SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 12 LEU A 105
VAL A 110
SER A 266
ALA A 268
PRO A 135
 None
 1.16A 1dfoB-2v6jA:
undetectable		 1dfoB-2v6jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 12 LEU A 308
LEU A 307
LEU A  85
ILE A 116
ARG A 113
 None
 1.19A 1tw4B-2v6jA:
undetectable		 1tw4B-2v6jA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 5 ALA A 235
ILE A 274
ILE A 284
ASP A 283
 None
 1.10A 2h4jA-2v6jA:
3.9		 2h4jA-2v6jA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 12 PHE A 423
LEU A 355
CYH A 376
VAL A 345
LEU A 338
 None
 1.38A 2hc4A-2v6jA:
undetectable		 2hc4A-2v6jA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		3 / 3 ARG A 412
THR A 302
VAL A 299
 None
 0.87A 2q64A-2v6jA:
undetectable		 2q64A-2v6jA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 10 PHE A 206
TYR A 210
VAL A 221
VAL A 175
ILE A 226
 None
 1.23A 2qboA-2v6jA:
undetectable		 2qboA-2v6jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 7 GLY A 411
ASP A 410
VAL A 254
LEU A 355
 None
 0.76A 2uyqA-2v6jA:
4.1		 2uyqA-2v6jA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 12 LEU A 105
VAL A 110
SER A 266
ALA A 268
PRO A 135
 None
 1.08A 2vmyA-2v6jA:
undetectable		 2vmyA-2v6jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 5 ILE A  36
ARG A 113
MET A 130
THR A 131
 None
 1.21A 3abkN-2v6jA:
undetectable
3abkW-2v6jA:
undetectable		 3abkN-2v6jA:
20.93
3abkW-2v6jA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		3 / 3 GLY A 188
TRP A 176
VAL A 178
 None
 0.61A 3n62B-2v6jA:
undetectable		 3n62B-2v6jA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		3 / 3 GLY A 188
TRP A 176
VAL A 178
 None
 0.59A 3n65B-2v6jA:
undetectable		 3n65B-2v6jA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		3 / 3 GLY A 188
TRP A 176
VAL A 178
 None
 0.57A 3n66B-2v6jA:
undetectable		 3n66B-2v6jA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 8 LEU A 105
ALA A 111
TRP A 301
GLY A 297
 None
 0.90A 3ny4A-2v6jA:
undetectable		 3ny4A-2v6jA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 7 THR A 223
VAL A 238
ASP A 240
VAL A 175
 None
 0.84A 4cp4A-2v6jA:
undetectable		 4cp4A-2v6jA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 5 SER A 347
LYS A 344
ARG A 343
LEU A  86
 None
 1.22A 4ifxA-2v6jA:
undetectable		 4ifxA-2v6jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 5 SER A 347
LYS A 344
ARG A 343
LEU A  86
 None
 1.17A 4ig1A-2v6jA:
undetectable		 4ig1A-2v6jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 10 THR A  47
SER A  45
TYR A  58
GLU A 101
ASP A 100
 None
 1.46A 4qb9C-2v6jA:
0.0		 4qb9C-2v6jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 12 THR A  47
SER A  45
TYR A  58
GLU A 101
ASP A 100
 None
 1.49A 4qb9E-2v6jA:
undetectable		 4qb9E-2v6jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 11 GLY A 114
LEU A 321
GLU A 325
ALA A 108
ASP A 106
 None
 1.32A 4wnuC-2v6jA:
undetectable		 4wnuC-2v6jA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 5 SER A 347
LYS A 344
ARG A 343
LEU A  86
 None
 1.15A 4xdtA-2v6jA:
undetectable		 4xdtA-2v6jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 11 LEU A 321
GLU A 117
ASP A 124
GLY A 123
MET A 122
 None
 1.43A 4zjqA-2v6jA:
0.0		 4zjqA-2v6jA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2v6j RNA HELICASE
(Kokobera
virus) 		3 / 3 THR A 133
THR A 131
PHE A 104
 None
 0.83A 5cxvA-2v6jA:
undetectable		 5cxvA-2v6jA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2v6j RNA HELICASE
(Kokobera
virus) 		4 / 6 ARG A 273
PHE A 206
GLU A 101
VAL A  43
 None
 1.20A 5h4dA-2v6jA:
3.2		 5h4dA-2v6jA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		3 / 3 PRO A 324
ARG A 326
GLU A 325
 None
 0.85A 5j6hA-2v6jA:
undetectable		 5j6hA-2v6jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 12 HIS A  78
ALA A  38
PHE A  75
THR A  34
LEU A  20
 None
 1.23A 5m54B-2v6jA:
undetectable		 5m54B-2v6jA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		5 / 12 HIS A  78
ALA A  38
PHE A  75
THR A  34
LEU A  20
 None
 1.23A 5m54E-2v6jA:
2.6		 5m54E-2v6jA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2v6j RNA HELICASE
(Kokobera
virus) 		3 / 3 GLY A 188
TRP A 176
VAL A 178
 None
 0.61A 5vuoB-2v6jA:
undetectable		 5vuoB-2v6jA:
23.58