SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 10 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
0.99A 1c9sN-2v7gA:
undetectable
1c9sO-2v7gA:
undetectable
1c9sN-2v7gA:
8.79
1c9sO-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 11 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.01A 1c9sP-2v7gA:
undetectable
1c9sQ-2v7gA:
undetectable
1c9sP-2v7gA:
8.79
1c9sQ-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 10 GLY A 503
SER A 136
GLY A 492
HIS A 501
ALA A 134
None
1.00A 1c9sL-2v7gA:
undetectable
1c9sV-2v7gA:
undetectable
1c9sL-2v7gA:
8.79
1c9sV-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 LEU A 171
THR A 265
ALA A 173
LEU A 194
None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
0.94A 1etb2-2v7gA:
1.6
1etb2-2v7gA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 11 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.01A 1gtfQ-2v7gA:
undetectable
1gtfR-2v7gA:
undetectable
1gtfQ-2v7gA:
8.79
1gtfR-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 11 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.02A 1gtfS-2v7gA:
undetectable
1gtfT-2v7gA:
undetectable
1gtfS-2v7gA:
8.79
1gtfT-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 11 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.05A 1gtnT-2v7gA:
undetectable
1gtnU-2v7gA:
undetectable
1gtnT-2v7gA:
8.79
1gtnU-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 ALA A 104
LEU A 102
ALA A 475
THR A 479
None
0.90A 1ie4B-2v7gA:
1.6
1ie4D-2v7gA:
1.6
1ie4B-2v7gA:
12.84
1ie4D-2v7gA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 ASP A 269
ASN A 272
MET A 496
LEU A 108
None
0.89A 1lhvA-2v7gA:
undetectable
1lhvA-2v7gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.86A 1m8eB-2v7gA:
undetectable
1m8eB-2v7gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 LEU A 445
ASP A 446
GLY A 357
ARG A 418
NAD  A3001 (-4.1A)
None
None
None
0.56A 1mt1G-2v7gA:
undetectable
1mt1J-2v7gA:
undetectable
1mt1G-2v7gA:
7.71
1mt1J-2v7gA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ARG A 418
LEU A 445
ASP A 446
GLY A 357
None
NAD  A3001 (-4.1A)
None
None
0.57A 1mt1H-2v7gA:
undetectable
1mt1K-2v7gA:
undetectable
1mt1H-2v7gA:
13.19
1mt1K-2v7gA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ARG A 418
LEU A 445
ASP A 446
GLY A 357
None
NAD  A3001 (-4.1A)
None
None
0.56A 1n13D-2v7gA:
undetectable
1n13E-2v7gA:
undetectable
1n13D-2v7gA:
13.19
1n13E-2v7gA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 LEU A 445
ASP A 446
GLY A 357
ARG A 418
NAD  A3001 (-4.1A)
None
None
None
0.59A 1n13A-2v7gA:
undetectable
1n13F-2v7gA:
undetectable
1n13A-2v7gA:
7.71
1n13F-2v7gA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 ARG A 418
LEU A 445
ASP A 446
GLY A 357
None
NAD  A3001 (-4.1A)
None
None
0.57A 1n13H-2v7gA:
undetectable
1n13K-2v7gA:
undetectable
1n13H-2v7gA:
13.19
1n13K-2v7gA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 445
ASP A 446
GLY A 357
ARG A 418
NAD  A3001 (-4.1A)
None
None
None
0.57A 1n13G-2v7gA:
undetectable
1n13J-2v7gA:
undetectable
1n13G-2v7gA:
7.71
1n13J-2v7gA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.87A 1nodB-2v7gA:
undetectable
1nodB-2v7gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.94A 1qomA-2v7gA:
undetectable
1qomA-2v7gA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 VAL A  69
VAL A  83
TYR A 129
ARG A  32
None
0.96A 1t46A-2v7gA:
undetectable
1t46A-2v7gA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 171
THR A 265
ALA A 173
LEU A 194
None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
