SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 12 PHE A  30
PHE A  29
PRO A  28
PHE A  27
ALA A 244
 None
 1.49A 1fm4A-2v8nA:
undetectable		 1fm4A-2v8nA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 5 GLY A 391
SER A 396
THR A 399
PHE A 392
 None
 1.28A 1kqbA-2v8nA:
undetectable
1kqbB-2v8nA:
undetectable		 1kqbA-2v8nA:
19.63
1kqbB-2v8nA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 5 GLY A 115
PRO A 123
ALA A 124
ILE A  80
 None
 0.95A 2aofA-2v8nA:
undetectable		 2aofA-2v8nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 5 LEU A  76
PRO A 123
ALA A 124
ILE A  80
 None
 0.76A 2aofB-2v8nA:
undetectable		 2aofB-2v8nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 5 LEU A  76
GLY A 115
ALA A 124
ILE A  80
 None
 0.84A 2aohB-2v8nA:
undetectable		 2aohB-2v8nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		3 / 3 TYR A  26
GLY A  24
PHE A  27
 None
 0.67A 2m2pB-2v8nA:
undetectable		 2m2pB-2v8nA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 12 LEU A  76
GLY A 115
PRO A 123
ALA A 124
ILE A  80
 None
 0.85A 2nmzA-2v8nA:
undetectable		 2nmzA-2v8nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 12 LEU A  76
GLY A 115
PRO A 123
ALA A 124
ILE A  80
 None
 0.90A 2nmzB-2v8nA:
undetectable		 2nmzB-2v8nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 12 ILE A  52
PHE A  27
PHE A  29
ILE A  32
ILE A  37
 None
 1.15A 2rlcA-2v8nA:
undetectable		 2rlcA-2v8nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 7 LEU A 216
ILE A 349
ALA A 291
ILE A 283
 None
 0.78A 2xkwA-2v8nA:
undetectable		 2xkwA-2v8nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 7 SER A 396
LEU A 222
LEU A 225
THR A 399
 None
 1.00A 3cfqA-2v8nA:
undetectable
3cfqB-2v8nA:
undetectable		 3cfqA-2v8nA:
12.95
3cfqB-2v8nA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		3 / 3 CYH A 148
PHE A  16
PHE A  20
 None
 0.94A 3cr5X-2v8nA:
0.0		 3cr5X-2v8nA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 8 LEU A 400
GLY A 391
ALA A 389
THR A 235
ILE A 230
 None
 1.44A 3jusB-2v8nA:
undetectable		 3jusB-2v8nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 9 LEU A 400
GLY A 391
ALA A 389
THR A 235
ILE A 230
 None
 1.44A 3jusB-2v8nA:
undetectable		 3jusB-2v8nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 12 PHE A 170
PHE A  29
ILE A 157
GLY A 173
PHE A  87
 None
 1.38A 3ps9A-2v8nA:
undetectable		 3ps9A-2v8nA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 9 LEU A 172
GLY A  24
ALA A  25
GLY A 262
VAL A 169
 None
 0.96A 3u7sA-2v8nA:
undetectable		 3u7sA-2v8nA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 11 THR A 248
ALA A 244
PHE A 162
VAL A 169
ILE A  37
 None
 1.17A 4claA-2v8nA:
undetectable		 4claA-2v8nA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 6 ALA A 369
GLY A 380
LEU A 385
VAL A 384
 None
 0.80A 4dubB-2v8nA:
undetectable		 4dubB-2v8nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 11 TRP A  33
LEU A  34
LEU A 114
GLY A 115
PHE A 118
 None
 0.87A 4fogD-2v8nA:
undetectable		 4fogD-2v8nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 7 LEU A 222
LEU A 225
THR A 399
SER A 396
 None
 1.03A 4ikjA-2v8nA:
undetectable
4ikjB-2v8nA:
undetectable		 4ikjA-2v8nA:
14.46
4ikjB-2v8nA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 8 SER A 396
LEU A 222
LEU A 225
THR A 399
 None
 0.99A 4ikjA-2v8nA:
undetectable
4ikjB-2v8nA:
undetectable		 4ikjA-2v8nA:
14.46
4ikjB-2v8nA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 7 SER A 396
LEU A 222
LEU A 225
THR A 399
 None
 1.02A 4ikkA-2v8nA:
undetectable
4ikkB-2v8nA:
undetectable		 4ikkA-2v8nA:
14.46
4ikkB-2v8nA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 7 LEU A 222
LEU A 225
THR A 399
SER A 396
 None
 0.97A 4iklA-2v8nA:
undetectable
4iklB-2v8nA:
undetectable		 4iklA-2v8nA:
14.46
4iklB-2v8nA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		5 / 12 GLN A 242
ALA A  50
ILE A  52
ASN A 245
LEU A  34
 None
 1.22A 4r3aA-2v8nA:
undetectable		 4r3aA-2v8nA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 6 SER A  41
GLY A 370
ASN A 371
ILE A  48
 None
 0.94A 5j4nA-2v8nA:
undetectable		 5j4nA-2v8nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 4 GLN A 379
THR A 310
LEU A 321
LEU A 318
 None
 1.16A 5m5kB-2v8nA:
undetectable		 5m5kB-2v8nA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		3 / 3 TRP A  10
MET A  11
ASN A   8
 None
 0.82A 5uc1B-2v8nA:
undetectable		 5uc1B-2v8nA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		3 / 3 TRP A  10
MET A  11
ASN A   8
 None
 0.81A 5uc1A-2v8nA:
undetectable		 5uc1A-2v8nA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 2v8n LACTOSE PERMEASE
(Escherichia
coli) 		4 / 8 GLY A 257
GLN A 256
THR A 253
PHE A 162
 None
 1.08A 6eqpA-2v8nA:
undetectable		 6eqpA-2v8nA:
11.30