SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASN A 203
LEU A 205
ASP A 216
PHE A 368
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
ANP  A1480 (-4.5A)
 0.80A 1fmoE-2v55A:
4.6		 1fmoE-2v55A:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  83
VAL A  90
ALA A 103
TYR A 155
LEU A 205
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
 0.51A 1muoA-2v55A:
9.7		 1muoA-2v55A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 4 ILE A 189
LEU A 186
VAL A 182
ALA A 175
 None
 0.77A 1mz9A-2v55A:
undetectable		 1mz9A-2v55A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 ILE A 189
LEU A 186
VAL A 182
ALA A 175
 None
 0.70A 1mz9C-2v55A:
undetectable		 1mz9C-2v55A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 175
GLU A 172
LEU A 272
LEU A 317
PHE A 267
 None
 1.12A 1s9pB-2v55A:
undetectable		 1s9pB-2v55A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
LYS A 105
GLU A 124
VAL A 137
GLY A 159
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.07A 1t46A-2v55A:
18.5		 1t46A-2v55A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2v55 RHO-RELATED
GTP-BINDING PROTEIN
RHOE
(Homo
sapiens) 		5 / 12 LEU B  40
VAL B 133
GLY B 134
CYH B 177
LEU B  99
 None
 1.27A 2bxeB-2v55B:
undetectable		 2bxeB-2v55B:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ILE A  82
VAL A  90
LYS A 105
VAL A 137
ASP A 160
ASN A 203
LEU A 205
ALA A 215
 None
None
ANP  A1480 (-3.4A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.89A 2eufB-2v55A:
24.1		 2eufB-2v55A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LYS A 105
VAL A 137
ASP A 160
ASN A 203
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 (-3.4A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.84A 2eufB-2v55A:
24.1		 2eufB-2v55A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 11 GLY A  83
VAL A  90
ALA A 103
MET A 153
TYR A 155
LEU A 205
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
 0.60A 2evaA-2v55A:
20.5		 2evaA-2v55A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
MET A 153
TYR A 155
LYS A 200
ASN A 203
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 (-2.9A)
MG  A1481 (-3.5A)
 0.69A 2fumB-2v55A:
23.0		 2fumB-2v55A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  83
GLY A  85
VAL A  90
ALA A 103
MET A 153
LYS A 200
ASN A 203
 ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 (-2.9A)
MG  A1481 (-3.5A)
 1.09A 2fumD-2v55A:
21.8		 2fumD-2v55A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 103
ILE A 127
VAL A 137
GLY A 158
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.27A 2hyyC-2v55A:
17.8		 2hyyC-2v55A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 103
ILE A 127
VAL A 137
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.19A 2hyyC-2v55A:
17.8		 2hyyC-2v55A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  90
ALA A 103
ILE A 127
VAL A 137
GLY A 159
LEU A 205
ALA A 215
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 1.21A 2hyyC-2v55A:
17.8		 2hyyC-2v55A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 LEU A 268
LEU A 272
ILE A 313
PHE A 299
LEU A 297
 None
 1.27A 2q6hA-2v55A:
undetectable		 2q6hA-2v55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 LEU A 268
LEU A 272
ILE A 313
PHE A 299
LEU A 297
 None
 1.22A 2qeiA-2v55A:
undetectable		 2qeiA-2v55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 HIS A 196
MET A 221
CYH A 259
GLY A 256
VAL A 235
 None
 1.03A 2uxpB-2v55A:
0.4		 2uxpB-2v55A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 GLY A  83
VAL A  90
ALA A 103
TYR A 155
MET A 156
GLY A 159
ALA A 215
ASP A 216
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.86A 2wgjA-2v55A:
14.7		 2wgjA-2v55A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 VAL A 101
TYR A 155
ASP A 364
SER A 361
 None
ANP  A1480 ( 4.9A)
None
None
 1.31A 2x45A-2v55A:
undetectable		 2x45A-2v55A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 VAL A  90
ALA A 103
MET A 156
GLY A 159
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.85A 2xp2A-2v55A:
19.6		 2xp2A-2v55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LYS A  80
ILE A  82
ALA A 103
LYS A 105
GLU A 124
MET A 128
TYR A 155
GLY A 159
LEU A 205
