SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		3 / 3 ASP A 213
ASP A 218
ASN A  96
 None
None
PO4  A1257 (-3.2A)
 0.61A 2bm9D-2v4nA:
undetectable		 2bm9D-2v4nA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		4 / 4 LEU A 227
SER A 124
ASP A 213
ASP A 207
 None
 1.18A 2br4B-2v4nA:
undetectable		 2br4B-2v4nA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		5 / 10 ALA A 140
VAL A 158
VAL A 160
PRO A 161
VAL A 224
 None
 1.04A 2nnjA-2v4nA:
undetectable		 2nnjA-2v4nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		4 / 5 ARG A 172
ALA A 216
ASP A 218
GLU A 219
 None
 1.29A 2xrzA-2v4nA:
1.8		 2xrzA-2v4nA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		3 / 3 SER A 104
GLY A 105
THR A 106
 PO4  A1257 ( 3.9A)
None
None
 0.21A 3k9wA-2v4nA:
2.5		 3k9wA-2v4nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		5 / 6 VAL A 101
SER A 223
LEU A 150
ILE A 171
LEU A 227
 None
 1.33A 3kk6A-2v4nA:
undetectable		 3kk6A-2v4nA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		5 / 6 VAL A 101
SER A 223
LEU A 150
ILE A 171
LEU A 227
 None
 1.34A 3kk6B-2v4nA:
undetectable		 3kk6B-2v4nA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		3 / 3 SER A 104
ASP A 213
ASP A 218
 PO4  A1257 ( 3.9A)
None
None
 0.87A 3uj7A-2v4nA:
undetectable		 3uj7A-2v4nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		5 / 9 ALA A  33
PRO A  34
GLY A 105
ASN A   7
SER A   6
 None
 1.14A 4a3uA-2v4nA:
undetectable		 4a3uA-2v4nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		3 / 3 SER A 104
ASP A 213
ASP A 218
 PO4  A1257 ( 3.9A)
None
None
 0.86A 4mwzA-2v4nA:
undetectable		 4mwzA-2v4nA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		3 / 3 ASP A  99
GLY A 177
ASP A 213
 None
 0.62A 4xdtA-2v4nA:
0.4		 4xdtA-2v4nA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		7 / 10 GLY A  40
ASN A  96
ASP A 100
TYR A 103
ALA A 182
ILE A 199
PRO A 202
 PO4  A1257 ( 4.2A)
PO4  A1257 (-3.2A)
GOL  A1256 ( 3.7A)
GOL  A1256 ( 4.8A)
GOL  A1256 ( 3.9A)
None
GOL  A1256 ( 4.3A)
 0.72A 4xj7A-2v4nA:
40.6
4xj7B-2v4nA:
40.4		 4xj7A-2v4nA:
99.61
4xj7B-2v4nA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		8 / 10 GLY A  40
ASN A  96
ASP A 100
TYR A 103
SER A 104
ALA A 182
ILE A 199
PRO A 202
 PO4  A1257 ( 4.2A)
PO4  A1257 (-3.2A)
GOL  A1256 ( 3.7A)
GOL  A1256 ( 4.8A)
PO4  A1257 ( 3.9A)
GOL  A1256 ( 3.9A)
None
GOL  A1256 ( 4.3A)
 0.60A 4xj7C-2v4nA:
41.2
4xj7D-2v4nA:
41.6		 4xj7C-2v4nA:
99.61
4xj7D-2v4nA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		4 / 7 GLY A  15
GLY A  90
SER A  89
ASP A   9
 None
None
None
MG  A1254 (-2.7A)
 0.76A 5ergB-2v4nA:
2.2		 5ergB-2v4nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		5 / 11 ASN A  96
VAL A  88
SER A  89
THR A 106
LEU A 142
 PO4  A1257 (-3.2A)
None
None
None
None
 1.42A 5jh7B-2v4nA:
undetectable		 5jh7B-2v4nA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2v4n MULTIFUNCTIONAL
PROTEIN SUR E
(Salmonella
enterica) 		5 / 11 ASN A  96
VAL A  88
SER A  89
THR A 106
LEU A 142
 PO4  A1257 (-3.2A)
None
None
None
None
 1.31A 5jh7D-2v4nA:
2.6		 5jh7D-2v4nA:
19.65