SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 6 PHE A1637
VAL A1587
VAL A1609
SER A1611
 None
 0.96A 1e7aB-2v5nA:
undetectable		 1e7aB-2v5nA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A1527
GLU A1647
GLN A1648
ASN A1520
 None
 1.40A 1jqdA-2v5nA:
undetectable		 1jqdA-2v5nA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		3 / 3 ASN A1743
LEU A1663
PHE A1787
 None
 0.77A 4dajB-2v5nA:
undetectable		 4dajB-2v5nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A1764
ASN A1693
ILE A1667
GLY A1729
ALA A1728
 None
 1.05A 4e1gA-2v5nA:
undetectable		 4e1gA-2v5nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 8 VAL A1786
LEU A1761
TYR A1741
ILE A1732
 None
 0.95A 4ma7A-2v5nA:
undetectable		 4ma7A-2v5nA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 11 THR A1539
ALA A1540
GLY A1564
ALA A1565
SER A1608
 None
 0.95A 4qvlK-2v5nA:
undetectable
4qvlL-2v5nA:
undetectable		 4qvlK-2v5nA:
20.26
4qvlL-2v5nA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 11 THR A1539
ALA A1540
GLY A1564
ALA A1565
SER A1608
 None
 0.95A 4qvlY-2v5nA:
undetectable
4qvlZ-2v5nA:
undetectable		 4qvlY-2v5nA:
20.26
4qvlZ-2v5nA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 10 THR A1539
ALA A1540
GLY A1564
ALA A1565
SER A1608
 None
 0.96A 4qvmY-2v5nA:
undetectable
4qvmZ-2v5nA:
undetectable		 4qvmY-2v5nA:
20.77
4qvmZ-2v5nA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 11 THR A1539
ALA A1540
GLY A1564
ALA A1565
SER A1608
 None
 0.93A 4qw1K-2v5nA:
undetectable
4qw1L-2v5nA:
undetectable		 4qw1K-2v5nA:
20.06
4qw1L-2v5nA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 11 THR A1539
ALA A1540
GLY A1564
ALA A1565
SER A1608
 None
 0.96A 5bxnK-2v5nA:
undetectable
5bxnL-2v5nA:
undetectable		 5bxnK-2v5nA:
20.26
5bxnL-2v5nA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 11 THR A1539
ALA A1540
GLY A1564
ALA A1565
SER A1608
 None
 0.94A 5bxnY-2v5nA:
undetectable
5bxnZ-2v5nA:
undetectable		 5bxnY-2v5nA:
20.26
5bxnZ-2v5nA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		3 / 3 ASN A1743
LEU A1663
PHE A1787
 None
 0.68A 5dsgA-2v5nA:
undetectable		 5dsgA-2v5nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 5 TYR A1592
GLY A1564
GLY A1619
LEU A1532
 None
 0.91A 5jlcA-2v5nA:
undetectable		 5jlcA-2v5nA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 11 GLY A1564
MET A1550
VAL A1574
PHE A1638
GLY A1575
 None
 1.46A 5yjsA-2v5nA:
undetectable		 5yjsA-2v5nA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 6 PRO A1597
ILE A1572
GLY A1595
TYR A1606
 None
 1.14A 6gqiA-2v5nA:
undetectable		 6gqiA-2v5nA:
17.98