SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		3 / 3 TRP A 110
ALA A 126
VAL A 248
 None
 0.83A 1c4dC-2v5yA:
undetectable
1c4dD-2v5yA:
undetectable		 1c4dC-2v5yA:
3.02
1c4dD-2v5yA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		4 / 6 LEU A 125
TRP A 110
PHE A  79
VAL A 155
 None
 1.29A 1ibgH-2v5yA:
6.2		 1ibgH-2v5yA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 12 ILE A 171
PHE A 168
LEU A 169
LEU A 198
PHE A 221
 None
 0.96A 1og5B-2v5yA:
undetectable		 1og5B-2v5yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		3 / 3 LYS A 232
GLY A 291
PRO A 292
 None
 0.99A 2hreB-2v5yA:
undetectable		 2hreB-2v5yA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 12 HIS A  75
VAL A 137
PHE A 139
VAL A  98
LEU A 125
 None
 1.16A 2pouA-2v5yA:
undetectable		 2pouA-2v5yA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 12 HIS A  75
VAL A 137
PHE A 139
VAL A  98
LEU A 125
 None
 1.15A 3czvA-2v5yA:
undetectable
3czvB-2v5yA:
undetectable		 3czvA-2v5yA:
18.58
3czvB-2v5yA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 10 PHE A  79
GLY A 246
GLY A 247
THR A 165
GLU A 245
 None
 1.49A 3fw1A-2v5yA:
undetectable		 3fw1A-2v5yA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 12 HIS A  75
VAL A 137
PHE A 139
VAL A  98
LEU A 125
 None
 1.18A 3hkuA-2v5yA:
undetectable		 3hkuA-2v5yA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 11 HIS A  75
VAL A 137
PHE A 139
VAL A  98
LEU A 125
 None
 1.20A 3hs4A-2v5yA:
undetectable		 3hs4A-2v5yA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 12 ALA A 254
ALA A 182
VAL A 227
ASN A 226
PRO A 209
 None
 1.08A 3jb3A-2v5yA:
undetectable		 3jb3A-2v5yA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 11 HIS A  75
VAL A 137
PHE A 139
VAL A  98
LEU A 125
 None
 1.15A 3ml5A-2v5yA:
undetectable		 3ml5A-2v5yA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		4 / 6 GLN A 515
TYR A 539
GLN A 558
SER A 513
 None
 0.77A 3peoG-2v5yA:
undetectable		 3peoG-2v5yA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		5 / 11 HIS A  75
VAL A 137
PHE A 139
VAL A  98
LEU A 125
 None
 1.17A 3v2jA-2v5yA:
undetectable		 3v2jA-2v5yA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		4 / 6 PHE A  26
ALA A  62
GLY A  92
PRO A  91
 None
 0.92A 4dubA-2v5yA:
undetectable		 4dubA-2v5yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		4 / 6 PHE A  26
ALA A  62
GLY A  92
PRO A  91
 None
 0.92A 4dubB-2v5yA:
undetectable		 4dubB-2v5yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens) 		4 / 8 TRP A  28
PHE A  48
GLU A  29
THR A 117
 None
None
NAG  A1572 (-4.0A)
None
 1.26A 5hqaA-2v5yA:
3.0		 5hqaA-2v5yA:
22.39