SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		4 / 8 VAL A  64
SER A  58
ASN A  44
ASP A 106
 None
 1.26A 1hwiB-2v91A:
undetectable		 1hwiB-2v91A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		4 / 8 VAL A  64
SER A  58
ASN A  44
ASP A 106
 None
 1.26A 1hwkA-2v91A:
undetectable		 1hwkA-2v91A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		4 / 5 SER A  58
TYR A 319
SER A 267
ASP A 106
 None
 1.46A 1vidA-2v91A:
undetectable		 1vidA-2v91A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		4 / 8 THR A 154
ASN A 259
ALA A 216
ARG A 158
 None
 1.10A 2ij7C-2v91A:
undetectable		 2ij7C-2v91A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		4 / 6 THR A 199
ASP A 166
THR A 169
ASP A 172
 None
 1.30A 2okcB-2v91A:
undetectable		 2okcB-2v91A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		6 / 12 VAL A 248
VAL A 266
SER A 268
GLY A 210
ALA A 224
LEU A 222
 None
None
None
S55  A1334 (-3.5A)
None
None
 1.32A 3hs6A-2v91A:
undetectable		 3hs6A-2v91A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		3 / 3 HIS A 277
SER A 269
GLU A 271
 S55  A1334 (-4.2A)
S55  A1334 ( 3.7A)
None
 0.92A 3s8pA-2v91A:
undetectable		 3s8pA-2v91A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		4 / 5 PHE A  55
PHE A  46
LEU A 331
PRO A 300
 None
 1.29A 4o8zA-2v91A:
undetectable		 4o8zA-2v91A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		5 / 11 TYR A  56
ASP A  49
PHE A  77
VAL A 128
LEU A 111
 None
 1.40A 5huaA-2v91A:
undetectable		 5huaA-2v91A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		4 / 8 TYR A  56
ASP A  49
PHE A  77
VAL A 128
 None
 0.94A 5hw8H-2v91A:
undetectable		 5hw8H-2v91A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2v91 STRICTOSIDINE
SYNTHASE
(Rauvolfia
serpentina) 		3 / 3 TYR A 163
ASP A 193
ASP A 156
 None
 0.73A 5x6yA-2v91A:
undetectable		 5x6yA-2v91A:
17.01