1.00A 1tyrB-2v7gA:
undetectable
1tyrB-2v7gA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ALA A 227
ILE A 226
ILE A 238
ASP A 221
None
0.86A 1upfB-2v7gA:
undetectable
1upfB-2v7gA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.04A 1utdO-2v7gA:
undetectable
1utdP-2v7gA:
undetectable
1utdO-2v7gA:
8.79
1utdP-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 11 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.04A 1utdP-2v7gA:
undetectable
1utdQ-2v7gA:
undetectable
1utdP-2v7gA:
8.79
1utdQ-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 11 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.03A 1utdS-2v7gA:
undetectable
1utdT-2v7gA:
undetectable
1utdS-2v7gA:
8.79
1utdT-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 10 GLY A 492
HIS A 501
ALA A 134
GLY A 503
SER A 136
None
1.06A 1utdU-2v7gA:
undetectable
1utdV-2v7gA:
undetectable
1utdU-2v7gA:
8.79
1utdV-2v7gA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 7 SER A 237
ASP A 213
SER A 193
ASN A 195
GLN A 182
None
1.42A 2cmlA-2v7gA:
undetectable
2cmlA-2v7gA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 8 SER A 237
ASP A 213
SER A 193
ASN A 195
GLN A 182
None
1.43A 2cmlB-2v7gA:
undetectable
2cmlB-2v7gA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 8 SER A 237
ASP A 213
SER A 193
ASN A 195
GLN A 182
None
1.49A 2cmlD-2v7gA:
undetectable
2cmlD-2v7gA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 ARG A   8
GLU A  11
PRO A  40
ALA A  43
None
1.14A 2ejfB-2v7gA:
0.9
2ejfB-2v7gA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ARG A   8
GLU A  11
PRO A  40
ALA A  43
None
1.18A 2ejgA-2v7gA:
undetectable
2ejgA-2v7gA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.91A 2nodB-2v7gA:
undetectable
2nodB-2v7gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 LEU A 394
GLN A 147
VAL A 413
LEU A 421
THR A 376
None
None
GOL  A1561 ( 4.3A)
None
None
1.30A 2q7kA-2v7gA:
undetectable
2q7kA-2v7gA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ARG A 418
LEU A 445
ASP A 446
GLY A 357
None
NAD  A3001 (-4.1A)
None
None
0.61A 2qqcD-2v7gA:
undetectable
2qqcE-2v7gA:
undetectable
2qqcD-2v7gA:
13.64
2qqcE-2v7gA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 ARG A 418
LEU A 445
ASP A 446
GLY A 357
None
NAD  A3001 (-4.1A)
None
None
0.59A 2qqcH-2v7gA:
undetectable
2qqcK-2v7gA:
undetectable
2qqcH-2v7gA:
13.64
2qqcK-2v7gA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 ARG A 418
LEU A 445
ASP A 446
GLY A 357
None
NAD  A3001 (-4.1A)
None
None
0.62A 2qqdB-2v7gA:
undetectable
2qqdC-2v7gA:
undetectable
2qqdB-2v7gA:
13.46
2qqdC-2v7gA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 LYS A 420
LEU A 417
ALA A 419
THR A 523
None
0.99A 2roxB-2v7gA:
undetectable
2roxB-2v7gA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 PHE A 205
GLY A 141
ASP A  39
TYR A 139
None
None
None
ACT  A1558 (-4.7A)
1.15A 3aruA-2v7gA:
2.1
3aruA-2v7gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 SER A 435
GLY A  17
GLY A 368
None
0.53A 3bogA-2v7gA:
undetectable
3bogC-2v7gA:
undetectable
3bogA-2v7gA:
undetectable
3bogC-2v7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 GLY A 493
HIS A 490
ARG A 351
PHE A 498
SER A 452
NAD  A3001 (-3.1A)
None
None
None
None
1.48A 3bxoB-2v7gA:
8.3
3bxoB-2v7gA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 GLY A 174
GLY A 176
GLU A 197
ASN A 243
ALA A 244
NAD  A3001 ( 3.8A)
NAD  A3001 (-3.1A)
NAD  A3001 (-2.7A)
NAD  A3001 (-3.2A)
NAD  A3001 (-3.5A)
1.03A 3ckkA-2v7gA:
5.1
