SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2va0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2va0 ABFS
ARABINOFURANOSIDASE
TWO COMPONENT SYSTEM
SENSOR PROTEIN
(Cellvibrio
japonicus) 		5 / 12 THR A 133
LEU A 134
ILE A 132
ASN A  61
LEU A  95
 CL  A1149 (-4.9A)
None
CL  A1149 ( 4.6A)
None
None
 1.26A 1wsvB-2va0A:
undetectable		 1wsvB-2va0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2va0 ABFS
ARABINOFURANOSIDASE
TWO COMPONENT SYSTEM
SENSOR PROTEIN
(Cellvibrio
japonicus) 		4 / 8 LEU A  74
VAL A 142
TYR A  86
LEU A  82
 None
 1.01A 3v81A-2va0A:
undetectable		 3v81A-2va0A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2va0 ABFS
ARABINOFURANOSIDASE
TWO COMPONENT SYSTEM
SENSOR PROTEIN
(Cellvibrio
japonicus) 		5 / 11 LEU A  95
LEU A 134
ASN A 138
VAL A 142
ILE A 132
 None
None
None
None
CL  A1149 ( 4.6A)
 1.14A 4x20D-2va0A:
undetectable		 4x20D-2va0A:
14.25