SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2va8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A  37
LEU A  36
LEU A 174
GLY A  59
 None
 0.95A 1a4lC-2va8A:
undetectable		 1a4lC-2va8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.92A 1d4yA-2va8A:
undetectable		 1d4yA-2va8A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 8 MET A 581
GLU A 609
ASP A 612
ARG A 642
 None
 1.25A 1dtlA-2va8A:
undetectable		 1dtlA-2va8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  44
GLU A 191
LEU A 174
LEU A 171
LEU A 144
 None
 1.37A 1ie4A-2va8A:
undetectable
1ie4C-2va8A:
undetectable		 1ie4A-2va8A:
10.77
1ie4C-2va8A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A 171
LEU A 144
LEU A  44
GLU A 191
LEU A 174
 None
 1.32A 1ie4A-2va8A:
undetectable
1ie4C-2va8A:
undetectable		 1ie4A-2va8A:
10.77
1ie4C-2va8A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.14A 1kifA-2va8A:
undetectable		 1kifA-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.14A 1kifB-2va8A:
undetectable		 1kifB-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.14A 1kifC-2va8A:
undetectable		 1kifC-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.13A 1kifD-2va8A:
undetectable		 1kifD-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.14A 1kifE-2va8A:
undetectable		 1kifE-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.14A 1kifF-2va8A:
undetectable		 1kifF-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.13A 1kifG-2va8A:
undetectable		 1kifG-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.13A 1kifH-2va8A:
undetectable		 1kifH-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.94A 1t3rA-2va8A:
undetectable		 1t3rA-2va8A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.07A 1ve9A-2va8A:
undetectable		 1ve9A-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 4 LEU A 263
SER A 260
TYR A 310
LEU A 303
 None
 1.32A 1xz3A-2va8A:
undetectable		 1xz3A-2va8A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 4 LEU A 300
SER A 601
LEU A 322
LEU A 286
 None
 1.03A 1yajA-2va8A:
undetectable		 1yajA-2va8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 300
SER A 601
LEU A 322
LEU A 286
 None
 1.07A 1yajD-2va8A:
2.2		 1yajD-2va8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.98A 2aquA-2va8A:
undetectable		 2aquA-2va8A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.06A 2du8G-2va8A:
undetectable		 2du8G-2va8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.07A 2du8J-2va8A:
undetectable		 2du8J-2va8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 5 ASP A 126
SER A 161
LEU A 434
GLY A 435
 None
 1.04A 2j2pA-2va8A:
undetectable
2j2pB-2va8A:
undetectable		 2j2pA-2va8A:
14.86
2j2pB-2va8A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A  61
ILE A 117
LEU A  64
ASN A  67
VAL A 139
 None
 1.16A 2nnhB-2va8A:
undetectable		 2nnhB-2va8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.80A 2o4pA-2va8A:
undetectable		 2o4pA-2va8A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 ILE A  61
ILE A  15
LEU A 174
 None
 0.54A 2prgA-2va8A:
undetectable		 2prgA-2va8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.96A 2qhcA-2va8A:
undetectable		 2qhcA-2va8A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A 144
TRP A 135
THR A 120
HIS A 131
 None
 1.20A 3asoC-2va8A:
undetectable
3asoN-2va8A:
undetectable
3asoP-2va8A:
undetectable		 3asoC-2va8A:
17.32
3asoN-2va8A:
21.94
3asoP-2va8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 8 ALA A 194
THR A 177
ILE A 178
THR A  45
 None
 0.97A 3bpxA-2va8A:
8.2
3bpxB-2va8A:
6.7		 3bpxA-2va8A:
12.13
3bpxB-2va8A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.80A 3bvbB-2va8A:
undetectable		 3bvbB-2va8A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.86A 3d1xA-2va8A:
undetectable		 3d1xA-2va8A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  44
ALA A  31
LYS A  34
ASN A  40
VAL A 143
 None
 1.23A 3e22B-2va8A:
undetectable		 3e22B-2va8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  44
ALA A  31
LYS A  34
ASN A  40
VAL A 143
 None
 1.24A 3e22D-2va8A:
undetectable		 3e22D-2va8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.97A 3ekyA-2va8A:
undetectable		 3ekyA-2va8A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 8 ALA A 233
ASP A 232
GLY A 355
ILE A 354
 None
 0.81A 3el9A-2va8A:
undetectable		 3el9A-2va8A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 7 VAL A 462
LYS A 459
TYR A 453
GLU A 445
 None
 1.24A 3hs4A-2va8A:
