SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		4 / 8 GLN A  99
PHE A  92
ASN A 186
ASP A 102
 None
GOL  A1209 (-4.5A)
None
None
 1.17A 1rs7B-2v7sA:
undetectable		 1rs7B-2v7sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		4 / 8 GLN A  99
PHE A  92
ASN A 186
ASP A 102
 None
GOL  A1209 (-4.5A)
None
None
 1.17A 1zzuA-2v7sA:
undetectable		 1zzuA-2v7sA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 150
TYR A 173
GLY A 172
ASP A 190
 None
 1.29A 3kl3A-2v7sA:
undetectable		 3kl3A-2v7sA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		4 / 8 GLN A  99
PHE A  92
ASN A 186
ASP A 102
 None
GOL  A1209 (-4.5A)
None
None
 1.22A 3n62A-2v7sA:
undetectable		 3n62A-2v7sA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		4 / 8 GLN A  99
PHE A  92
ASN A 186
ASP A 102
 None
GOL  A1209 (-4.5A)
None
None
 1.23A 3n62B-2v7sA:
undetectable		 3n62B-2v7sA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		4 / 8 GLN A  99
PHE A  92
ASN A 186
ASP A 102
 None
GOL  A1209 (-4.5A)
None
None
 1.18A 3n66B-2v7sA:
undetectable		 3n66B-2v7sA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 127
PHE A 126
ALA A  78
ASP A  79
SER A  82
 GOL  A1208 (-3.3A)
None
None
None
None
 0.82A 3tbgB-2v7sA:
undetectable		 3tbgB-2v7sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 127
PHE A 126
ALA A  78
ASP A  79
SER A  82
 GOL  A1208 (-3.3A)
None
None
None
None
 0.81A 3tbgD-2v7sA:
undetectable		 3tbgD-2v7sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_C_ACTC1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 118
GLN A 169
GLU A 174
THR A 188
 None
 1.33A 4eahC-2v7sA:
1.3
4eahH-2v7sA:
0.0		 4eahC-2v7sA:
21.54
4eahH-2v7sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  76
GLU A  68
GLY A 189
TYR A 149
GLU A 145
 None
 1.28A 4jlgB-2v7sA:
undetectable		 4jlgB-2v7sA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 126
ALA A  78
ASP A  79
SER A  82
ALA A  83
 None
 0.77A 4wnuB-2v7sA:
undetectable		 4wnuB-2v7sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 127
PHE A 126
ALA A  78
ASP A  79
SER A  82
 GOL  A1208 (-3.3A)
None
None
None
None
 0.89A 4wnuC-2v7sA:
undetectable		 4wnuC-2v7sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		6 / 10 GLY A 127
PHE A 126
ALA A  78
ASP A  79
SER A  82
ALA A  83
 GOL  A1208 (-3.3A)
None
None
None
None
None
 0.99A 4wnuD-2v7sA:
undetectable		 4wnuD-2v7sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  70
ALA A  74
LEU A 185
PHE A 175
ILE A 120
 None
 1.05A 5ljcA-2v7sA:
undetectable		 5ljcA-2v7sA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 139
GLU A 145
ILE A 187
VAL A 168
TYR A 149
 None
 1.36A 5vlmB-2v7sA:
undetectable		 5vlmB-2v7sA:
23.43