SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 12 SER A 363
LEU A  82
LEU A 286
PHE A  79
ILE A  75
 None
 1.42A 1uobA-2v95A:
undetectable		 1uobA-2v95A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 5 SER A  89
TYR A  81
SER A  44
ASP A 358
 None
 1.30A 1vidA-2v95A:
undetectable		 1vidA-2v95A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 6 MET A 314
LEU A 109
PHE A 113
MET A 101
 None
 1.17A 1x8vA-2v95A:
undetectable		 1x8vA-2v95A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 12 SER A  42
SER A  39
ILE A  38
ASN A 169
ILE A 152
 None
 1.03A 2nnhA-2v95A:
undetectable		 2nnhA-2v95A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 5 LEU A 320
ALA A 318
ILE A 171
SER A  39
 None
 0.88A 2othA-2v95A:
undetectable		 2othA-2v95A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		3 / 3 ASN A   7
ARG A  10
ASP A 256
 None
None
HCY  A1375 (-3.6A)
 1.00A 2qe6B-2v95A:
undetectable		 2qe6B-2v95A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.64A 2vdyA-2v95A:
38.4		 2vdyA-2v95A:
60.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.61A 2vdyB-2v95A:
38.1		 2vdyB-2v95A:
60.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 7 ILE A 152
GLN A 142
ALA A 136
ILE A 128
 None
 0.85A 2xkwA-2v95A:
undetectable		 2xkwA-2v95A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 11 SER A  42
ILE A  38
SER A 364
VAL A 168
LEU A 167
 None
 1.40A 3a9eB-2v95A:
undetectable		 3a9eB-2v95A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 12 PHE A 352
LEU A 222
PHE A 235
LEU A 322
LEU A  37
 None
 1.49A 3adsA-2v95A:
undetectable		 3adsA-2v95A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 8 LEU A 269
LEU A 354
ILE A 346
PHE A 348
 None
 0.95A 3ln1A-2v95A:
undetectable		 3ln1A-2v95A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 7 LEU A 269
LEU A 354
ILE A 346
PHE A 348
 None
 0.93A 3ln1B-2v95A:
undetectable		 3ln1B-2v95A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 6 PHE A  79
ASN A  16
PHE A  19
ALA A  20
 None
 1.16A 3t3sB-2v95A:
undetectable		 3t3sB-2v95A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 11 ALA A  13
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
TRP A 362
 HCY  A1375 (-3.6A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 (-3.8A)
 0.59A 4bb2A-2v95A:
30.2
4bb2B-2v95A:
undetectable		 4bb2A-2v95A:
56.80
4bb2B-2v95A:
5.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 11 ALA A  20
GLN A 224
THR A 232
PHE A 234
ILE A 255
 None
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
 1.40A 4bb2A-2v95A:
30.2
4bb2B-2v95A:
undetectable		 4bb2A-2v95A:
56.80
4bb2B-2v95A:
5.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 ALA A  13
VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 (-3.6A)
HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.68A 4c49A-2v95A:
39.0		 4c49A-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
 0.74A 4c49B-2v95A:
39.0		 4c49B-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.52A 4c49B-2v95A:
39.0		 4c49B-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.65A 4c49C-2v95A:
39.2		 4c49C-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
 0.69A 4c49D-2v95A:
37.5		 4c49D-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.57A 4c49D-2v95A:
37.5		 4c49D-2v95A:
61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		3 / 3 LEU A  37
MET A 276
ASP A 358
 None
 0.76A 4j7xB-2v95A:
undetectable		 4j7xB-2v95A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 9 TYR A 170
PHE A 102
HIS A 143
MET A  49
 None
 1.31A 4jvlA-2v95A:
undetectable		 4jvlA-2v95A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 12 VAL A 144
SER A 157
PHE A 156
ASN A 141
ASP A 160
 None
 1.38A 4pevA-2v95A:
undetectable		 4pevA-2v95A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 12 VAL A 144
SER A 157
PHE A 156
ASN A 141
ASP A 160
 None
 1.38A 4pevB-2v95A:
undetectable		 4pevB-2v95A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		3 / 3 LYS A 359
ARG A  10
HIS A   9
 HCY  A1375 (-4.8A)
None
None
 1.14A 4zbrA-2v95A:
undetectable		 4zbrA-2v95A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 11 ASN A  99
LEU A 167
LEU A  52
GLY A  53
ALA A  48
 None
 1.28A 5fctA-2v95A:
undetectable		 5fctA-2v95A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 5 SER A  89
TYR A  81
SER A  44
ASP A 358
 None
 1.25A 5fhrA-2v95A:
undetectable		 5fhrA-2v95A:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HGC_A_HCYA501_1
(SERPIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 12 PRO A  14
THR A 232
PHE A 234
ILE A 255
PHE A 357
 HCY  A1375 (-3.4A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
 0.54A 5hgcA-2v95A:
22.9		 5hgcA-2v95A:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 4 ASN A 169
LEU A 282
SER A  44
LEU A  23
 None
 1.34A 5kb5A-2v95A:
undetectable		 5kb5A-2v95A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 5 LEU A 103
PHE A 102
LEU A 109
PHE A 113
 None
 1.22A 5x1fC-2v95A:
undetectable
5x1fJ-2v95A:
undetectable		 5x1fC-2v95A:
20.05
5x1fJ-2v95A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 9 SER A 368
ILE A 247
PRO A 238
VAL A 246
ILE A 353
 None
 1.28A 6ef6A-2v95A:
undetectable		 6ef6A-2v95A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		4 / 6 TYR A 192
VAL A 201
VAL A 199
THR A 198
 None
 1.31A 6f32B-2v95A:
undetectable		 6f32B-2v95A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 11 ASN A  99
LEU A 167
LEU A  52
GLY A  53
ALA A  48
 None
 1.30A 6r2eF-2v95A:
undetectable		 6r2eF-2v95A:
23.37