undetectable		 3hs4A-2va8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.91A 3lzvA-2va8A:
undetectable		 3lzvA-2va8A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 286
LEU A 300
SER A 316
SER A 601
GLN A 285
 None
 1.25A 3m7rA-2va8A:
undetectable		 3m7rA-2va8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 9 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.92A 3ndwB-2va8A:
undetectable		 3ndwB-2va8A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.90A 3ndxB-2va8A:
undetectable		 3ndxB-2va8A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.91A 3oy4B-2va8A:
undetectable		 3oy4B-2va8A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 6 VAL A 218
TYR A 237
GLU A 393
ILE A 203
 None
 0.76A 3q5sA-2va8A:
0.6		 3q5sA-2va8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.88A 3tl9A-2va8A:
undetectable		 3tl9A-2va8A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A   6
ILE A   3
LEU A  54
GLU A  57
ARG A  19
 None
 1.37A 4b9zA-2va8A:
undetectable		 4b9zA-2va8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.87A 4dqfB-2va8A:
undetectable		 4dqfB-2va8A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A 164
ARG A 168
ARG A 165
PRO A 502
 None
 1.27A 4f4dB-2va8A:
4.6		 4f4dB-2va8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 521
LEU A 524
LEU A 527
ALA A 528
MET A 607
 None
 1.31A 4fn9B-2va8A:
undetectable		 4fn9B-2va8A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 612
ARG A 642
ASP A 104
 None
 0.79A 4fzvA-2va8A:
undetectable		 4fzvA-2va8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A   8
PRO A   9
ARG A  19
 None
 0.62A 4klrB-2va8A:
4.2		 4klrB-2va8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 9 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.87A 4q1wA-2va8A:
undetectable		 4q1wA-2va8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.90A 4q1xA-2va8A:
undetectable		 4q1xA-2va8A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.90A 4q1yA-2va8A:
undetectable		 4q1yA-2va8A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.86A 4qgiA-2va8A:
undetectable		 4qgiA-2va8A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 11 GLU A 298
LEU A 300
LEU A 319
ARG A 605
LEU A 315
 None
 1.13A 4wg0G-2va8A:
undetectable
4wg0H-2va8A:
undetectable
4wg0I-2va8A:
undetectable		 4wg0G-2va8A:
2.20
4wg0H-2va8A:
2.20
4wg0I-2va8A:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 621
VAL A 495
ILE A 500
LEU A 526
LEU A 527
 None
 1.28A 4yvpB-2va8A:
undetectable		 4yvpB-2va8A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 TYR A 141
PHE A  88
ILE A 117
LEU A  36
THR A  45
 None
 1.19A 4zdyA-2va8A:
2.8		 4zdyA-2va8A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		4 / 8 TRP A 135
THR A 120
HIS A 131
LEU A 144
 None
 1.14A 5b1bA-2va8A:
3.1
5b1bC-2va8A:
undetectable
5b1bP-2va8A:
undetectable		 5b1bA-2va8A:
21.94
5b1bC-2va8A:
17.32
5b1bP-2va8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 532
ARG A  78
ARG A 155
 None
SO4  A1706 (-3.6A)
SO4  A1706 (-2.9A)
 0.78A 5eajB-2va8A:
undetectable		 5eajB-2va8A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A  63
LEU A 172
SER A  62
GLU A  38
GLY A  35
 None
 1.12A 5o4yD-2va8A:
undetectable
5o4yE-2va8A:
undetectable		 5o4yD-2va8A:
4.52
5o4yE-2va8A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 377
LYS A 410
SER A 414
 None
 1.43A 5odiA-2va8A:
undetectable		 5odiA-2va8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 HIS A 476
GLU A 475
TRP A 472
 None
 0.95A 5odiD-2va8A:
undetectable		 5odiD-2va8A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 HIS A 476
GLU A 475
TRP A 472
 None
 0.99A 5odqD-2va8A:
undetectable		 5odqD-2va8A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		3 / 3 HIS A 476
GLU A 475
TRP A 472
 None
 0.91A 5odrD-2va8A:
undetectable		 5odrD-2va8A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 ARG A  78
SER A 617
LEU A 614
ILE A 500
ARG A 130
 SO4  A1706 (-3.6A)
None
None
None
None
 1.24A 5uahC-2va8A:
undetectable		 5uahC-2va8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A 388
ALA A 262
ALA A 266
LEU A 274
LEU A 242
 None
 0.89A 6aybA-2va8A:
undetectable		 6aybA-2va8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 233
ASP A 232
GLY A 355
ILE A 354
VAL A 404
 None
 0.83A 6dilA-2va8A:
undetectable		 6dilA-2va8A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2va8 SKI2-TYPE HELICASE
(Sulfolobus
solfataricus) 		5 / 12 TYR A 141
PHE A  88
ILE A 117
LEU A  36
THR A  45
 None
 1.18A 6e8qA-2va8A:
0.9		 6e8qA-2va8A:
6.43