SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2v8s VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1B
(Homo
sapiens) 		4 / 8 PHE V  11
PHE V  73
MET V  77
SER V  79
 None
 0.95A 1wrlC-2v8sV:
undetectable
1wrlD-2v8sV:
undetectable		 1wrlC-2v8sV:
22.02
1wrlD-2v8sV:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2v8s VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1B
(Homo
sapiens) 		3 / 3 HIS V  15
MET V  62
MET V  77
 None
 1.38A 2vj1A-2v8sV:
undetectable		 2vj1A-2v8sV:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v8s VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1B
(Homo
sapiens) 		4 / 5 MET V  62
LEU V  81
ARG V  19
SER V   4
 None
None
None
GOL  V1095 (-3.5A)
 1.21A 4kmmB-2v8sV:
undetectable		 4kmmB-2v8sV:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2v8s CLATHRIN INTERACTOR
1
(Homo
sapiens) 		4 / 6 LEU E  86
LEU E  89
PHE E  57
HIS E 104
 None
None
None
GOL  E1159 (-4.2A)
 0.78A 5gs4A-2v8sE:
undetectable		 5gs4A-2v8sE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2v8s CLATHRIN INTERACTOR
1
(Homo
sapiens) 		4 / 7 ARG E 102
ILE E 105
LEU E  86
ARG E  96
 None
 1.03A 5vc0A-2v8sE:
undetectable		 5vc0A-2v8sE:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2v8s CLATHRIN INTERACTOR
1
(Homo
sapiens) 		3 / 3 ARG E 102
ARG E 149
ARG E  96
 None
 1.02A 5vcgA-2v8sE:
undetectable		 5vcgA-2v8sE:
14.49