3ckkA-2v7gA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 LEU A 223
GLU A 250
ILE A 247
None
0.60A 3czhA-2v7gA:
undetectable
3czhA-2v7gA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.87A 3e68A-2v7gA:
undetectable
3e68A-2v7gA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.84A 3e6tB-2v7gA:
undetectable
3e6tB-2v7gA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.83A 3e7iB-2v7gA:
undetectable
3e7iB-2v7gA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 LEU A  31
THR A  27
ALA A  29
LEU A 366
LEU A  20
None
1.11A 3hm1A-2v7gA:
undetectable
3hm1A-2v7gA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.99A 3nw2A-2v7gA:
undetectable
3nw2A-2v7gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 418
ILE A 410
TRP A 412
None
0.94A 3nw2B-2v7gA:
undetectable
3nw2B-2v7gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 GLY A 497
GLY A 491
ASN A 107
GLU A 333
TRP A 115
None
1.17A 3p2kB-2v7gA:
4.5
3p2kB-2v7gA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 GLY A 492
HIS A 490
LEU A 445
PHE A 498
SER A 452
None
None
NAD  A3001 (-4.1A)
None
None
1.16A 3pfgA-2v7gA:
7.1
3pfgA-2v7gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 GLY A 493
HIS A 490
LEU A 445
PHE A 498
SER A 452
NAD  A3001 (-3.1A)
None
NAD  A3001 (-4.1A)
None
None
1.38A 3pfgA-2v7gA:
7.1
3pfgA-2v7gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 LEU A 383
VAL A 380
PHE A 425
PHE A 361
None
1.12A 3soaA-2v7gA:
1.3
3soaA-2v7gA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ALA A 348
PRO A 347
ARG A 455
ARG A 328
None
None
NAD  A3001 (-4.0A)
None
1.14A 3twpA-2v7gA:
undetectable
3twpA-2v7gA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ALA A 348
PRO A 347
ARG A 455
ARG A 328
None
None
NAD  A3001 (-4.0A)
None
1.08A 3twpB-2v7gA:
undetectable
3twpB-2v7gA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A  16
MET A  33
ARG A  32
None
1.34A 3uvvA-2v7gA:
undetectable
3uvvA-2v7gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 THR A  73
VAL A  69
GLU A  28
None
0.50A 3v4tA-2v7gA:
undetectable
3v4tD-2v7gA:
undetectable
3v4tA-2v7gA:
24.91
3v4tD-2v7gA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 ILE A  12
VAL A  69
VAL A 505
LEU A 366
VAL A 439
None
1.18A 3w68C-2v7gA:
undetectable
3w68C-2v7gA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 11 ASN A 105
ARG A 455
HIS A 444
SER A 106
GLY A  53
None
NAD  A3001 (-4.0A)
None
None
NAD  A3001 (-3.2A)
1.50A 4a99C-2v7gA:
0.1
4a99C-2v7gA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 GLU A 246
GLU A 250
LYS A 253
ARG A 254
None
0.87A 4bqfB-2v7gA:
undetectable
4bqfB-2v7gA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 THR A 484
LEU A  72
VAL A 439
VAL A 507
None
0.97A 4cp4A-2v7gA:
undetectable
4cp4A-2v7gA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 ASN A 107
VAL A  83
ILE A 103
ALA A 475
None
1.02A 4eyzA-2v7gA:
undetectable
4eyzA-2v7gA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 ASN A 107
VAL A  83
ILE A 103
ALA A 475
None
1.00A 4eyzB-2v7gA:
undetectable
4eyzB-2v7gA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 LEU A  72
LEU A  81
VAL A 101
ILE A 103
None
0.86A 4oj4A-2v7gA:
undetectable
4oj4A-2v7gA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 LEU A 488
ASN A 107
LEU A 102
VAL A  89
None
1.07A 4okbA-2v7gA:
undetectable
4okbA-2v7gA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 6 LEU A 171
THR A 265
ALA A 173
LEU A 194
None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
0.99A 4pwjA-2v7gA:
1.3
4pwjA-2v7gA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 171
