SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 6 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.83A 1etb2-2v9tB:
undetectable		 1etb2-2v9tB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 8 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.96A 1sn5C-2v9tB:
undetectable		 1sn5C-2v9tB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 11 LEU B 374
ASN B 406
ILE B 384
LEU B 363
PHE B 392
 None
 1.33A 1tw4A-2v9tB:
undetectable		 1tw4A-2v9tB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 7 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.87A 1tyrB-2v9tB:
undetectable		 1tyrB-2v9tB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens;
Homo
sapiens) 		4 / 5 SER A 117
LEU A 122
LEU A 127
LEU B 400
 None
 1.13A 1yajD-2v9tA:
undetectable		 1yajD-2v9tA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 4 LEU B 291
PRO B 295
LEU B 307
ARG B 287
 None
 1.24A 2hrcA-2v9tB:
undetectable		 2hrcA-2v9tB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 12 LEU B 387
LEU B 367
LEU B 353
LEU B 398
THR B 415
 None
 1.10A 2oaxA-2v9tB:
undetectable		 2oaxA-2v9tB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 12 LEU B 326
LEU B 350
LEU B 371
ILE B 305
LEU B 363
 None
 1.01A 2pnjA-2v9tB:
undetectable		 2pnjA-2v9tB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 12 LEU B 350
LEU B 374
LEU B 395
ILE B 329
LEU B 387
 None
 1.04A 2pnjA-2v9tB:
undetectable		 2pnjA-2v9tB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		3 / 3 ILE B 329
ILE B 315
LEU B 398
 None
 0.54A 2prgA-2v9tB:
undetectable		 2prgA-2v9tB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 7 THR B 415
TRP B 440
MET B 425
LEU B 427
 None
 1.43A 2rezA-2v9tB:
0.0		 2rezA-2v9tB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 8 ILE B 384
LEU B 355
LEU B 353
PHE B 392
 None
 0.87A 2vctA-2v9tB:
undetectable		 2vctA-2v9tB:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 6 LEU B 355
GLY B 357
LEU B 353
SER B 352
 None
 0.77A 3aiaA-2v9tB:
undetectable		 3aiaA-2v9tB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 4 LEU B 291
PRO B 295
LEU B 307
ARG B 287
 None
 1.32A 3hcoB-2v9tB:
undetectable		 3hcoB-2v9tB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 2v9t ROUNDABOUT HOMOLOG 1
(Homo
sapiens) 		5 / 9 THR A 110
THR A  86
LEU A 121
LEU A 122
GLY A 125
 None
 1.48A 4c9kA-2v9tA:
undetectable		 4c9kA-2v9tA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 7 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.97A 4d7bA-2v9tB:
undetectable		 4d7bA-2v9tB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 8 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.96A 4iizB-2v9tB:
undetectable		 4iizB-2v9tB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 8 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.95A 4ik6B-2v9tB:
undetectable		 4ik6B-2v9tB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 8 LEU B 326
LEU B 350
LEU B 371
ILE B 305
 None
 0.87A 4klaA-2v9tB:
undetectable		 4klaA-2v9tB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2v9t ROUNDABOUT HOMOLOG 1
(Homo
sapiens) 		4 / 5 PRO A  84
GLY A  82
ASP A  76
ASP A 141
 None
 1.07A 4n48B-2v9tA:
undetectable		 4n48B-2v9tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 6 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.89A 4pwjA-2v9tB:
undetectable		 4pwjA-2v9tB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 7 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.84A 4pwjB-2v9tB:
undetectable		 4pwjB-2v9tB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 5 ALA A 161
TYR A 145
HIS B 426
PHE A 129
 None
 1.04A 4ze2A-2v9tA:
undetectable		 4ze2A-2v9tA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		6 / 11 LEU B 441
LEU B 379
LEU B 398
LEU B 419
ILE B 422
LEU B 377
 None
 1.23A 4zowA-2v9tB:
undetectable		 4zowA-2v9tB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 7 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.83A 5bojB-2v9tB:
undetectable		 5bojB-2v9tB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		5 / 12 MET B 425
THR B 424
GLY B 454
ILE B 468
ALA B 428
 None
 1.19A 5kvaB-2v9tB:
undetectable		 5kvaB-2v9tB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ILE A  70
ARG B 287
LYS B 289
SER B 280
 None
 0.99A 6c06C-2v9tA:
undetectable		 6c06C-2v9tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens;
Homo
sapiens) 		5 / 12 SER A  75
ASN B 334
ASN B 358
LEU B 331
GLY B 288
 None
 1.30A 6dwnA-2v9tA:
undetectable		 6dwnA-2v9tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens) 		4 / 6 PHE B 344
LEU B 367
ALA B 343
ASN B 334
 None
 0.99A 6f88A-2v9tB:
undetectable		 6f88A-2v9tB:
15.91