SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 11 LEU A 702
LEU A 781
ILE A 681
GLY A 685
LEU A 687
 None
 1.27A 1g50C-2v9yA:
undetectable		 1g50C-2v9yA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		3 / 3 LEU A 694
PRO A 695
LEU A 698
 None
 0.47A 1hrkA-2v9yA:
undetectable		 1hrkA-2v9yA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 9 GLY A 513
GLY A 497
LEU A 500
SER A 621
GLY A 495
 None
SO4  A1793 ( 3.8A)
None
None
None
 1.25A 1jhyA-2v9yA:
undetectable		 1jhyA-2v9yA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 9 TYR A 662
HIS A 680
GLY A 736
PHE A 624
ILE A 661
 None
 1.44A 1oltA-2v9yA:
0.0		 1oltA-2v9yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		3 / 3 VAL A 517
ALA A 518
HIS A 620
 None
 0.54A 1q23C-2v9yA:
undetectable		 1q23C-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		3 / 3 VAL A 517
ALA A 518
HIS A 620
 None
 0.53A 1q23H-2v9yA:
undetectable		 1q23H-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		3 / 3 VAL A 517
ALA A 518
HIS A 620
 None
 0.54A 1q23G-2v9yA:
undetectable		 1q23G-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		3 / 3 VAL A 517
ALA A 518
HIS A 620
 None
 0.64A 1q23L-2v9yA:
undetectable		 1q23L-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		3 / 3 VAL A 517
ALA A 518
HIS A 620
 None
 0.52A 1q23J-2v9yA:
undetectable		 1q23J-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 LEU A 666
GLY A 613
VAL A 611
ALA A 615
LEU A 686
 None
 1.09A 3dh0A-2v9yA:
undetectable		 3dh0A-2v9yA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 LEU A 666
GLY A 613
VAL A 611
ALA A 615
LEU A 686
 None
 1.13A 3dh0B-2v9yA:
undetectable		 3dh0B-2v9yA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		4 / 7 ILE A 681
GLY A 736
SER A 616
PHE A 713
 None
 0.88A 3v7pA-2v9yA:
undetectable		 3v7pA-2v9yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 9 GLY A 513
GLY A 497
LEU A 500
SER A 621
GLY A 495
 None
SO4  A1793 ( 3.8A)
None
None
None
 1.25A 4kqiA-2v9yA:
undetectable		 4kqiA-2v9yA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 ILE A 690
LEU A 702
GLY A 736
SER A 616
ILE A 681
 None
 1.20A 4o1eA-2v9yA:
undetectable		 4o1eA-2v9yA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		4 / 8 LEU A 716
GLY A 618
THR A 657
LEU A 654
 None
 0.79A 5eseA-2v9yA:
undetectable		 5eseA-2v9yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 ASP A 478
ALA A 482
PRO A 487
GLN A 527
GLY A 591
 None
 1.03A 5hfjF-2v9yA:
undetectable		 5hfjF-2v9yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 ASP A 478
ALA A 482
PRO A 487
GLN A 527
GLY A 591
 None
 0.94A 5hfjH-2v9yA:
undetectable		 5hfjH-2v9yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 PHE A 713
LEU A 739
ARG A 660
GLY A 736
ILE A 681
 None
 1.16A 5ifuA-2v9yA:
undetectable		 5ifuA-2v9yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		4 / 8 GLN A 718
GLY A 720
GLN A 637
TRP A 715
 None
 0.93A 5vlmH-2v9yA:
undetectable		 5vlmH-2v9yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 ALA A 558
ASP A 536
GLY A 587
ALA A 586
LEU A 500
 None
 1.03A 5xxiA-2v9yA:
undetectable		 5xxiA-2v9yA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Homo
sapiens) 		5 / 12 GLY A 618
THR A 682
GLY A 683
GLY A 684
MET A 519
 None
 1.04A 6brdB-2v9yA:
undetectable		 6brdB-2v9yA:
14.37