SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 8 MET A  91
LEU A 226
VAL A  51
GLY A  52
 None
 1.05A 1hrkA-2v4yA:
3.7		 1hrkA-2v4yA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 8 MET A  91
LEU A 226
VAL A  51
GLY A  52
 None
 1.01A 1hrkB-2v4yA:
4.1		 1hrkB-2v4yA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 SER A 135
SER A 106
ILE A 108
LEU A  82
GLY A  80
 None
 0.93A 1uakA-2v4yA:
undetectable		 1uakA-2v4yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 8 MET A  91
LEU A 226
VAL A  51
GLY A  52
 None
 0.88A 2po5B-2v4yA:
2.8		 2po5B-2v4yA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 LEU A  21
GLY A  56
GLY A  18
ALA A  83
THR A  84
 None
GTP  A1243 (-3.3A)
GTP  A1243 (-3.5A)
None
None
 1.14A 3dh0B-2v4yA:
undetectable		 3dh0B-2v4yA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		3 / 3 THR A 138
GLU A 155
HIS A 211
 None
 0.77A 3g1uB-2v4yA:
3.1		 3g1uB-2v4yA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 ILE A  33
PHE A 218
ARG A 227
LEU A 226
ALA A 225
 None
 1.30A 3lw5B-2v4yA:
undetectable		 3lw5B-2v4yA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 148
THR A 145
LEU A  21
MET A  91
LEU A  16
 None
GTP  A1243 (-4.5A)
None
None
None
 1.25A 3s79A-2v4yA:
undetectable		 3s79A-2v4yA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 7 LEU A 197
THR A 172
THR A 237
GLY A 169
 None
 0.93A 4eq4A-2v4yA:
undetectable		 4eq4A-2v4yA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 7 LEU A 197
THR A 172
THR A 237
GLY A 169
 None
 0.93A 4eqlA-2v4yA:
undetectable		 4eqlA-2v4yA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 7 LEU A 197
THR A 172
THR A 237
GLY A 169
 None
 0.91A 4eqlB-2v4yA:
undetectable		 4eqlB-2v4yA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 9 LEU A  47
VAL A  51
ILE A  12
LEU A 162
GLY A 232
 None
 1.05A 4kukA-2v4yA:
undetectable		 4kukA-2v4yA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 7 LEU A 197
THR A 172
THR A 237
GLY A 169
 None
 0.84A 4l39B-2v4yA:
undetectable		 4l39B-2v4yA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 164
ASN A  87
GLY A  18
THR A 145
VAL A  53
 None
None
GTP  A1243 (-3.5A)
GTP  A1243 (-4.5A)
None
 1.10A 4nkxD-2v4yA:
undetectable		 4nkxD-2v4yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		4 / 6 LEU A 162
LEU A 238
MET A 200
VAL A 192
 None
 1.04A 4okbA-2v4yA:
undetectable		 4okbA-2v4yA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 158
ALA A 120
ILE A 123
LEU A 134
GLY A  52
 None
 0.96A 4r38B-2v4yA:
undetectable		 4r38B-2v4yA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 GLU A  19
ASN A  59
LEU A  34
LEU A  16
MET A 220
 GTP  A1243 (-2.7A)
None
None
None
None
 1.38A 4r3aB-2v4yA:
undetectable		 4r3aB-2v4yA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 GLY A  52
VAL A  51
VAL A 131
LEU A  16
LEU A  95
 None
 1.17A 4yb6A-2v4yA:
undetectable
4yb6E-2v4yA:
undetectable		 4yb6A-2v4yA:
24.84
4yb6E-2v4yA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 GLY A  52
VAL A  51
VAL A 131
LEU A  16
LEU A  95
 None
 1.17A 4yb6B-2v4yA:
undetectable
4yb6C-2v4yA:
undetectable		 4yb6B-2v4yA:
24.84
4yb6C-2v4yA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 GLY A  52
VAL A  51
VAL A 131
LEU A  16
LEU A  95
 None
 1.19A 4yb6C-2v4yA:
undetectable
4yb6F-2v4yA:
undetectable		 4yb6C-2v4yA:
24.84
4yb6F-2v4yA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 LEU A  16
LEU A  95
GLY A  52
VAL A  51
VAL A 131
 None
 1.21A 4yb6A-2v4yA:
undetectable
4yb6D-2v4yA:
undetectable		 4yb6A-2v4yA:
24.84
4yb6D-2v4yA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 LEU A  16
LEU A  95
GLY A  52
VAL A  51
VAL A 131
 None
 1.21A 4yb6D-2v4yA:
undetectable
4yb6E-2v4yA:
undetectable		 4yb6D-2v4yA:
24.84
4yb6E-2v4yA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 LEU A  16
LEU A  95
GLY A  52
VAL A  51
VAL A 131
 None
 1.17A 4yb6B-2v4yA:
undetectable
4yb6F-2v4yA:
undetectable		 4yb6B-2v4yA:
24.84
4yb6F-2v4yA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 11 LEU A  89
VAL A  85
LEU A  21
GLY A  56
LEU A  60
 None
None
None
GTP  A1243 (-3.3A)
None
 1.27A 4zbqA-2v4yA:
undetectable		 4zbqA-2v4yA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 148
THR A 145
LEU A  21
MET A  91
LEU A  16
 None
GTP  A1243 (-4.5A)
None
None
None
 1.24A 5jkvA-2v4yA:
undetectable		 5jkvA-2v4yA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		3 / 3 ILE A  12
VAL A 230
PRO A   7
 None
 0.69A 5uunA-2v4yA:
undetectable		 5uunA-2v4yA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		3 / 3 ALA A 158
VAL A 230
TYR A   9
 None
 0.66A 5zmqH-2v4yA:
undetectable		 5zmqH-2v4yA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 208
VAL A 161
LEU A  13
VAL A 217
ILE A 215
 None
 1.12A 6dgxB-2v4yA:
undetectable		 6dgxB-2v4yA:
15.83