SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 2v5e GDNF FAMILY RECEPTOR
ALPHA-1
GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR
(Homo
sapiens;
Rattus
norvegicus) 		5 / 11 SER A 172
ARG A 171
SER B 112
LEU B 111
LEU B  63
 None
 1.49A 1hwkC-2v5eA:
undetectable		 1hwkC-2v5eA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2v5e GDNF FAMILY RECEPTOR
ALPHA-1
(Rattus
norvegicus) 		4 / 7 ILE A 293
ARG A 225
PHE A 213
ILE A 342
 None
 1.22A 2qb4A-2v5eA:
undetectable		 2qb4A-2v5eA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2v5e GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR
(Homo
sapiens) 		4 / 8 ILE B 134
GLY B 132
LEU B  43
PHE B 107
 None
 0.92A 2vctC-2v5eB:
undetectable		 2vctC-2v5eB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2v5e GDNF FAMILY RECEPTOR
ALPHA-1
GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR
(Homo
sapiens;
Rattus
norvegicus) 		5 / 9 ILE A 229
TYR A 174
ILE A 293
LEU A 212
TYR B 120
 None
 1.42A 3f78A-2v5eA:
undetectable		 3f78A-2v5eA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 2v5e GDNF FAMILY RECEPTOR
ALPHA-1
GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR
(Homo
sapiens;
Rattus
norvegicus) 		5 / 9 ILE A 229
TYR A 174
ILE A 293
LEU A 212
TYR B 120
 None
 1.41A 3f78B-2v5eA:
undetectable		 3f78B-2v5eA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2v5e GDNF FAMILY RECEPTOR
ALPHA-1
(Rattus
norvegicus) 		3 / 3 ARG A 190
HIS A 193
ARG A 197
 SCR  A1350 (-4.3A)
None
SCR  A1350 ( 3.1A)
 1.14A 6dwdD-2v5eA:
undetectable		 6dwdD-2v5eA:
15.53