SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2va1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 12 THR A 182
ALA A 186
LEU A 187
MET A 194
ILE A 154
 None
 0.94A 1errA-2va1A:
undetectable		 1errA-2va1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 10 THR A  95
VAL A 124
ALA A  87
ALA A  32
ILE A  28
 None
 1.11A 1likA-2va1A:
undetectable		 1likA-2va1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 9 ASP A  70
GLY A 132
SER A 140
ASP A 195
THR A 197
 None
 1.38A 1m4gB-2va1A:
0.0		 1m4gB-2va1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 11 SER A  39
VAL A  44
ILE A   8
LEU A  88
LEU A  84
 None
 1.22A 2a15A-2va1A:
undetectable		 2a15A-2va1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		4 / 8 LEU A  84
ILE A  35
ILE A  10
ILE A   8
 None
 0.75A 2bu8A-2va1A:
undetectable		 2bu8A-2va1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		4 / 4 THR A 197
THR A 137
ASP A  70
ASP A  65
 None
 1.36A 2f8lA-2va1A:
undetectable		 2f8lA-2va1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 11 GLY A  56
MET A  72
GLY A  73
THR A 137
THR A 138
 None
None
None
None
PO4  A1236 (-3.2A)
 1.49A 3ag1G-2va1A:
0.0
3ag1N-2va1A:
0.3
3ag1O-2va1A:
0.0		 3ag1G-2va1A:
14.29
3ag1N-2va1A:
17.28
3ag1O-2va1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 12 LEU A  15
GLY A  49
GLY A  12
ALA A  76
THR A  77
 None
PO4  A1236 (-3.3A)
PO4  A1236 (-3.6A)
None
None
 1.11A 3dh0B-2va1A:
undetectable		 3dh0B-2va1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 9 ILE A  38
ILE A 220
VAL A  44
ILE A  10
ILE A  46
 None
 1.21A 3p4wB-2va1A:
undetectable		 3p4wB-2va1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 10 ILE A  38
ILE A 220
VAL A  44
ILE A  10
ILE A  46
 None
 1.22A 3p4wD-2va1A:
undetectable		 3p4wD-2va1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 10 ILE A  38
ILE A 220
VAL A  44
ILE A  10
ILE A  46
 None
 1.21A 3p4wE-2va1A:
undetectable		 3p4wE-2va1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		4 / 7 GLY A  50
ASN A  80
GLY A 130
THR A 131
 PO4  A1236 (-4.0A)
None
None
None
 0.74A 3tajA-2va1A:
undetectable		 3tajA-2va1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 9 ILE A  10
LEU A  88
SER A  39
ILE A  38
ILE A   8
 None
 1.05A 3tq8A-2va1A:
undetectable		 3tq8A-2va1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		4 / 7 LEU A  31
GLU A  85
ASN A  52
ILE A  22
 None
 0.96A 5jh7C-2va1A:
undetectable		 5jh7C-2va1A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		4 / 8 ILE A   6
ALA A 146
LEU A 209
ILE A   8
 None
 0.74A 5uihA-2va1A:
undetectable		 5uihA-2va1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_G_CHDG101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 10 GLY A  56
MET A  72
GLY A  73
THR A 137
THR A 138
 None
None
None
None
PO4  A1236 (-3.2A)
 1.49A 5z84G-2va1A:
0.0
5z84N-2va1A:
0.0
5z84O-2va1A:
0.0		 5z84G-2va1A:
14.29
5z84N-2va1A:
17.28
5z84O-2va1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 9 GLY A  56
MET A  72
GLY A  73
THR A 137
THR A 138
 None
None
None
None
PO4  A1236 (-3.2A)
 1.43A 6nknG-2va1A:
0.0
6nknN-2va1A:
0.0
6nknO-2va1A:
0.0		 6nknG-2va1A:
14.29
6nknN-2va1A:
17.28
6nknO-2va1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 10 GLY A  56
MET A  72
GLY A  73
THR A 137
THR A 138
 None
None
None
None
PO4  A1236 (-3.2A)
 1.44A 6nmfG-2va1A:
0.0
6nmfN-2va1A:
0.2
6nmfO-2va1A:
0.0		 6nmfG-2va1A:
14.29
6nmfN-2va1A:
17.28
6nmfO-2va1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2va1 URIDYLATE KINASE
(Ureaplasma
parvum) 		5 / 10 GLY A  56
MET A  72
GLY A  73
THR A 137
THR A 138
 None
None
None
None
PO4  A1236 (-3.2A)
 1.40A 6nmpG-2va1A:
0.0
6nmpN-2va1A:
0.1
6nmpO-2va1A:
0.0		 6nmpG-2va1A:
14.29
6nmpN-2va1A:
17.28
6nmpO-2va1A:
17.84