SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 8 THR A  51
PRO A  52
GLY A  53
LEU A  42
 None
 0.51A 1h4oG-2v6gA:
2.1		 1h4oG-2v6gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 7 SER A 251
ASP A 249
SER A 277
GLN A 143
 None
None
None
NAP  A1390 (-3.9A)
 1.14A 2cmlA-2v6gA:
undetectable		 2cmlA-2v6gA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		5 / 12 CYH A 250
PHE A 375
SER A 371
GLY A 239
LEU A 310
 None
 1.23A 2lbdA-2v6gA:
undetectable		 2lbdA-2v6gA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 4 ALA A 384
VAL A 388
PHE A 209
THR A 331
 None
 1.32A 2pkkA-2v6gA:
5.1		 2pkkA-2v6gA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		6 / 12 GLY A 208
ALA A 253
ASP A 252
VAL A 276
GLY A 204
ILE A  38
 None
None
NA  A1392 (-3.3A)
None
NAP  A1390 (-4.5A)
NAP  A1390 ( 4.6A)
 1.14A 2rkgA-2v6gA:
undetectable		 2rkgA-2v6gA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 7 THR A  51
PRO A  52
GLY A  53
LEU A  42
 None
 0.55A 2vl2B-2v6gA:
undetectable		 2vl2B-2v6gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		6 / 12 LEU A 127
ILE A  75
LEU A  95
VAL A  98
VAL A 130
LEU A  92
 None
 1.48A 3gwxB-2v6gA:
undetectable		 3gwxB-2v6gA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		5 / 12 ILE A  37
GLY A  36
GLY A  39
ALA A  43
ALA A  62
 NAP  A1390 (-4.0A)
NAP  A1390 (-3.1A)
None
None
NAP  A1390 (-3.6A)
 1.10A 3jayA-2v6gA:
undetectable		 3jayA-2v6gA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		5 / 6 GLY A  53
GLY A  54
SER A  27
LEU A  46
HIS A 100
 None
 1.19A 3o9mB-2v6gA:
2.2		 3o9mB-2v6gA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		6 / 12 GLY A 208
ALA A 253
ASP A 252
VAL A 276
GLY A 204
ILE A  38
 None
None
NA  A1392 (-3.3A)
None
NAP  A1390 (-4.5A)
NAP  A1390 ( 4.6A)
 1.18A 3s54B-2v6gA:
undetectable		 3s54B-2v6gA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 4 TRP A 284
LEU A 221
LEU A 310
THR A 238
 None
 1.49A 4bboD-2v6gA:
undetectable		 4bboD-2v6gA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 8 ILE A  37
TRP A 284
GLY A 204
ASN A 278
 NAP  A1390 (-4.0A)
None
NAP  A1390 (-4.5A)
None
 0.92A 4fgjA-2v6gA:
7.3
4fgjB-2v6gA:
7.3		 4fgjA-2v6gA:
22.51
4fgjB-2v6gA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		6 / 12 GLY A 208
ALA A 253
ASP A 252
GLY A 204
VAL A 104
ILE A  38
 None
None
NA  A1392 (-3.3A)
NAP  A1390 (-4.5A)
None
NAP  A1390 ( 4.6A)
 1.50A 4jecA-2v6gA:
undetectable		 4jecA-2v6gA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		5 / 12 VAL A  58
GLY A  39
ILE A  75
GLY A  33
ILE A  31
 None
None
None
NAP  A1390 (-3.1A)
None
 1.01A 4q5mA-2v6gA:
undetectable		 4q5mA-2v6gA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 7 THR A 220
LEU A 221
LEU A 217
THR A 238
 None
 0.91A 4z90A-2v6gA:
undetectable
4z90B-2v6gA:
undetectable
4z90C-2v6gA:
undetectable
4z90D-2v6gA:
undetectable
4z90E-2v6gA:
undetectable		 4z90A-2v6gA:
21.37
4z90B-2v6gA:
21.37
4z90C-2v6gA:
21.37
4z90D-2v6gA:
21.37
4z90E-2v6gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		6 / 12 GLY A 208
ALA A 253
ASP A 252
VAL A 276
GLY A 204
ILE A  38
 None
None
NA  A1392 (-3.3A)
None
NAP  A1390 (-4.5A)
NAP  A1390 ( 4.6A)
 1.19A 5e5kA-2v6gA:
undetectable		 5e5kA-2v6gA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		4 / 7 ILE A 340
GLY A 339
PHE A 287
PHE A 237
 None
 1.12A 5hieA-2v6gA:
undetectable		 5hieA-2v6gA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MLM_A_STRA401_1
(-)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		6 / 12 LYS A 147
MET A 150
PHE A 153
MET A 215
SER A 248
CYH A 352
 NAP  A1390 (-4.5A)
None
None
None
None
None
 0.85A 5mlmA-2v6gA:
58.6		 5mlmA-2v6gA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MLM_A_STRA401_1
(-)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		7 / 12 MET A 150
PHE A 153
ASN A 205
MET A 215
ALA A 243
SER A 248
CYH A 352
 None
 0.62A 5mlmA-2v6gA:
58.6		 5mlmA-2v6gA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2v6g PROGESTERONE
5-BETA-REDUCTASE
(Digitalis
lanata) 		8 / 12 ARG A 146
LYS A 147
PHE A 153
ASN A 205
MET A 215
SER A 248
TRP A 284
CYH A 352
 None
NAP  A1390 (-4.5A)
None
None
None
None
None
None
 0.72A 6gsdA-2v6gA:
58.9		 6gsdA-2v6gA:
89.09