SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FB7_A_ROCA100_1 (HIV-1 PROTEASE)	2v6c	PROLIFERATION-ASSOCI ATED PROTEIN 2G4 (Mus musculus)	5 / 12	ASP A 53 GLY A 52 VAL A 121 PRO A 277 ILE A 74	None	1.00A	1fb7A-2v6cA: undetectable	1fb7A-2v6cA: 13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVS_B_MK1B902_3 (POL POLYPROTEIN)	2v6c	PROLIFERATION-ASSOCI ATED PROTEIN 2G4 (Mus musculus)	5 / 12	ARG A 33 GLY A 52 GLY A 111 VAL A 112 ILE A 108	None	1.12A	2avsB-2v6cA: undetectable	2avsB-2v6cA: 13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_B_NOVB2000_1 (DNA GYRASE SUBUNIT B)	2v6c	PROLIFERATION-ASSOCI ATED PROTEIN 2G4 (Mus musculus)	5 / 12	SER A 47 ILE A 80 GLN A 318 ILE A 108 SER A 39	None	1.40A	4uroB-2v6cA: undetectable	4uroB-2v6cA: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NUJ_A_Z80A201_1 (BETA-LACTOGLOBULIN)	2v6c	PROLIFERATION-ASSOCI ATED PROTEIN 2G4 (Mus musculus)	4 / 8	VAL A 323 PHE A 218 LEU A 325 VAL A 166	None	0.79A	5nujA-2v6cA: undetectable	5nujA-2v6cA: 12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_F_CVIF301_1 (REGULATORY PROTEIN TETR)	2v6c	PROLIFERATION-ASSOCI ATED PROTEIN 2G4 (Mus musculus)	4 / 8	GLN A 242 TYR A 309 VAL A 45 ASP A 53	None	1.09A	5vlmF-2v6cA: undetectable	5vlmF-2v6cA: 17.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FB7_A_ROCA100_1","HIV-1 PROTEASE","2v6c","PROLIFERATION-ASSOCIATED PROTEIN 2G4","Mus musculus",5,"ASP A  53;GLY A  52;VAL A 121;PRO A 277;ILE A  74","None","1.00A","1fb7A-2v6cA:undetectable","1fb7A-2v6cA:13.03"],["2AVS_B_MK1B902_3","POL POLYPROTEIN","2v6c","PROLIFERATION-ASSOCIATED PROTEIN 2G4","Mus musculus",5,"ARG A  33;GLY A  52;GLY A 111;VAL A 112;ILE A 108","None","1.12A","2avsB-2v6cA:undetectable","2avsB-2v6cA:13.03"],["4URO_B_NOVB2000_1","DNA GYRASE SUBUNIT B","2v6c","PROLIFERATION-ASSOCIATED PROTEIN 2G4","Mus musculus",5,"SER A  47;ILE A  80;GLN A 318;ILE A 108;SER A  39","None","1.40A","4uroB-2v6cA:undetectable","4uroB-2v6cA:21.01"],["5NUJ_A_Z80A201_1","BETA-LACTOGLOBULIN","2v6c","PROLIFERATION-ASSOCIATED PROTEIN 2G4","Mus musculus",4,"VAL A 323;PHE A 218;LEU A 325;VAL A 166","None","0.79A","5nujA-2v6cA:undetectable","5nujA-2v6cA:12.93"],["5VLM_F_CVIF301_1","REGULATORY PROTEIN TETR","2v6c","PROLIFERATION-ASSOCIATED PROTEIN 2G4","Mus musculus",4,"GLN A 242;TYR A 309;VAL A  45;ASP A  53","None","1.09A","5vlmF-2v6cA:undetectable","5vlmF-2v6cA:17.56"]]