU A 436
 None
 0.90A 5jq7B-2v40A:
undetectable		 5jq7B-2v40A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 7 GLY A 178
GLN A 147
TYR A 206
TYR A 170
 None
 0.78A 5vlmG-2v40A:
undetectable		 5vlmG-2v40A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 8 SER A 130
GLY A  98
ALA A 133
GLY A 282
 None
 0.65A 5vw9A-2v40A:
undetectable		 5vw9A-2v40A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 5 LEU A 366
LYS A 362
LEU A 321
GLU A 327
 None
GDP  A1457 (-3.0A)
None
None
 1.31A 5weaA-2v40A:
undetectable		 5weaA-2v40A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 GLY A 295
GLY A  35
ALA A 257
ILE A 438
LEU A 358
 None
 1.08A 6b3aA-2v40A:
undetectable		 6b3aA-2v40A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 GLY A 295
GLY A  35
ALA A 257
ILE A 438
LEU A 358
 None
 1.09A 6b3bA-2v40A:
2.0		 6b3bA-2v40A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		5 / 12 VAL A 293
VAL A 290
GLY A  98
VAL A  99
PRO A  83
 None
 1.16A 6brdC-2v40A:
undetectable		 6brdC-2v40A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 9 VAL A 231
LEU A 220
SER A 192
ASP A 183
 None
 0.85A 6c2mD-2v40A:
undetectable		 6c2mD-2v40A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens) 		4 / 8 TYR A 428
THR A 361
TYR A 300
TRP A 408
 None
GDP  A1457 ( 4.6A)
None
None
 1.34A 6cnjD-2v40A:
undetectable
6cnjE-2v40A:
undetectable		 6cnjD-2v40A:
12.85
6cnjE-2v40A:
10.97