SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 7 ILE A1918
ARG A1615
ARG A1669
PHE A1905
 None
 0.91A 2q6hA-2v5oA:
undetectable		 2q6hA-2v5oA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 11 GLY A1867
GLY A1890
LEU A1858
SER A1859
LEU A1857
 None
 0.92A 2qmmA-2v5oA:
undetectable
2qmmB-2v5oA:
undetectable		 2qmmA-2v5oA:
15.76
2qmmB-2v5oA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A2028
LEU A2005
TRP A2015
ILE A2026
 None
 1.15A 2rlfB-2v5oA:
undetectable
2rlfC-2v5oA:
undetectable		 2rlfB-2v5oA:
5.57
2rlfC-2v5oA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		4 / 8 THR A1983
VAL A1883
VAL A1838
LEU A1820
 None
 0.80A 2zujA-2v5oA:
undetectable		 2zujA-2v5oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A2123
LEU A2094
LEU A2028
SER A2010
SER A2118
 None
 1.17A 4q0dC-2v5oA:
undetectable		 4q0dC-2v5oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A2123
LEU A2094
LEU A2028
SER A2010
SER A2118
 None
 1.17A 4q0dD-2v5oA:
undetectable		 4q0dD-2v5oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A2067
ALA A2124
PHE A1996
 None
 0.92A 4w5nA-2v5oA:
undetectable		 4w5nA-2v5oA:
21.86