SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		5 / 9 VAL A  27
GLY A  28
ASP A  53
ALA A  98
ILE A 119
 None
 0.44A 1cetA-2v65A:
38.5		 1cetA-2v65A:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		5 / 9 VAL A  27
GLY A  28
ASP A  53
TYR A  85
ALA A  98
 None
 0.58A 1cetA-2v65A:
38.5		 1cetA-2v65A:
33.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		4 / 8 THR A 273
GLY A 164
THR A 165
VAL A 302
 None
 0.58A 2a1hA-2v65A:
undetectable
2a1hB-2v65A:
undetectable		 2a1hA-2v65A:
22.53
2a1hB-2v65A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		4 / 8 VAL A 302
THR A 273
GLY A 164
THR A 165
 None
 0.55A 2a1hA-2v65A:
undetectable
2a1hB-2v65A:
undetectable		 2a1hA-2v65A:
22.53
2a1hB-2v65A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		4 / 8 THR A  97
VAL A 138
ASN A 166
ALA A 255
 None
 0.94A 2ij7C-2v65A:
undetectable		 2ij7C-2v65A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		5 / 10 THR A  97
VAL A 138
ASN A 166
ALA A 255
SER A  39
 None
 1.30A 2ij7D-2v65A:
0.0		 2ij7D-2v65A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		5 / 10 THR A  97
VAL A 138
ASN A 166
ALA A 255
SER A  39
 None
 1.27A 2ij7F-2v65A:
0.0		 2ij7F-2v65A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		4 / 8 GLU A 194
SER A 318
VAL A 232
HIS A 229
 None
 1.24A 3b9lA-2v65A:
undetectable		 3b9lA-2v65A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		4 / 8 GLN A 314
VAL A 200
VAL A 275
VAL A 281
 None
 0.75A 3fi0Q-2v65A:
undetectable		 3fi0Q-2v65A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		5 / 12 VAL A 281
MET A 305
ILE A 191
HIS A 229
VAL A 233
 None
 1.34A 3g8iA-2v65A:
0.0		 3g8iA-2v65A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		5 / 12 LEU A 210
LEU A 182
VAL A 209
GLY A 209
ALA A 209
 None
 1.10A 3rr3C-2v65A:
undetectable		 3rr3C-2v65A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		5 / 12 LEU A 210
LEU A 182
VAL A 209
GLY A 209
ALA A 209
 None
 1.10A 3rr3D-2v65A:
undetectable		 3rr3D-2v65A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		4 / 8 LEU A  45
ILE A 262
ASN A 295
GLY A 294
 None
 0.81A 3wxoA-2v65A:
undetectable		 3wxoA-2v65A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		3 / 3 LEU A   7
LYS A   4
THR A   3
 None
 0.58A 4lj0A-2v65A:
undetectable		 4lj0A-2v65A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		3 / 3 LEU A  73
LYS A  74
THR A  75
 None
 0.39A 4lj0A-2v65A:
undetectable		 4lj0A-2v65A:
10.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 2v65 L-LACTATE
DEHYDROGENASE A
CHAIN
(Champsocephalus
gunnari) 		7 / 9 ASP A  53
VAL A  54
TYR A  85
ALA A  98
ARG A 115
ILE A 119
ILE A 123
 None
 0.43A 4oknB-2v65A:
49.6		 4oknB-2v65A:
71.69