SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		4 / 8 VAL A 601
HIS A 268
GLU A 491
ASP A 598
 None
 1.29A 1s3zA-2v8oA:
undetectable
1s3zB-2v8oA:
undetectable		 1s3zA-2v8oA:
17.45
1s3zB-2v8oA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		5 / 12 THR A 267
VAL A 545
ALA A 548
VAL A 601
VAL A 442
 None
 1.31A 2nniA-2v8oA:
undetectable		 2nniA-2v8oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		3 / 3 LEU A 547
PRO A 544
ARG A 441
 None
 0.61A 2qd4B-2v8oA:
4.0		 2qd4B-2v8oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		3 / 3 LEU A 547
PRO A 544
ARG A 441
 None
 0.62A 2qd5A-2v8oA:
3.4		 2qd5A-2v8oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		4 / 7 TRP A 403
TYR A 395
ILE A 384
SER A 412
 None
 1.00A 2xz5A-2v8oA:
undetectable
2xz5B-2v8oA:
undetectable		 2xz5A-2v8oA:
21.94
2xz5B-2v8oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		4 / 8 THR A 408
SER A 412
TRP A 403
TYR A 395
 None
 1.12A 2xz5A-2v8oA:
undetectable
2xz5C-2v8oA:
undetectable		 2xz5A-2v8oA:
21.94
2xz5C-2v8oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		4 / 7 ILE A 384
SER A 412
TRP A 403
TYR A 395
 None
 0.99A 2xz5D-2v8oA:
undetectable
2xz5E-2v8oA:
undetectable		 2xz5D-2v8oA:
21.94
2xz5E-2v8oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		3 / 3 LEU A 501
PRO A 502
LEU A 505
 None
 0.54A 3hcrA-2v8oA:
3.7		 3hcrA-2v8oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		5 / 12 GLY A 470
VAL A 336
LYS A 358
ALA A 420
ASP A 404
 None
 1.30A 3qowA-2v8oA:
3.2		 3qowA-2v8oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		3 / 3 TYR A 518
GLU A 513
TYR A 510
 None
 0.79A 3ug8A-2v8oA:
undetectable		 3ug8A-2v8oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		4 / 7 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 0.90A 4cp4A-2v8oA:
undetectable		 4cp4A-2v8oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		5 / 9 LEU A 505
ALA A 312
PHE A 282
GLU A 309
LEU A 270
 None
 1.44A 4la0B-2v8oA:
undetectable		 4la0B-2v8oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		4 / 6 LEU A 205
GLU A 286
VAL A 227
ALA A 230
 None
 1.19A 4nkvC-2v8oA:
undetectable		 4nkvC-2v8oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2v8o FLAVIVIRIN PROTEASE
NS3
(Murray
Valley
encephalitis
virus) 		3 / 3 THR A 318
THR A 316
PHE A 289
 None
 0.82A 5cxvA-2v8oA:
undetectable		 5cxvA-2v8oA:
20.90