SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 8 ALA A 388
LEU A 305
LEU A 308
LEU A 329
ALA A 304
None
1.36A 1e7cA-2v8jA:
2.9
1e7cA-2v8jA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 6 THR A 514
PHE A 111
PHE A  49
GLY A 121
None
0.97A 1icuA-2v8jA:
undetectable
1icuB-2v8jA:
undetectable
1icuA-2v8jA:
17.76
1icuB-2v8jA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 6 PHE A  49
GLY A 121
THR A 514
PHE A 111
None
0.99A 1icuA-2v8jA:
undetectable
1icuB-2v8jA:
undetectable
1icuA-2v8jA:
17.76
1icuB-2v8jA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 5 PHE A  49
GLY A 121
THR A 514
PHE A 111
None
0.91A 1icuC-2v8jA:
undetectable
1icuD-2v8jA:
undetectable
1icuC-2v8jA:
17.76
1icuD-2v8jA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 5 PHE A  49
GLY A 121
THR A 514
PHE A 111
None
1.07A 1icvA-2v8jA:
undetectable
1icvB-2v8jA:
undetectable
1icvA-2v8jA:
17.76
1icvB-2v8jA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 8 ALA A  55
LEU A  57
GLU A 124
THR A 514
None
0.89A 1ie4B-2v8jA:
undetectable
1ie4D-2v8jA:
undetectable
1ie4B-2v8jA:
10.80
1ie4D-2v8jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 11 HIS A 172
GLU A 126
HIS A 109
GLU A 130
PHE A 201
MN  A1540 (-3.4A)
MN  A1540 ( 4.4A)
MN  A1540 (-3.3A)
MN  A1540 (-2.6A)
None
1.39A 1j37A-2v8jA:
2.3
1j37A-2v8jA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 11 HIS A 172
GLU A 126
HIS A 109
GLU A 130
PHE A 201
MN  A1540 (-3.4A)
MN  A1540 ( 4.4A)
MN  A1540 (-3.3A)
MN  A1540 (-2.6A)
None
1.38A 1j37B-2v8jA:
2.3
1j37B-2v8jA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 HIS A 172
GLU A 126
HIS A 109
GLU A 130
PHE A 201
MN  A1540 (-3.4A)
MN  A1540 ( 4.4A)
MN  A1540 (-3.3A)
MN  A1540 (-2.6A)
None
1.37A 1o86A-2v8jA:
3.1
1o86A-2v8jA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 GLU A 126
HIS A 172
HIS A 109
MN  A1540 ( 4.4A)
MN  A1540 (-3.4A)
MN  A1540 (-3.3A)
0.58A 1oe2A-2v8jA:
undetectable
1oe2A-2v8jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 GLU A 130
HIS A 109
HIS A 172
MN  A1540 (-2.6A)
MN  A1540 (-3.3A)
MN  A1540 (-3.4A)
0.71A 1oe2A-2v8jA:
undetectable
1oe2A-2v8jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 11 ALA A  86
PRO A 136
LEU A  17
ALA A  20
VAL A  16
None
1.07A 1rv7A-2v8jA:
undetectable
1rv7B-2v8jA:
undetectable
1rv7A-2v8jA:
10.37
1rv7B-2v8jA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 ASP A 271
ARG A 275
ARG A 272
None
1.10A 2j9dA-2v8jA:
undetectable
2j9dC-2v8jA:
undetectable
2j9dA-2v8jA:
13.64
2j9dC-2v8jA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 GLU A 280
TYR A 357
THR A 370
LEU A 372
LEU A 292
None
1.03A 2mjiA-2v8jA:
undetectable
2mjiA-2v8jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 PHE A 344
SER A 384
LEU A 382
None
0.83A 2w1bA-2v8jA:
undetectable
2w1bA-2v8jA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 6 SER A  30
VAL A 112
TYR A  97
ASP A  22
None
1.13A 2x45A-2v8jA:
undetectable
2x45A-2v8jA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 SER A  30
VAL A 112
TYR A  97
ASP A  22
None
1.14A 2x45B-2v8jA:
undetectable
2x45B-2v8jA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 SER A  30
VAL A 112
TYR A  97
ASP A  22
None
1.14A 2x45C-2v8jA:
undetectable
2x45C-2v8jA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 11 HIS A 172
GLU A 126
HIS A 109
GLU A 130
PHE A 201
MN  A1540 (-3.4A)
MN  A1540 ( 4.4A)
MN  A1540 (-3.3A)
MN  A1540 (-2.6A)
None
1.40A 2x8zA-2v8jA:
2.2
2x8zA-2v8jA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 LEU A  57
ASN A  59
PHE A 535
GLY A  36
THR A 529
None
1.00A 3c6gA-2v8jA:
undetectable