THR A 265
ALA A 173
LEU A 194
None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
1.01A 4pwjB-2v7gA:
undetectable
4pwjB-2v7gA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 THR A  27
THR A 484
ALA A 483
THR A  80
None
1.01A 4qw0K-2v7gA:
undetectable
4qw0K-2v7gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 THR A  27
THR A 484
ALA A 483
THR A  80
None
1.01A 4qw0Y-2v7gA:
undetectable
4qw0Y-2v7gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 175
GLU A  44
GLY A 179
GLY A 180
None
NAD  A3001 (-4.6A)
NAD  A3001 (-3.7A)
None
0.78A 5a06A-2v7gA:
undetectable
5a06A-2v7gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 175
GLU A  44
GLY A 179
GLY A 180
None
NAD  A3001 (-4.6A)
NAD  A3001 (-3.7A)
None
0.80A 5a06B-2v7gA:
undetectable
5a06B-2v7gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 175
GLU A  44
GLY A 179
GLY A 180
None
NAD  A3001 (-4.6A)
NAD  A3001 (-3.7A)
None
0.81A 5a06C-2v7gA:
undetectable
5a06C-2v7gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 175
GLU A  44
GLY A 179
GLY A 180
None
NAD  A3001 (-4.6A)
NAD  A3001 (-3.7A)
None
0.79A 5a06E-2v7gA:
undetectable
5a06E-2v7gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 175
GLU A  44
GLY A 179
GLY A 180
None
NAD  A3001 (-4.6A)
NAD  A3001 (-3.7A)
None
0.78A 5a06F-2v7gA:
undetectable
5a06F-2v7gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 LEU A 171
THR A 265
ALA A 173
LEU A 194
None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
0.98A 5bojB-2v7gA:
1.4
5bojB-2v7gA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 7 ALA A 541
ASP A 525
ARG A 442
GLY A 359
None
0.80A 5bs8A-2v7gA:
undetectable
5bs8C-2v7gA:
undetectable
5bs8D-2v7gA:
undetectable
5bs8A-2v7gA:
22.44
5bs8C-2v7gA:
22.44
5bs8D-2v7gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 4 GLN A 264
THR A 265
GLU A 197
LEU A 194
NAD  A3001 (-3.9A)
NAD  A3001 (-4.2A)
NAD  A3001 (-2.7A)
None
1.18A 5m66A-2v7gA:
7.3
5m66A-2v7gA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 5 SER A 142
ALA A 181
GLN A 147
THR A 149
None
1.30A 5n0tA-2v7gA:
undetectable
5n0tA-2v7gA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
3 / 3 ARG A 362
PRO A 360
TYR A  52
ACT  A1558 (-2.9A)
None
ACT  A1558 ( 4.3A)
1.03A 5tzoB-2v7gA:
undetectable
5tzoB-2v7gA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 12 GLY A 180
GLY A 144
GLY A 141
GLY A 177
ILE A 410
None
ACT  A1558 (-3.4A)
None
NAD  A3001 (-3.8A)
None
0.92A 5wz2C-2v7gA:
4.8
5wz2C-2v7gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
4 / 8 ALA A 156
THR A 152
ALA A 181
TRP A 393
None
1.02A 5x2tI-2v7gA:
undetectable
5x2tJ-2v7gA:
undetectable
5x2tK-2v7gA:
undetectable
5x2tL-2v7gA:
undetectable
5x2tI-2v7gA:
13.36
5x2tJ-2v7gA:
13.92
5x2tK-2v7gA:
13.36
5x2tL-2v7gA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_C_9F2C302_1
(BETA-LACTAMASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 10 THR A 187
PRO A 183
TYR A 211
THR A 209
ASP A 221
None
1.50A 6b68C-2v7gA:
0.0
6b68D-2v7gA:
0.0
6b68C-2v7gA:
9.11
6b68D-2v7gA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_A_9F2A302_1
(BETA-LACTAMASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 9 THR A 187
PRO A 183
TYR A 211
THR A 209
ASP A 221
None
1.47A 6b69A-2v7gA:
0.0
6b69B-2v7gA:
0.0
6b69A-2v7gA:
9.11
6b69B-2v7gA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_C_9F2C302_1
(BETA-LACTAMASE)
2v7g UROCANATE HYDRATASE
(Pseudomonas
putida)
5 / 9 THR A 187
PRO A 183
TYR A 211
THR A 209
ASP A 221
None
1.47A 6b69C-2v7gA:
0.0
6b69D-2v7gA:
0.0
6b69C-2v7gA:
9.11
6b69D-2v7gA:
9.11