SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
4 / 8 THR A1983
VAL A1883
VAL A1838
LEU A1820
None
0.77A 2zujA-2v5pA:
undetectable
2zujA-2v5pA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
4 / 8 GLY A1719
THR A1748
PRO A1749
ILE A1722
None
None
NAG  A2992 (-3.7A)
None
0.68A 3el0A-2v5pA:
undetectable
3el0A-2v5pA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
5 / 12 GLY A1564
GLY A1534
GLY A1537
SER A1531
GLU A1555
None
1.10A 3kkzB-2v5pA:
undetectable
3kkzB-2v5pA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
3 / 3 SER A1865
GLY A1890
SER A1951
None
0.68A 3loqA-2v5pA:
undetectable
3loqA-2v5pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
3 / 3 ASP A1594
ARG A1580
LYS A1593
None
1.03A 3wipG-2v5pA:
undetectable
3wipG-2v5pA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
4 / 6 ILE A1552
LEU A1590
PHE A1612
ARG A1623
None
1.06A 5b1aN-2v5pA:
undetectable
5b1aW-2v5pA:
undetectable
5b1aN-2v5pA:
20.65
5b1aW-2v5pA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
4 / 6 TYR A1834
ILE A1953
VAL A1968
PRO A1966
None
0.91A 5cu6A-2v5pA:
undetectable
5cu6A-2v5pA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo
sapiens)
4 / 7 VAL A1986
THR A1983
LEU A1874
VAL A1838
None
0.98A 5e4dA-2v5pA:
undetectable
5e4dB-2v5pA:
undetectable
5e4dA-2v5pA:
17.31
5e4dB-2v5pA:
17.31