SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WSV_B_THHB4001_0 (AMINOMETHYLTRANSFERA SE)	2v75	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2 (Saccharomyces cerevisiae)	5 / 12	LEU A 52 ILE A 35 VAL A 36 PHE A 24 TYR A 30	None	1.18A	1wsvB-2v75A: undetectable	1wsvB-2v75A: 17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D39_B_MTLB870_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	2v75	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2 (Saccharomyces cerevisiae)	4 / 7	ASN A 9 GLU A 16 ILE A 13 ASN A 86	None	0.90A	4d39B-2v75A: undetectable	4d39B-2v75A: 12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1G_B_LNLB701_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2v75	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2 (Saccharomyces cerevisiae)	4 / 7	VAL A 45 VAL A 49 LEU A 52 VAL A 59	None	1.11A	4e1gB-2v75A: 3.3	4e1gB-2v75A: 10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LUH_A_ACTA610_0 (SERUM ALBUMIN)	2v75	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2 (Saccharomyces cerevisiae)	3 / 3	VAL A 59 SER A 60 THR A 63	None	0.33A	4luhA-2v75A: 4.6	4luhA-2v75A: 12.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WSV_B_THHB4001_0","AMINOMETHYLTRANSFERASE","2v75","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2","Saccharomyces cerevisiae",5,"LEU A  52;ILE A  35;VAL A  36;PHE A  24;TYR A  30","None","1.18A","1wsvB-2v75A:undetectable","1wsvB-2v75A:17.26"],["4D39_B_MTLB870_0","NITRIC OXIDE SYNTHASE, ENDOTHELIAL","2v75","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2","Saccharomyces cerevisiae",4,"ASN A   9;GLU A  16;ILE A  13;ASN A  86","None","0.90A","4d39B-2v75A:undetectable","4d39B-2v75A:12.36"],["4E1G_B_LNLB701_2","PROSTAGLANDIN G\/H SYNTHASE 2","2v75","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2","Saccharomyces cerevisiae",4,"VAL A  45;VAL A  49;LEU A  52;VAL A  59","None","1.11A","4e1gB-2v75A:3.3","4e1gB-2v75A:10.48"],["4LUH_A_ACTA610_0","SERUM ALBUMIN","2v75","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN NAB2","Saccharomyces cerevisiae",3,"VAL A  59;SER A  60;THR A  63","None","0.33A","4luhA-2v75A:4.6","4luhA-2v75A:12.30"]]