SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.82A 1grmA-2v72A:
undetectable		 1grmA-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.82A 1grmB-2v72A:
undetectable		 1grmB-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.84A 1jnoA-2v72A:
undetectable		 1jnoA-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.84A 1jnoB-2v72A:
undetectable		 1jnoB-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.87A 1jo3A-2v72A:
undetectable		 1jo3A-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.87A 1jo3B-2v72A:
undetectable		 1jo3B-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.80A 1jo4A-2v72A:
undetectable		 1jo4A-2v72A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.80A 1jo4B-2v72A:
undetectable		 1jo4B-2v72A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.74A 1magA-2v72A:
undetectable		 1magA-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.74A 1magB-2v72A:
undetectable		 1magB-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.85A 1ng8A-2v72A:
undetectable		 1ng8A-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.85A 1ng8B-2v72A:
undetectable		 1ng8B-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.77A 1nrmA-2v72A:
undetectable		 1nrmA-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.76A 1nrmB-2v72A:
undetectable		 1nrmB-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.79A 1nruA-2v72A:
undetectable		 1nruA-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.79A 1nruB-2v72A:
undetectable		 1nruB-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.83A 1nt6A-2v72A:
undetectable		 1nt6A-2v72A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ALA A  64
VAL A 106
TRP A  97
 None
 0.83A 1nt6B-2v72A:
undetectable		 1nt6B-2v72A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 11 ILE A  63
ILE A 112
PHE A 108
ILE A 119
VAL A  52
 None
 0.92A 3tmzA-2v72A:
undetectable		 3tmzA-2v72A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  74
GLY A  71
ASN A  72
ALA A 121
LEU A  46
 None
 1.12A 3vywC-2v72A:
undetectable		 3vywC-2v72A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 7 THR A  66
ALA A  64
SER A  62
THR A 105
 None
 0.89A 4d7bA-2v72A:
1.6		 4d7bA-2v72A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 7 ALA A  93
PHE A 108
ALA A  83
THR A  90
 None
 0.77A 4du2B-2v72A:
undetectable		 4du2B-2v72A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 LEU A 134
VAL A 136
PHE A 108
LEU A  91
VAL A 106
 None
 1.22A 4nc3A-2v72A:
undetectable		 4nc3A-2v72A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 2v72 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 LYS A  39
TRP A  40
SER A  17
 None
GAL  A1140 (-3.5A)
None
 1.40A 5nwwA-2v72A:
undetectable		 5nwwA-2v72A:
12.86