 None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
 1.06A 2y6oA-2v55A:
18.6		 2y6oA-2v55A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 10 ILE A  82
VAL A  90
ALA A 103
MET A 156
GLY A 159
LEU A 205
 None
None
ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
 0.82A 2y7jC-2v55A:
27.7		 2y7jC-2v55A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 ILE A 113
PRO A 393
VAL A  93
PHE A 397
 None
 1.26A 2ygnA-2v55A:
undetectable		 2ygnA-2v55A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ALA A 103
LYS A 105
GLU A 124
VAL A 137
MET A 156
GLY A 159
LEU A 205
ALA A 215
 ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.93A 2zvaA-2v55A:
21.2		 2zvaA-2v55A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ILE A  66
ILE A  63
LEU A  34
LEU A  31
TYR A 400
 None
 1.30A 3f78A-2v55A:
undetectable		 3f78A-2v55A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ILE A  66
ILE A  63
LEU A  34
LEU A  31
TYR A 400
 None
 1.33A 3f78B-2v55A:
undetectable		 3f78B-2v55A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 11 VAL A  90
ALA A 103
TYR A 155
GLY A 159
ASP A 160
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.58A 3g0fA-2v55A:
18.6		 3g0fA-2v55A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
LYS A 105
GLU A 124
VAL A 137
TYR A 155
LEU A 205
ALA A 215
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.84A 3g5dB-2v55A:
19.4		 3g5dB-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 PRO A 393
SER A 118
ASN A 390
 None
 0.90A 3lslG-2v55A:
undetectable		 3lslG-2v55A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 103
ILE A 127
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.13A 3mssD-2v55A:
17.6		 3mssD-2v55A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
LYS A 105
GLU A 124
VAL A 137
TYR A 155
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
 0.75A 3qlgA-2v55A:
19.2		 3qlgA-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
GLU A 124
VAL A 137
TYR A 155
GLY A 159
LEU A 205
ALA A 215
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.90A 3qlgB-2v55A:
19.5		 3qlgB-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ILE A  82
ALA A 103
VAL A 137
ASP A 160
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.85A 3ti1A-2v55A:
21.2		 3ti1A-2v55A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ILE A  82
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
 None
ANP  A1480 ( 3.8A)
None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
 0.82A 3v5wA-2v55A:
10.9		 3v5wA-2v55A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A 265
PHE A 338
PHE A 337
LEU A 312
 None
 0.89A 3v7pA-2v55A:
undetectable		 3v7pA-2v55A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 9 VAL A  90
ALA A 103
MET A 156
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.97A 4anqA-2v55A:
19.5		 4anqA-2v55A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 9 VAL A  90
ALA A 103
MET A 153
MET A 156
GLY A 159
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
None
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.88A 4ansA-2v55A:
19.5		 4ansA-2v55A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 9 VAL A  90
ALA A 103
MET A 156
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.99A 4ansA-2v55A:
19.5		 4ansA-2v55A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  90
ALA A 103
GLU A 124
ILE A 127
MET A 128
MET A 151
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
None
None
ANP  A1480 (-3.5A)
 1.31A 4bkjB-2v55A:
18.5		 4bkjB-2v55A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  90
ALA A 103
GLU A 124
MET A 128
MET A 151
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.18A 4bkjB-2v55A:
18.5		 4bkjB-2v55A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  90
ALA A 103
MET A 151
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.07A 4bkjB-2v55A:
18.5		 4bkjB-2v55A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 103
LYS A 105
GLU A 124
HIS A 196
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.12A 4c8bA-2v55A:
20.4		 4c8bA-2v55A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 LEU A 212
ASP A 216
VAL A 136
ILE A 195
 None
ANP  A1480 (-3.5A)
None
None
 0.90A 4eyrA-2v55A:
