SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 6 GLY A 239
GLY A 172
TYR A 175
SER A 168
 None
CDP  A1269 (-3.4A)
CDP  A1269 (-3.6A)
None
 0.79A 1eswA-2v8pA:
undetectable		 1eswA-2v8pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 8 ALA A 212
TYR A 216
GLY A 237
GLY A  90
 None
None
None
ADP  A1270 (-3.2A)
 0.87A 1rukH-2v8pA:
undetectable
1rukL-2v8pA:
undetectable		 1rukH-2v8pA:
20.71
1rukL-2v8pA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 5 TYR A  31
ALA A 101
ALA A   8
TYR A  37
 None
 1.27A 3d91A-2v8pA:
undetectable		 3d91A-2v8pA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 12 GLY A 237
ASN A 206
GLY A 239
GLY A 209
ASP A 210
 None
 1.02A 3huoB-2v8pA:
undetectable		 3huoB-2v8pA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 7 TYR A 175
ASN A 206
LEU A 208
SER A 236
 CDP  A1269 (-3.6A)
None
None
None
 1.35A 3lslA-2v8pA:
undetectable
3lslD-2v8pA:
undetectable		 3lslA-2v8pA:
22.62
3lslD-2v8pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 7 SER A 236
TYR A 175
ASN A 206
LEU A 208
 None
CDP  A1269 (-3.6A)
None
None
 1.35A 3lslA-2v8pA:
undetectable
3lslD-2v8pA:
undetectable		 3lslA-2v8pA:
22.62
3lslD-2v8pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 9 LEU A  14
VAL A 235
ILE A 211
ALA A 212
THR A 171
 None
CL  A1273 (-4.7A)
None
None
CDP  A1269 ( 4.1A)
 1.24A 3mdtA-2v8pA:
undetectable		 3mdtA-2v8pA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 8 TYR A  63
VAL A  62
ILE A  83
GLU A  70
 None
 1.03A 4a97D-2v8pA:
undetectable		 4a97D-2v8pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 7 TYR A  63
VAL A  62
ILE A  83
GLU A  70
 None
 1.04A 4a97H-2v8pA:
undetectable		 4a97H-2v8pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 12 VAL A 163
LEU A 162
GLY A 247
ALA A 248
LEU A 252
 None
 1.01A 4coxC-2v8pA:
undetectable		 4coxC-2v8pA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 12 VAL A 163
LEU A 162
GLY A 247
ALA A 248
LEU A 252
 None
 1.04A 4rrwD-2v8pA:
undetectable		 4rrwD-2v8pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 12 VAL A 163
LEU A 162
GLY A 247
ALA A 248
LEU A 252
 None
 1.04A 4rrzD-2v8pA:
undetectable		 4rrzD-2v8pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 12 ALA A 212
GLY A 237
GLY A 239
GLY A  90
LEU A  14
 None
None
None
ADP  A1270 (-3.2A)
None
 1.19A 5c0oE-2v8pA:
undetectable		 5c0oE-2v8pA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_SAMB503_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 12 GLY A 237
ASN A 206
SER A 240
THR A 171
TYR A 175
 None
None
None
CDP  A1269 ( 4.1A)
CDP  A1269 (-3.6A)
 1.48A 5yf0B-2v8pA:
undetectable		 5yf0B-2v8pA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		4 / 8 LEU A 123
LEU A 120
LEU A  61
GLY A  96
 None
None
ADP  A1270 (-3.9A)
ADP  A1270 (-3.4A)
 0.93A 6ce2A-2v8pA:
undetectable		 6ce2A-2v8pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Aquifex
aeolicus) 		5 / 12 LEU A  30
ILE A 141
GLY A 142
ILE A 196
ILE A 193
 None
 0.97A 6emuA-2v8pA:
undetectable		 6emuA-2v8pA:
21.75