SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 9 VAL A  27
GLY A  28
ASP A  53
ALA A  98
ILE A 119
GLU A 122
None
0.67A 1cetA-2v6bA:
34.7
1cetA-2v6bA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 5 SER A  34
THR A  35
PHE A  31
GLU A  62
None
1.27A 1icrA-2v6bA:
undetectable
1icrB-2v6bA:
undetectable
1icrA-2v6bA:
23.17
1icrB-2v6bA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 5 GLU A  62
SER A  34
THR A  35
PHE A  31
None
1.24A 1icrA-2v6bA:
undetectable
1icrB-2v6bA:
undetectable
1icrA-2v6bA:
23.17
1icrB-2v6bA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 5 SER A  34
THR A  35
PHE A  31
GLU A  62
None
1.28A 1icvC-2v6bA:
undetectable
1icvD-2v6bA:
undetectable
1icvC-2v6bA:
23.17
1icvD-2v6bA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 5 GLU A  62
SER A  34
THR A  35
PHE A  31
None
1.30A 1icvC-2v6bA:
undetectable
1icvD-2v6bA:
undetectable
1icvC-2v6bA:
23.17
1icvD-2v6bA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 8 LEU A 269
VAL A 293
VAL A  93
VAL A 134
None
0.99A 1iwiA-2v6bA:
undetectable
1iwiA-2v6bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 5 GLU A  62
SER A  34
THR A  35
PHE A  31
None
1.27A 1kqbA-2v6bA:
undetectable
1kqbB-2v6bA:
undetectable
1kqbA-2v6bA:
23.78
1kqbB-2v6bA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 GLY A 164
SER A 163
LEU A 254
ILE A 257
LEU A 269
None
1.21A 1kyvA-2v6bA:
4.6
1kyvE-2v6bA:
4.5
1kyvA-2v6bA:
22.40
1kyvE-2v6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 269
GLY A 164
SER A 163
LEU A 254
ILE A 257
None
1.23A 1kyvB-2v6bA:
2.6
1kyvC-2v6bA:
2.5
1kyvB-2v6bA:
22.40
1kyvC-2v6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 269
GLY A 164
SER A 163
LEU A 254
ILE A 257
None
1.24A 1kyvC-2v6bA:
2.6
1kyvD-2v6bA:
4.4
1kyvC-2v6bA:
22.40
1kyvD-2v6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 269
GLY A 164
SER A 163
LEU A 254
ILE A 257
None
1.25A 1kyvD-2v6bA:
5.5
1kyvE-2v6bA:
5.6
1kyvD-2v6bA:
22.40
1kyvE-2v6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 8 LEU A 269
VAL A 293
VAL A  93
VAL A 134
None
0.92A 1t86A-2v6bA:
undetectable
1t86A-2v6bA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
3 / 3 GLU A 259
THR A 258
LEU A  49
None
0.71A 1v8bC-2v6bA:
6.2
1v8bC-2v6bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
0.93A 2hs2A-2v6bA:
undetectable
2hs2A-2v6bA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  26
VAL A  93
ILE A  95
None
1.28A 2ienA-2v6bA:
undetectable
2ienA-2v6bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
1.00A 2pynA-2v6bA:
undetectable
2pynA-2v6bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
0.99A 2pynB-2v6bA:
undetectable
2pynB-2v6bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  26
VAL A  93
ILE A  95
None
1.21A 2q63A-2v6bA:
undetectable
2q63A-2v6bA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  26
VAL A  93
ILE A  95
None
1.27A 2q64B-2v6bA:
undetectable
2q64B-2v6bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
0.94A 2qakB-2v6bA:
undetectable
2qakB-2v6bA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 7 VAL A  52
GLY A  28
ALA A  98
LEU A  96
None
0.87A 2wekB-2v6bA:
5.9
2wekB-2v6bA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 7 ASP A 229
SER A 198
GLU A 194
ASP A 143
None
1.33A 3bc9A-2v6bA:
undetectable
3bc9A-2v6bA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  26
VAL A  93
ILE A  95
None
1.22A 3bvbA-2v6bA:
undetectable
3bvbA-2v6bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
0.92A 3cyxA-2v6bA:
undetectable
3cyxA-2v6bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 254
ALA A 170
ALA A 267
VAL A 293
ILE A 250
None
1.09A 3czhB-2v6bA:
undetectable
3czhB-2v6bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 GLY A  33
THR A  97
ASP A  65
ILE A  66
LEU A  51
None
1.37A 3iv6C-2v6bA:
5.2
3iv6C-2v6bA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  26
VAL A  93
ILE A  95
None
1.22A 3k4vB-2v6bA:
undetectable
3k4vB-2v6bA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
1.03A 3nu3A-2v6bA:
undetectable
3nu3A-2v6bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  26
VAL A  93
ILE A  95
None
1.28A 3nu5A-2v6bA:
undetectable
3nu5A-2v6bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 10 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
1.09A 3nu6B-2v6bA:
undetectable
3nu6B-2v6bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
0.98A 3oxxC-2v6bA:
undetectable
3oxxC-2v6bA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  93
ILE A  95
None
1.01A 3pwrA-2v6bA:
undetectable
3pwrA-2v6bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 8 THR A  97
LEU A 254
GLY A 251
THR A  35
None
0.88A 4c9nA-2v6bA:
undetectable
4c9nA-2v6bA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 8 LEU A 269
VAL A 293
VAL A  93
VAL A 134
None
0.93A 4l4bA-2v6bA:
undetectable
4l4bA-2v6bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 GLY A 251
ALA A  39
GLU A 259
LEU A  51
ARG A  58
None
1.24A 4retA-2v6bA:
undetectable
4retA-2v6bA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 GLY A 251
ALA A  39
GLU A 259
LEU A  51
ARG A  58
None
1.24A 4retC-2v6bA:
undetectable
4retC-2v6bA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 7 ALA A 206
ILE A 228
LEU A 201
PHE A 172
None
1.13A 4uymB-2v6bA:
undetectable
4uymB-2v6bA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 5 LEU A 287
GLU A 199
LEU A 307
HIS A 304
None
1.37A 4xi3B-2v6bA:
undetectable
4xi3B-2v6bA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 9 ASP A 197
LEU A 113
VAL A 142
SER A 139
None
0.93A 6c2mD-2v6bA:
undetectable
6c2mD-2v6bA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
4 / 8 LEU A 269
VAL A 293
VAL A  93
VAL A 134
None
0.94A 6cp4A-2v6bA:
undetectable
6cp4A-2v6bA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 LEU A 136
ALA A  36
LEU A  51
VAL A  93
ILE A  95
None
1.05A 6dgxB-2v6bA:
undetectable
6dgxB-2v6bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
6 / 12 LEU A 136
GLY A 251
ALA A  36
VAL A  26
VAL A  93
ILE A  95
None
1.33A 6dilB-2v6bA:
undetectable
6dilB-2v6bA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans)
5 / 12 VAL A 166
ILE A 257
SER A 286
VAL A 137
ILE A 161
None
1.35A 6gsdA-2v6bA:
7.6
6gsdA-2v6bA:
14.14