SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 9 GLY A 216
ALA A 120
HIS A 204
ILE A 139
GLY A 181
 None
None
ZN  A1276 (-3.3A)
None
ZN  A1276 ( 4.2A)
 1.20A 1c9sQ-2v9iA:
undetectable
1c9sR-2v9iA:
undetectable		 1c9sQ-2v9iA:
16.41
1c9sR-2v9iA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 8 ALA A 235
GLU A 232
LEU A 147
LEU A 154
 None
 0.97A 1ereE-2v9iA:
undetectable		 1ereE-2v9iA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 8 ALA A 235
GLU A 232
LEU A 147
LEU A 154
 None
 0.98A 1ereF-2v9iA:
undetectable		 1ereF-2v9iA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 8 LEU A 123
ARG A 128
PHE A 215
GLY A 216
 None
 0.94A 1fapB-2v9iA:
undetectable		 1fapB-2v9iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 10 GLY A 181
GLY A 216
ALA A 120
HIS A 204
ILE A 139
 ZN  A1276 ( 4.2A)
None
None
ZN  A1276 (-3.3A)
None
 1.15A 1gtfJ-2v9iA:
undetectable
1gtfK-2v9iA:
undetectable		 1gtfJ-2v9iA:
16.41
1gtfK-2v9iA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 12 THR A  17
ILE A  92
GLY A  91
GLY A  74
ALA A  88
 None
 1.02A 1nv8A-2v9iA:
undetectable		 1nv8A-2v9iA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 12 THR A  17
ILE A  92
GLY A  91
GLY A  74
ALA A  88
 None
 1.02A 1nv8B-2v9iA:
undetectable		 1nv8B-2v9iA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 5 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 1.07A 1rs7A-2v9iA:
undetectable		 1rs7A-2v9iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 12 THR A  17
ILE A  92
GLY A  91
GLY A  74
ALA A  88
 None
 1.04A 1sg9B-2v9iA:
undetectable		 1sg9B-2v9iA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 10 GLY A 216
ALA A 120
HIS A 204
ILE A 139
GLY A 181
 None
None
ZN  A1276 (-3.3A)
None
ZN  A1276 ( 4.2A)
 1.16A 1utdH-2v9iA:
undetectable
1utdI-2v9iA:
undetectable		 1utdH-2v9iA:
16.41
1utdI-2v9iA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 12 THR A  17
ILE A  92
GLY A  91
GLY A  74
ALA A  88
 None
 0.97A 1vq1B-2v9iA:
undetectable		 1vq1B-2v9iA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.91A 1zzqA-2v9iA:
0.0		 1zzqA-2v9iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 5 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.95A 1zzqB-2v9iA:
undetectable		 1zzqB-2v9iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 5 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.92A 1zzuA-2v9iA:
undetectable		 1zzuA-2v9iA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 12 MET A 140
ASP A  26
ASN A  32
GLY A 216
ILE A 228
 None
 1.42A 2dcfA-2v9iA:
undetectable		 2dcfA-2v9iA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 LEU A 165
THR A 162
PHE A 176
LEU A 173
 None
 1.06A 2wm3A-2v9iA:
undetectable		 2wm3A-2v9iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A 120
HIS A 143
HIS A 141
GLY A 189
ILE A 193
 None
ZN  A1275 (-3.2A)
ZN  A1275 (-3.2A)
None
None
 0.96A 2x1lA-2v9iA:
undetectable		 2x1lA-2v9iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 12 ALA A 120
HIS A 143
HIS A 141
GLY A 189
ILE A 193
 None
ZN  A1275 (-3.2A)
ZN  A1275 (-3.2A)
None
None
 0.93A 2x1lB-2v9iA:
undetectable		 2x1lB-2v9iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A 120
HIS A 143
HIS A 141
GLY A 189
ILE A 193
 None
ZN  A1275 (-3.2A)
ZN  A1275 (-3.2A)
None
None
 0.92A 2x1lC-2v9iA:
undetectable		 2x1lC-2v9iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
 None
 1.42A 2y7kA-2v9iA:
undetectable		 2y7kA-2v9iA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 10 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
 None
 1.48A 2y7pA-2v9iA:
undetectable		 2y7pA-2v9iA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 9 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
 None
 1.31A 2y7wA-2v9iA:
undetectable		 2y7wA-2v9iA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 10 THR A 224
GLY A 218
GLY A 216
HIS A 125
ILE A 139
 None
 1.31A 2y7wB-2v9iA:
undetectable		 2y7wB-2v9iA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 8 ALA A 120
