SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2v4v GH59 GALACTOSIDASE
([Clostridium]
cellulolyticum) 		4 / 8 LEU A1043
VAL A1004
CYH A1002
GLY A 985
 None
 1.00A 1jlfA-2v4vA:
undetectable
1jlfB-2v4vA:
undetectable		 1jlfA-2v4vA:
14.15
1jlfB-2v4vA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2v4v GH59 GALACTOSIDASE
([Clostridium]
cellulolyticum) 		4 / 6 ASN A1042
SER A 980
ALA A 979
ASP A1009
 XYP  A3051 (-3.0A)
None
None
None
 1.28A 3aruA-2v4vA:
2.3		 3aruA-2v4vA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2v4v GH59 GALACTOSIDASE
([Clostridium]
cellulolyticum) 		5 / 10 GLY A 972
ALA A 924
VAL A 971
GLU A1050
VAL A1020
 None
 1.10A 4da7A-2v4vA:
undetectable		 4da7A-2v4vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2v4v GH59 GALACTOSIDASE
([Clostridium]
cellulolyticum) 		4 / 8 SER A 932
GLU A 929
ILE A 989
VAL A1020
 None
NA  A3052 (-3.4A)
None
None
 0.94A 4dx7B-2v4vA:
undetectable		 4dx7B-2v4vA:
7.90