SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		3 / 3 TRP A 437
ARG A 396
THR A 436
 None
 0.93A 1df7A-2v6eA:
undetectable		 1df7A-2v6eA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		5 / 10 PHE A 428
TYR A 238
GLY A 273
ALA A 270
ALA A 269
 None
 1.04A 2ej3B-2v6eA:
undetectable		 2ej3B-2v6eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		3 / 3 ASP A 407
PHE A 410
LEU A 414
 None
 0.67A 2zi9A-2v6eA:
undetectable		 2zi9A-2v6eA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		4 / 7 ILE A 279
LEU A 268
ARG A 310
THR A 294
 None
 1.00A 3ag2N-2v6eA:
undetectable
3ag2W-2v6eA:
undetectable		 3ag2N-2v6eA:
19.87
3ag2W-2v6eA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		4 / 8 PRO A 263
ALA A 267
ALA A 270
ILE A 245
 None
 0.69A 3dtuC-2v6eA:
undetectable
3dtuD-2v6eA:
undetectable		 3dtuC-2v6eA:
21.52
3dtuD-2v6eA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		3 / 3 TYR A 386
ARG A 274
SER A 272
 None
 0.96A 4dr2I-2v6eA:
undetectable
4dr2J-2v6eA:
undetectable		 4dr2I-2v6eA:
11.90
4dr2J-2v6eA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		3 / 3 TYR A 386
ARG A 274
SER A 272
 None
 0.92A 4lf7I-2v6eA:
undetectable
4lf7J-2v6eA:
undetectable		 4lf7I-2v6eA:
11.90
4lf7J-2v6eA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		3 / 3 TYR A 386
ARG A 274
SER A 272
 None
 0.92A 4lf8I-2v6eA:
undetectable
4lf8J-2v6eA:
undetectable		 4lf8I-2v6eA:
11.90
4lf8J-2v6eA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		4 / 6 MET A 276
ILE A 233
ILE A 531
VAL A 231
 None
 0.69A 4olmA-2v6eA:
undetectable		 4olmA-2v6eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		3 / 5 GLY A 307
GLY A 297
GLU A 284
 None
 0.39A 4z2eA-2v6eA:
undetectable
4z2eD-2v6eA:
undetectable		 4z2eA-2v6eA:
21.28
4z2eD-2v6eA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		4 / 7 PHE A 428
ARG A 377
ILE A 233
TYR A 238
 None
 1.36A 5a06B-2v6eA:
undetectable		 5a06B-2v6eA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		4 / 6 ILE A 279
LEU A 268
ARG A 310
THR A 294
 None
 1.04A 5b1aN-2v6eA:
undetectable
5b1aW-2v6eA:
undetectable		 5b1aN-2v6eA:
19.87
5b1aW-2v6eA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		5 / 12 GLN A 427
VAL A 231
PHE A 428
LEU A 372
VAL A 368
 None
 1.27A 5i8fA-2v6eA:
undetectable		 5i8fA-2v6eA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		3 / 3 VAL A 378
LEU A 328
MET A 261
 None
 0.86A 5ikrA-2v6eA:
undetectable		 5ikrA-2v6eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		4 / 4 ASP A 381
ILE A 531
PRO A 529
LEU A 372
 None
 1.36A 6mkeB-2v6eA:
undetectable		 6mkeB-2v6eA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2v6e PROTELEMORASE
(Klebsiella
phage
phiKO2) 		4 / 4 ASP A 381
ILE A 531
PRO A 529
LEU A 372
 None
 1.39A 6mkeA-2v6eA:
undetectable		 6mkeA-2v6eA:
10.63