SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 11 LEU A 538
ASN A 592
ILE A 570
LEU A 548
PHE A 578
 None
 1.39A 1tw4A-2v70A:
undetectable		 1tw4A-2v70A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 6 LEU A 589
SER A 566
PHE A 565
ILE A 587
 None
 1.02A 3ko0S-2v70A:
undetectable		 3ko0S-2v70A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 11 GLN A 641
PRO A 665
ASN A 664
LEU A 661
ALA A 649
 None
 1.42A 3n23C-2v70A:
undetectable		 3n23C-2v70A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 8 LEU A 589
LEU A 613
LEU A 637
ILE A 587
VAL A 632
 None
 1.33A 4klaA-2v70A:
undetectable		 4klaA-2v70A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 5 VAL A 597
VAL A 621
GLY A 622
PHE A 626
 None
 1.05A 5d4nA-2v70A:
undetectable
5d4nC-2v70A:
undetectable		 5d4nA-2v70A:
17.65
5d4nC-2v70A:
17.65