3c6gA-2v8jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 LEU A  57
ASN A  59
PHE A 535
GLY A  36
THR A 529
None
1.03A 3c6gB-2v8jA:
undetectable
3c6gB-2v8jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 GLY A 512
PRO A 136
LEU A 131
None
0.34A 3hcpB-2v8jA:
undetectable
3hcpB-2v8jA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 LEU A 214
TYR A 210
ALA A 505
LEU A 314
LEU A 508
None
1.03A 3vw1B-2v8jA:
undetectable
3vw1B-2v8jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 11 HIS A 172
GLU A 126
HIS A 109
GLU A 130
PHE A 201
MN  A1540 (-3.4A)
MN  A1540 ( 4.4A)
MN  A1540 (-3.3A)
MN  A1540 (-2.6A)
None
1.38A 4c2pA-2v8jA:
3.3
4c2pA-2v8jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 6 GLY A  42
VAL A  37
PRO A  39
GLY A 469
None
0.77A 4dxuA-2v8jA:
undetectable
4dxuA-2v8jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 GLY A  42
VAL A  37
PRO A  39
GLY A 469
None
0.76A 4forA-2v8jA:
undetectable
4forA-2v8jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 LEU A  66
MET A  70
ASP A 468
None
0.67A 4j7xB-2v8jA:
undetectable
4j7xB-2v8jA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 8 ARG A 530
ASP A 531
ALA A  62
SER A  61
None
1.18A 4lv9A-2v8jA:
undetectable
4lv9B-2v8jA:
undetectable
4lv9A-2v8jA:
22.75
4lv9B-2v8jA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 GLU A 486
LEU A  66
LEU A 536
GLY A  36
ALA A  20
None
1.22A 4retC-2v8jA:
undetectable
4retC-2v8jA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 SER A 301
LEU A 305
ILE A 485
GLY A 378
VAL A 400
None
0.84A 4y8wC-2v8jA:
undetectable
4y8wC-2v8jA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 LEU A 396
VAL A 326
ASP A 327
None
0.60A 4y8wC-2v8jA:
undetectable
4y8wC-2v8jA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 LYS A 132
LEU A 131
GLY A 108
GLY A 107
None
0.69A 5a06A-2v8jA:
undetectable
5a06A-2v8jA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 LYS A 132
LEU A 131
GLY A 108
GLY A 107
None
0.70A 5a06B-2v8jA:
undetectable
5a06B-2v8jA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 LYS A 132
LEU A 131
GLY A 108
GLY A 107
None
0.70A 5a06C-2v8jA:
undetectable
5a06C-2v8jA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 LYS A 132
LEU A 131
GLY A 108
GLY A 107
None
0.69A 5a06E-2v8jA:
undetectable
5a06E-2v8jA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 7 LYS A 132
LEU A 131
GLY A 108
GLY A 107
None
0.71A 5a06F-2v8jA:
undetectable
5a06F-2v8jA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 6 LYS A   5
ARG A 498
SER A  77
LEU A  76
None
1.23A 5bphD-2v8jA:
undetectable
5bphD-2v8jA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 4 ALA A 204
PRO A 136
LEU A 104
HIS A 129
None
1.48A 5eskA-2v8jA:
undetectable
5eskA-2v8jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 8 HIS A 129
GLY A 108
GLY A 107
VAL A 128
None
0.73A 5f8yA-2v8jA:
undetectable
5f8yA-2v8jA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 8 HIS A 129
GLY A 108
GLY A 107
VAL A 128
None
0.78A 5f8yB-2v8jA:
undetectable
5f8yB-2v8jA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
5 / 12 LEU A 131
TYR A 135
PHE A 156
THR A 169
PHE A 513
None
1.28A 5fsaB-2v8jA:
undetectable
5fsaB-2v8jA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
4 / 6 LEU A 439
LYS A   5
GLU A 494
LEU A 497
None
1.25A 5xooA-2v8jA:
undetectable
5xooA-2v8jA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 TYR A 235
ASP A 233
GLN A 234
None
0.92A 6g1pA-2v8jA:
undetectable
6g1pA-2v8jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)
2v8j PECTATE LYASE
(Yersinia
enterocolitica)
3 / 3 ASP A  14
SER A  74
SER A  77
None
0.54A 6mxtA-2v8jA:
undetectable
6mxtA-2v8jA:
22.49