SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		4 / 6 GLU A 155
ARG A 141
ALA A 143
ALA A 142
 None
 1.06A 3ns1C-2v4iA:
3.5		 3ns1C-2v4iA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		4 / 6 GLY A 171
VAL A 172
ASP A 150
THR A 148
 None
 1.24A 3vqrA-2v4iA:
undetectable		 3vqrA-2v4iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		4 / 5 GLY A 171
VAL A 172
ASP A 150
THR A 148
 None
 1.24A 3vqrB-2v4iA:
undetectable		 3vqrB-2v4iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		4 / 7 ILE A 146
ARG A  26
VAL A 172
MET A 174
 None
 1.17A 4f4dA-2v4iA:
undetectable		 4f4dA-2v4iA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		4 / 8 ILE A 146
ARG A  26
PRO A 177
MET A 174
 None
 1.24A 4f4dB-2v4iA:
undetectable		 4f4dB-2v4iA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		4 / 8 ILE A 146
ARG A  26
VAL A 172
MET A 174
 None
 1.18A 4f4dB-2v4iA:
undetectable		 4f4dB-2v4iA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		5 / 11 GLY A 137
ARG A 144
ALA A 145
VAL A  14
PRO A   9
 None
 1.45A 4j4vD-2v4iA:
undetectable
4j4vE-2v4iA:
undetectable		 4j4vD-2v4iA:
21.69
4j4vE-2v4iA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		3 / 3 PRO A 119
MET A 120
TYR A 118
 None
 0.98A 4qa0B-2v4iA:
undetectable		 4qa0B-2v4iA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		3 / 3 PRO A 119
MET A 120
TYR A 118
 None
 1.01A 4qa0A-2v4iA:
undetectable		 4qa0A-2v4iA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		3 / 3 PRO A 119
MET A 120
TYR A 118
 None
 0.93A 4qa2B-2v4iA:
undetectable		 4qa2B-2v4iA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		5 / 10 GLU A  59
ALA A  50
GLU A  85
GLY A  51
ILE A 108
 None
 1.19A 6bniA-2v4iA:
undetectable		 6bniA-2v4iA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN
(Streptomyces
clavuligerus) 		5 / 10 GLU A  59
ALA A  50
GLU A  85
GLY A  51
ILE A 108
 None
 1.21A 6bniB-2v4iA:
undetectable		 6bniB-2v4iA:
13.79