undetectable		 4eyrA-2v55A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 11 VAL A  90
ALA A 103
LYS A 105
ASP A 160
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.83A 4iaaA-2v55A:
24.3		 4iaaA-2v55A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 GLY A  83
VAL A  90
ALA A 103
LEU A 139
GLY A 159
LEU A 205
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
None
None
ANP  A1480 ( 4.7A)
 0.49A 4ifgA-2v55A:
22.4		 4ifgA-2v55A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 10 ILE A  82
ALA A 103
VAL A 137
MET A 153
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.1A)
None
ANP  A1480 ( 4.7A)
 0.66A 4ks8A-2v55A:
26.7		 4ks8A-2v55A:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 ALA A 103
LEU A 107
MET A 153
MET A 156
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.1A)
None
 0.82A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 7 ALA A 103
MET A 153
MET A 156
ASP A 160
LEU A 205
 ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.63A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 VAL A  90
ALA A 103
LEU A 107
MET A 153
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.1A)
 0.46A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 7 VAL A  90
ALA A 103
MET A 153
ASP A 160
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.73A 4l9iA-2v55A:
12.1		 4l9iA-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 8 GLY A  85
ALA A 103
LYS A 105
MET A 153
MET A 156
ASP A 160
LEU A 205
 ANP  A1480 ( 3.8A)
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
ANP  A1480 (-4.1A)
None
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.90A 4l9iB-2v55A:
28.0		 4l9iB-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 8 GLY A  85
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 160
LEU A 205
 ANP  A1480 ( 3.8A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
ANP  A1480 (-4.1A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 0.81A 4l9iB-2v55A:
28.0		 4l9iB-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
 None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
ANP  A1480 (-4.1A)
 1.25A 4l9iB-2v55A:
28.0		 4l9iB-2v55A:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 SER A 263
SER A 242
ILE A 195
GLU A 258
 None
 1.32A 4ms4A-2v55A:
undetectable		 4ms4A-2v55A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ALA A 103
GLU A 124
VAL A 137
MET A 153
TYR A 155
GLY A 159
LEU A 205
ASP A 216
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.91A 4mxyA-2v55A:
20.5		 4mxyA-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ALA A 103
GLU A 124
VAL A 137
MET A 153
TYR A 155
GLY A 159
LEU A 205
ASP A 216
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.91A 4mxzA-2v55A:
20.5		 4mxzA-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 ILE A  82
VAL A  90
ALA A 103
ASP A 160
ASN A 203
LEU A 205
 None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.0A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
 0.89A 4ogrI-2v55A:
25.0		 4ogrI-2v55A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  90
LYS A 105
VAL A 137
TYR A 155
GLY A 159
LEU A 205
ALA A 215
 None
ANP  A1480 (-3.4A)
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.90A 4otwA-2v55A:
18.0		 4otwA-2v55A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 103
LYS A 105
GLU A 124
MET A 153
TYR A 155
LEU A 205
ASP A 216
 ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.08A 4qmnA-2v55A:
26.5		 4qmnA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ILE A  82
ALA A 103
GLU A 124
TYR A 155
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.92A 4qmnA-2v55A:
26.5		 4qmnA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ILE A  82
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 0.88A 4qmnA-2v55A:
26.5		 4qmnA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ILE A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
TYR A 155
LEU A 205
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
 0.67A 4qmzA-2v55A:
26.5		 4qmzA-2v55A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 VAL A  90
ALA A 103
LYS A 105
MET A 156
GLY A 159
ASN A 203
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.83A 4twpA-2v55A:
20.7		 4twpA-2v55A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