HIS A 141
GLY A 194
ILE A 193
 None
ZN  A1275 (-3.2A)
None
None
 0.87A 2zm9A-2v9iA:
undetectable		 2zm9A-2v9iA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 MET A 140
ASP A  26
ASN A  32
GLY A 216
ILE A 228
 None
 1.41A 2zmaA-2v9iA:
0.0		 2zmaA-2v9iA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		3 / 3 CYH A 126
HIS A 125
PHE A 122
 None
 1.20A 3cr4X-2v9iA:
undetectable		 3cr4X-2v9iA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 VAL A 138
LEU A 108
ILE A   4
LEU A  33
 None
 0.89A 3kk6A-2v9iA:
undetectable		 3kk6A-2v9iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 VAL A 138
LEU A 108
ILE A   4
LEU A  33
 None
 0.90A 3kk6B-2v9iA:
undetectable		 3kk6B-2v9iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 PHE A  70
PHE A 122
HIS A 121
VAL A  72
 None
 1.25A 3lb3B-2v9iA:
undetectable		 3lb3B-2v9iA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 1.14A 3n65A-2v9iA:
0.0		 3n65A-2v9iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 1.13A 3n66A-2v9iA:
0.0		 3n66A-2v9iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 10 MET A 140
ASP A  26
ASN A  32
GLY A 216
ILE A 228
 None
 1.42A 3vwpA-2v9iA:
0.0		 3vwpA-2v9iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 12 MET A 140
ASP A  26
ASN A  32
GLY A 216
ILE A 228
 None
 1.43A 3vwqA-2v9iA:
undetectable		 3vwqA-2v9iA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 MET A 140
ASP A  26
ASN A  32
GLY A 216
ILE A 228
 None
 1.40A 3vwrA-2v9iA:
0.0		 3vwrA-2v9iA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 GLU A 167
GLY A 168
LEU A 256
GLU A 171
 None
 0.90A 3w9tB-2v9iA:
undetectable		 3w9tB-2v9iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 GLU A 167
GLY A 168
LEU A 256
GLU A 171
 None
 0.90A 3w9tE-2v9iA:
undetectable		 3w9tE-2v9iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 GLU A 167
GLY A 168
LEU A 256
GLU A 171
 None
 0.91A 3w9tF-2v9iA:
undetectable		 3w9tF-2v9iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 5 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.96A 4d33A-2v9iA:
undetectable		 4d33A-2v9iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 5 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.96A 4d33B-2v9iA:
undetectable		 4d33B-2v9iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 4 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.93A 4d39A-2v9iA:
0.0		 4d39A-2v9iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 0.96A 4d39B-2v9iA:
undetectable		 4d39B-2v9iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 6 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 1.07A 4kcnA-2v9iA:
undetectable		 4kcnA-2v9iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A  88
THR A  17
MET A  13
PHE A   9
THR A 109
 None
 1.30A 4kyaA-2v9iA:
undetectable		 4kyaA-2v9iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A  88
THR A  17
MET A  13
PHE A   9
THR A 109
 None
 1.29A 4kyaE-2v9iA:
undetectable		 4kyaE-2v9iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A  88
THR A  17
MET A  13
PHE A   9
THR A 109
 None
 1.30A 4kyaG-2v9iA:
undetectable		 4kyaG-2v9iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 9 ALA A  20
THR A  17
ALA A  16
GLY A  30
GLY A  31
 None
None
None
ZN  A1275 ( 4.9A)
ZN  A1275 ( 4.6A)
 1.15A 4qwuK-2v9iA:
undetectable
4qwuL-2v9iA:
undetectable		 4qwuK-2v9iA:
20.57
4qwuL-2v9iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		5 / 9 ALA A  20
THR A  17
ALA A  16
GLY A  30
GLY A  31
 None
None
None
ZN  A1275 ( 4.9A)
ZN  A1275 ( 4.6A)
 1.17A 4qwuY-2v9iA:
undetectable
4qwuZ-2v9iA:
undetectable		 4qwuY-2v9iA:
20.57
4qwuZ-2v9iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		3 / 3 SER A 243
GLU A 232
GLU A  27
 None
 0.75A 4ymgB-2v9iA:
undetectable		 4ymgB-2v9iA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE
(Escherichia
coli) 		4 / 5 GLY A 194
TRP A 209
VAL A 207
SER A 124
 None
 1.12A 5vunA-2v9iA:
undetectable		 5vunA-2v9iA:
20.10