SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2v5g YSCU
(Yersinia
enterocolitica) 		5 / 12 VAL A 283
ILE A 271
GLU A 227
GLU A 329
VAL A 261
 None
 1.09A 4a97B-2v5gA:
undetectable
4a97C-2v5gA:
undetectable		 4a97B-2v5gA:
19.05
4a97C-2v5gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2v5g YSCU
(Yersinia
enterocolitica) 		3 / 3 PHE A 285
ASP A 323
ARG A 256
 None
 0.59A 4eahF-2v5gA:
undetectable		 4eahF-2v5gA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2v5g YSCU
(Yersinia
enterocolitica) 		3 / 3 PHE A 285
ASP A 323
ARG A 256
 None
 0.60A 4eahG-2v5gA:
undetectable		 4eahG-2v5gA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2v5g YSCU
(Yersinia
enterocolitica) 		4 / 8 TYR A 287
ILE A 298
VAL A 254
ILE A 306
 None
 0.93A 5mzrE-2v5gA:
undetectable		 5mzrE-2v5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2v5g YSCU
(Yersinia
enterocolitica) 		5 / 9 ARG A 296
ILE A 271
GLY A 270
LEU A 341
LEU A 307
 None
 1.01A 5o96A-2v5gA:
undetectable
5o96B-2v5gA:
undetectable		 5o96A-2v5gA:
20.73
5o96B-2v5gA:
20.73