LYS A 105
MET A 156
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.90A 4twpB-2v55A:
21.0		 4twpB-2v55A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
MET A 156
GLY A 159
ASN A 203
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.80A 4twpB-2v55A:
21.0		 4twpB-2v55A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		10 / 11 GLY A  85
VAL A  90
ALA A 103
TYR A 155
MET A 156
GLY A 159
ASN A 203
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 ( 3.8A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
None
None
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.72A 4u5jA-2v55A:
21.2		 4u5jA-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 VAL A  90
ALA A 103
TYR A 155
MET A 156
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.7A)
 0.72A 4u5jB-2v55A:
20.8		 4u5jB-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 ALA A 103
MET A 153
MET A 156
LEU A 205
 ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
ANP  A1480 ( 4.7A)
 0.45A 4wboC-2v55A:
27.8		 4wboC-2v55A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ALA A 103
GLU A 124
VAL A 137
TYR A 155
MET A 156
GLY A 159
LEU A 205
ALA A 215
 ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.85A 4xliA-2v55A:
21.5		 4xliA-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ALA A 103
LYS A 105
GLU A 124
VAL A 137
TYR A 155
MET A 156
GLY A 159
LEU A 205
 ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.7A)
 0.86A 4xliA-2v55A:
21.5		 4xliA-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ALA A 103
LYS A 105
GLU A 124
VAL A 137
TYR A 155
GLY A 159
LEU A 205
ALA A 215
 ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.82A 4xliB-2v55A:
21.4		 4xliB-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 10 VAL A  90
ALA A 103
LYS A 105
MET A 156
GLY A 159
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.01A 5aabA-2v55A:
19.6		 5aabA-2v55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 10 VAL A  90
ALA A 103
LYS A 105
MET A 156
GLY A 159
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.11A 5aacA-2v55A:
19.4		 5aacA-2v55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 ALA A 175
TYR A 178
GLY A  85
LEU A 205
 None
None
ANP  A1480 ( 3.8A)
ANP  A1480 ( 4.7A)
 0.99A 5eslA-2v55A:
undetectable		 5eslA-2v55A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A  85
LEU A 139
ASP A 216
PHE A 217
 ANP  A1480 ( 3.8A)
None
ANP  A1480 (-3.5A)
None
 0.74A 5hieB-2v55A:
7.8		 5hieB-2v55A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2v55 RHO-RELATED
GTP-BINDING PROTEIN
RHOE
(Homo
sapiens) 		5 / 11 SER B  79
GLY B  30
VAL B  29
SER B  32
ASP B  31
 GTP  B1201 ( 4.7A)
None
None
GTP  B1201 (-3.3A)
None
 1.01A 5i3cC-2v55B:
2.9		 5i3cC-2v55B:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ILE A  82
ALA A 103
LYS A 105
GLU A 124
MET A 128
TYR A 155
GLY A 159
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.9A)
None
 0.87A 5i9yA-2v55A:
19.0		 5i9yA-2v55A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ILE A  82
ALA A 103
LYS A 105
MET A 128
TYR A 155
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
None
ANP  A1480 ( 4.7A)
 0.82A 5i9yA-2v55A:
19.0		 5i9yA-2v55A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A  83
GLY A  85
LYS A 105
LEU A 107
 ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
ANP  A1480 (-3.4A)
None
 0.53A 5izfA-2v55A:
35.0		 5izfA-2v55A:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 7 GLY A  83
GLY A  85
VAL A  90
LYS A 105
LEU A 107
 ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
None
ANP  A1480 (-3.4A)
None
 0.47A 5izjA-2v55A:
27.0		 5izjA-2v55A:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A  83
GLY A  85
VAL A  90
LYS A 105
 ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
None
ANP  A1480 (-3.4A)
 0.41A 5j5xA-2v55A:
25.0		 5j5xA-2v55A:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASP A 160
LEU A 205
ALA A 215
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.65A 5l2iA-2v55A:
7.5		 5l2iA-2v55A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASP A 160
LEU A 205
ALA A 215
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.92A 5l2tA-2v55A:
7.5		 5l2tA-2v55A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ILE A  82
GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASP A 160
LEU A 205
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
 1.21A 5l2tA-2v55A:
7.5		 5l2tA-2v55A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 11 GLY A  83
VAL A  90
ALA A 103
VAL A 137
TYR A 155
LEU A 205
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
 0.54A 5lvnA-2v55A:
31.7		 5lvnA-2v55A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  83
VAL A  90
ALA A 103
MET A 153
MET A 156
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
 0.64A 5lw1B-2v55A:
22.6		 5lw1B-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ILE A  82
GLY A  83
VAL A  90
ALA A 103
MET A 156
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
None
 0.67A 5lw1B-2v55A:
22.6		 5lw1B-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 GLY A  83
VAL A  90
ALA A 103
MET A 153
MET A 156
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
 0.65A 5lw1E-2v55A:
22.6		 5lw1E-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  83
VAL A  90
ALA A 103
MET A 153
MET A 156
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
 0.52A 5lw1H-2v55A:
22.7		 5lw1H-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 ILE A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
GLY A 159
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
None
 0.58A 5mafA-2v55A:
26.9		 5mafA-2v55A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2v55 RHO-RELATED
GTP-BINDING PROTEIN
RHOE
(Homo
sapiens) 		5 / 12 VAL B 198
ILE B  26
LEU B  99
VAL B 133
ILE B 189
 None
 0.90A 5mueA-2v55B:
undetectable		 5mueA-2v55B:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 10 VAL A  90
ALA A 103
VAL A 137
MET A 153
TYR A 155
LEU A 205
PHE A 368
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-4.5A)
 0.72A 5n3hA-2v55A:
35.2		 5n3hA-2v55A:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  92
ALA A 103
GLU A 124
MET A 128
GLY A 158
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
None
None
ANP  A1480 ( 4.7A)
 1.13A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  92
ALA A 103
GLU A 124
MET A 128
GLY A 159
ASN A 163
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
None
None
None
ANP  A1480 ( 4.7A)
 1.05A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  92
ALA A 103
GLU A 124
VAL A 137
GLY A 158
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
ANP  A1480 ( 4.7A)
 1.02A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  92
ALA A 103
GLU A 124
VAL A 137
GLY A 159
ASN A 163
LEU A 205
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 (-4.7A)
None
None
ANP  A1480 ( 4.7A)
 1.00A 5te0A-2v55A:
23.8		 5te0A-2v55A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ILE A  82
GLY A  83
ALA A 103
GLU A 124
TYR A 155
ASP A 216
 None
ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.9A)
None
ANP  A1480 ( 4.9A)
ANP  A1480 (-3.5A)
 0.92A 5vc3A-2v55A:
22.3		 5vc3A-2v55A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ILE A  82
GLY A  83
GLU A 124
TYR A 155
GLY A 159
ASP A 216
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 4.9A)
None
ANP  A1480 (-3.5A)
 0.82A 5vc3A-2v55A:
22.3		 5vc3A-2v55A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
MET A 156
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.7A)
 0.86A 6bsdA-2v55A:
17.9		 6bsdA-2v55A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 ALA A 180
THR A 179
TYR A 178
GLN A 342
 None
 0.72A 6cduA-2v55A:
undetectable
6cduE-2v55A:
undetectable		 6cduA-2v55A:
20.82
6cduE-2v55A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 GLN A 342
ALA A 180
THR A 179
TYR A 178
 None
 0.85A 6cduD-2v55A:
undetectable
6cduE-2v55A:
undetectable		 6cduD-2v55A:
20.82
6cduE-2v55A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLN A 342
ALA A 180
THR A 179
TYR A 178
 None
 0.70A 6cduH-2v55A:
undetectable
6cduI-2v55A:
undetectable		 6cduH-2v55A:
20.82
6cduI-2v55A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 ARG A  67
ARG A  70
ASP A  35
 None
 0.96A 6d8pA-2v55A:
undetectable		 6d8pA-2v55A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 ASP A  32
ARG A  70
GLN A 391
TYR A  39
 None
 1.34A 6g31G-2v55A:
undetectable		 6g31G-2v55A:
12.61